Open Access Medical Books



Edited by Bassam H. Mahboub and Mayank G. Vats .

500 pages . 
Open Access .

One famous saying by Robert Louis Stevenson “It is not a hard thing to know what to write; the hard thing is to know what to leave out" holds very true for us while writing the preface of this book.
Tuberculosis (TB) is as old as mankind and continues to haunt the mankind despite several spectacular advances in the diagnosis and management of TB. TB is the commonest single infectious cause of death and accountable for over 25% of avoidable deaths worldwide but can still be labeled as “Captain of all these men of death”.

In the initial sections of the book chapters covering the basic pathophysiology and the important factors contributing to the same viz. epidemiology of TB, iron metabolism, unusual properties of M. Tuberculosis, lipid inclusion, role of small regulatory RNA and adaptation to survival in human host, which makes it “tough bug” to treat, has been included in details.
Our understanding of the host pathogen interaction at the molecular level, especially immunopathogenesis of TB has improved enormously and has been extensively covered in the book. Chapters have been included to cover several new drug and potential vaccines for TB.
New development such as the interferon-gamma release assays [IGRAs] for latent TB infection, use of liquid culture and molecular method of diagnosis are ushering in a new era in TB diagnostics. Comprehensive knowledge of latest modes of diagnosis has been also incorporated in the book. Furthermore, issues concerning quality assurance in antituberculosis drug susceptibility testing are getting established.
Data are rapidly accumulating from all over the world regarding the efficacy of standardized treatment regimens for drug-sensitive, drug-resistant TB and latent TB infection.
While we are facing the menace of multi drug-resistant TB [MDR-TB], extensively drug-resistant tuberculosis [XDR¬ TB] has emerged threatening to undermine global efforts at TB control. Hence we have included chapters to cover all aspects of the diagnosis and management of MDR TB. This book will cover all these developments in great detail.
With the widespread availability of internet globally various standard web resources available on TB have also been included so that the readers may get the comprehensive and updated guidelines from these resources. The changing clinical presentation of TB, advances in laboratory, imaging diagnostic modalities, therapeutic measures and emergence of MDR TB all suggest a pressing need to have a updated book on TB. Furthermore, while all physicians encounter the TB disease in their clinical practice, there have been a lot of controversies and misconceptions over various issues for the diagnosis and management of TB.
Paucity of a well referenced, updated, standard book of TB has prompted us to undertake this venture sharing the clinical experience of global experts of TB.

Our book contains chapters on epidemiology, immune-pathology, diagnosis, treatment and latest advances for TB, highlighting the global perspective of tuberculosis. World-wide resurgence of MDR TB indicates that the battle against this foe of mankind will continue in the coming years. TB still remains to be a research priority of paramount importance from medical, social and financial aspects and we have attempted to highlight all the aspects for the treatment of TB.
We believe that this book will serve as a practical guide for the diagnosis and management of TB for practicing physicians (especially pulmonologists and internists) and all those who are involved in the management of TB.
This book has several contributors, all of them leading authorities from various parts of the world. All the chapters have been thoroughly re-written and updated with preservation of the views of the contributors in a uniform format. This effort would not have been possible without the kind cooperation of our contributors who patiently went through revisions and updating of their chapters. We convey our heartfelt thanks to all contributors and to InTech Publisher, Croatia for their encouragement and excellent technical assistance as and when required.
Lastly we would like to thank the almighty god, our parents, wives and children, without their untiring support and encouragement this book would not have seen the light of the day.

Dr. Bassam H. Mahboub
Director, Department of Pulmonary Medicine and Allergy,
Rashid Hospital & Dubai Hospital, Dubai;
Assistant Professor, Dept of Medicine & Respiratory Disease & Allergy,
University of Sharjah, UAE

Dr. Mayank G. Vats
Senior Specialist, Pulmonologist,
Intensivist & Sleep Physician,
Rashid Hospital, Dubai Health Authority,
Dubai, UAE



Section 1 of the textbook : Pathophysiology and Immunogenesis of Tuberculosis .

