Open Access Medical Books



Edited by Chao Lin .

212 pages . 

How to successfully circumvent human disease? How to efficaciously treat human disease? How to healthily live to a decent age? These problems have baffled our ancestors for a few centuries. People have attempted to address these puzzled problems since recorded time, but the answers are often disruptive and even unreliable in part due to the modification or alteration of medical principles in every history era. Over the past decades, comprehensive and systematic scientific researches in cell biology and molecular biology have accelerated the evolution of traditional medicine. Scientists are now able to investigate these problems on the basis of molecular levels. Thus, the purpose of this book is to interpret clinical and fundamental medical findings through the lens of 21st-century biomedicine. The contents of this book provide readers with a broad spectrum of basic biomedical understanding dealing with regenerative medicine, gene medicine, and medical devices.
Biomedicine can be divided into four sections: regenerative medicine in Chapter 1 and 2; gene medicine and nanobiomedicine in Chapter 3 to 5; biomedical device performance in Chapter 6 and 7; and public perception of medicine in Chapter 8. Each chapter is intently chosen and written by invited experts or physicians from professional biomedical field, to address hot issues related with contemporary biomedical science. Additionally, the core concepts in each chapter are highlighted and the authors wish readers to grasp them smoothly through readily readable schemes and colourful illustrations. The reference lists also comprise state-of-the-art reviews, relevant research articles, proceedings in frontier conferences, which are
certainly helpful to beginners for further learning.
Chapter 1 provides a complete overview on current methods for the protection of isolated pancreatic islets from host immune response. The authors emphasize an emerging lay-by-lay technique as an innovative route to maintain viability and functions of islet, implying great promise for the treat of diabetes. Next, in-situ forming hydrogels as scaffolds for tissue regeneration are summarized in Chapter 2. Several types of hydrogels that are bioactive and bio-response are outlined in detail and indicated to be highly desirable for clinical practices. Chapter 3 gives an introduction on recent progress in RNA interference (RNAi) for cancer therapy, including mechanisms of gene silencing, cancer-related gene targets for RNAi and RNAi-based clinical trails, although there remain big challenges for clinical RNAi. A latest research arena in the improvement of clinical drug availability is the “nanobiomedicine”, since nanoscale carriers loaded with drugs or genes reveal high possibility for efficient and targeted delivery. Chapter 4 presents the advancement in disulfide-based cationic polymers, in response to intracellular reducing milieu, as nano-carriers for gene transfection. Chapter 5 brings a new outlook on stable magnetic isotopes, which might offer the generation of new pharmaceuticals for biomedical applications. Medical devices are very crucial for diagnosis and therapy of human diseases. Chapter 6 provides recent research progress of fiber-gating sensors for medical diagnosis to facilitate surgery and clinical therapy. The history, working principle and fabrications of optical fiber gratings are introduced thoroughly. In Chapter 7, electron beam melting for processing ferrous metallic powders to fullydense materials is discussed and this technique is valuable in the field of medical implants. At last, a review in Chapter 8 points out the evolution process of public perception on biomedicine in the last decades through survey and statistical data in Spain and other European countries. This chapter is constructive to alarm scientists to take into account public awareness on medicine rather than scientific activity alone.
Thus, I truly believe that Biomedicine is a valuable book that may assist readers to be aware of current advancement in rapidly moving field of biomedicine.

Chao Lin
Tongji University School of Medicine
Tongji University
PR China


Part 1 of the textbook : Regenerative Medicine .

1 Encapsulation and Surface Engineering of Pancreatic Islets: 
Advances and Challenges 3
Veronika Kozlovskaya, Oleksandra Zavgorodnya and Eugenia Kharlampieva

2 In-Situ Forming Biomimetic 
Hydrogels for Tissue Regeneration 35
Rong Jin

Part 2 of the textbook : Gene Medicine and Nanobiomedicine .

3 RNA Interference for Tumor Therapy 61
Wei Xia and Jing Ni

4 Bioreducible Cationic Polymers 
for Gene Transfection 85
Chao Lin and Bo Lou

5 Stable Magnetic Isotopes 
as a New Trend in Biomedicine 105
Vitaly K. Koltover

Part 3 of the textbook : Medical Device Performance .

6 Optical Fiber Gratings in Perspective 
of Their Applications in Biomedicine 125
Vandana Mishra and Nahar Singh

7 Additive Manufacturing 
Solutions for Improved Medical Implants 147
Vojislav Petrovic, Juan Vicente Haro, Jose Ramón Blasco and Luis Portolés

Part 4 of the textbook : Public Perception of Biomedicine .

8 Crossings on Public Perception of Biomedicine: 
Spain and the European Indicators 183
Eulalia Pérez Sedeño and María José Miranda Suárez .

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