Open Access Medical Books



Edited by Madhu Khullar .

246 pages . 
Open Access . 

Hypertension or high blood pressure is one of the most common chronic diseases affecting more than 1 billion people worldwide, and by the year 2025, the global prevalence of hypertension is projected to increase to 29.2% of adult population (Kearney et al., 2005). High blood pressure where the medical cause of the disease is not known is defined as Essential hypertension and is the most common form of hypertension. Essential hypertension is a major risk factor for myocardial infarction, stroke, heart failure and renal failure. The cause of essential hypertension remains largely unknown and is an area of active research. It appears to have multifactorial and complex etiology where genetic and environmental factors play an important role.
The current book addresses some of the research issues related to the pathophysiology, genetics and genomics of hypertension.
This book is divided into two main sections: Pathophysiology, and Genetics and Genomics. In pathophysiology, topics such as pathophysiology of resistant hypertension, target organ damage in hypertension, Baroreflex sensitivity and an interesting hypothesis on music as a therapy for lowering blood pressure are described. Genetics and genomics section provides an overview of different aspects of genetics research in hypertension, including genetic susceptibility markers, mitochondrial mutations and pharmacogenetics of hypertension. A chapter on microarray technology details the technique and identifies expression of altered genes.
Role of TGF-β and other inflammatory genes has been portrayed in another chapter. This book provides comprehensive information on some of the important topics and issues related to pathophysiology of essential hypertension and it is hoped that it will be useful to researchers and clinicians with an interest in Essential hypertension.

Dr Madhu Khullar
Department of Experimental Medicine & Biotechnology
Post Graduate Institute of Medical Education and Research


Part 1 Pathophysiology of Hypertension .

1 Harmful or Helpful Hypertension 
– Pathophysiological Basis 3
M. Kasko, M. Budaj and I. Hulin

2 Target Organ Damage in Essential Hypertension 17
Bogomir Žižek

3 Resistant Hypertension, Elevated 
Aldosterone/Renin Ratio and Reduced RGS2:
A Pathogenetic Link Deserving Further Investigations? 43
Andrea Semplicini, Federica Stella and Giulio Ceolotto

4 Is Low Baroreflex Sensitivity only 
a Consequence of Essential Hypertension
or also a Factor Conditioning Its Development? 67
Natasa Honzikova and Eva Zavodna

5 Does Music Therapy Reduce Blood Pressure 
in Patients with Essential Hypertension in Nigeria? 89
Michael Ezenwa

Part 2 Genetics and Genomics of Hypertension .

6 Recent Trends in Hypertension Genetics Research 101

 Padma Tirunilai and Padma Gunda

7 Candidate Genes in Hypertension 139
 Hayet Soualmia

8 Mitochondrial Mutations in Essential Hypertension 169
 Haiyan Zhu and Shiwen Wang

9 Mitochondrial Mutations in Left Ventricular Hypertrophy 181
Haiyan Zhu and Shiwen Wang

10 Pharmacogenetics of Essential Hypertension 195
Madhu Khullar and Saurabh Sharma

11 Differential Gene Expression 
Profile in Essential Hypertension 211
Ping Yang

12 Potential Roles of TGF-B1 
and EMILIN1 in Essential Hypertension 223
Masanori Shimodaira and Tomohiro Nakayama .

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Published by: younes younes - Monday, March 11, 2013


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