 1 Mycobacterium tuberculosis Adaptation to Survival in a Human Host 3 Beatrice Saviola

 2 The Immune Response to Mycobacterium tuberculosis Infection in Humans 19 Zeev Theodor Handzel

 3 Lipid Inclusions in Mycobacterial Infections 31 Matthias Stehr, Ayssar A. Elamin and Mahavir Singh

 4 The Role of Antibodies in the Defense Against Tuberculosis 57 Armando Acosta, Yamile Lopez, Norazmi Mohd Nor, Rogelio Hernández Pando, Nadine Alvarez, Maria Elena Sarmiento and Aharona Glatman-Freedman

 5 Influence of the Interferon–Gamma (IFN–γ) and Tumor Necrosis Factor Alpha (TNF–α) Gene Polymorphisms in TB Occurrence and Clinical Spectrum 79 Márcia Quinhones Pires Lopes, Raquel Lima de Figueiredo Teixeira, Antonio Basilio de Miranda, Rafael Santos Pinto, Lizânia Borges Spinassé, Fernanda Carvalho Queiroz Mello, José Roberto Lapa e Silva, Philip Noel Suffys and Adalberto Rezende Santos

 6 Tuberculosis Pharmacogenetics: State of The Art 105 Raquel Lima de Figueiredo Teixeira, Márcia Quinhones Pires Lopes, Philip Noel Suffys and Adalberto Rezende Santos

 7 Pathophysiology of Tuberculosis 127 Ruiru Shi and Isamu Sugawara

Section 2 of the textbook : Diagnosis and Management of Tuberculosis .

 8 Laboratory Diagnosis of Tuberculosis - Latest Diagnostic Tools 143 Gunes Senol

 9 Diagnostic Evaluation of Tuberculosis 153 Mochammad Hatta and A. R. Sultan

 10 First– and Second–Line Drugs and Drug Resistance 163 Hum Nath Jnawali and Sungweon Ryoo

Section 3 of the textbook : Multi-Drug Resistant Tuberculosis .

 11 Epidemiology of Multidrug Resistant Tuberculosis (MDR-TB) 183 Dhammika Nayoma Magana-Arachchi

 12 Drug Resistance in M. Tuberculosis 203 Said Hamed Abbadi

 13 Management of Drug-Resistant TB 225 Zakaria Hmama

 14 Drug-Resistant Tuberculosis – Diagnosis, Treatment, Management and Control: The Experience in Thailand 261 Attapon Cheepsattayakorn

Section 4 of the textbook : Extra Pulmonary Tuberculosis .

 15 Tuberculous Pleural Effusion 289 Wolfgang Frank

 16 Neurotuberculosis and HIV Infection 315 Simona Alexandra Iacob and Diana Gabriela Iacob

Section 5 of the textbook : Miscellaneous .

 17 Research and Development of New Drugs Against Tuberculosis 353 Juan D. Guzman, Ximena Montes-Rincón and Wellman Ribón

 18 Web Resources on TB: Information, Research, and Data Analysis 381 Marcos Catanho and Antonio Basílio de Miranda

 19 Peadiatric Tuberculosis: Is the World Doing Enough? 393 Claude Kirimuhuzya

 20 Economic Evaluation of Diagnosis Tuberculosis in Hospital Setting 451 Luciene C. Scherer

 21 Pulmonary Tuberculosis in Latin America: Patchwork Studies Reveal Inequalities in Its Control – The Cases of Chiapas (Mexico), Chine (Ecuador) and Lima (Peru) 465 Héctor Javier Sánchez-Pérez, Olivia Horna–Campos, Natalia Romero-Sandoval, Ezequiel Consiglio and Miguel Martín Mateo

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Published by: Unknown - Saturday, March 23, 2013


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