Open Access Medical Books



Edited by Angabin Matin .

160 pages .
Open Access .

In Germ Cell Tumor, leading scientists and physicians from different countries have contributed to review the latest ideas and developments regarding the clinical presentation, current treatment modalities and the biology and genetics of germ cell tumors. Most authors have focused on testicular germ cell tumors which are the most common cancers in young adult males and whose incidence has been increasing in recent years.
The book is divided into two sections. The first section, Clinical Perspectives, discusses observations and current ideas regarding presentation and treatment of germ cell tumors in children and adults. Clinical perspectives includes a comprehensive review by Nick Liu and co-authors regarding the pathogenesis, risk factors, diagnosis and treatment regimens applied to intratubular germ cell neoplasia which are the precursor, pre-invasive lesion for testicular cancers. In Chapter 2, Paul Johnston and Stephen Beck review current management options for the most common type of germ cell tumors of the testes, non-seminomatous germ cell tumors. In Chapter 3, Takamitsu Fujimaki reviews intracranial germ cell tumors, which affect mostly children, and their diagnosis and treatment. Additionally, Chapter 4 reviews current management strategies for all the different histological sub-types of testicular cancers. Nikhil Vasdev and Andrew Thorpe provide a European perspective on treatment of germ cell tumors.
In the second section, Scientific Perspectives, the chapters review current perspectives on experimental systems such as mouse models of testicular germ cell tumors and the genetics and epigenetics of germ cell tumor development in humans and in mice.
Delphine Carouge and Joseph Nadeau provide a thorough review on mouse models of testicular germ cell tumors (Chapter 6). They also compare results obtained from genetic studies of testicular cancer susceptibility in humans to that in mice. Epigenetic dysregulation is implicated in a variety of cancers, including in testicular cancers.
Christopher Payne presents an up to date review on the epigenetic modifications found in normal germ cells, in the pre-invasive precursor cells and in testicular germ cell tumors of young adults (Chapter 7). Yiermi Soini reviews the role of claudins, which are components of tight junctions, in germ cell tumors (Chapter 8).

These chapters will be useful for scientists, physicians and lay readers wishing to review the current status of our knowledge regarding germ cell cancers. We hope that the chapters will serve to inspire further ideas towards increased understanding of development of germ cell cancers and improved treatment and management of this disease. I thank all the authors for their contributions. In addition, I thank Ms. Gorana Scerbe and Dragana Manestar for their invaluable assistance in the preparation and publication of this book.

Angabin Matin
U.T. M.D. Anderson Cancer Center, Houston, Texas



Part 1 Clinical Perspectives .

 1 Intratubular Germ Cell Neoplasms of the Testis and Bilateral Testicular Tumors: Clinical Significance and Management Options 3 Nick W. Liu, Michael C. Risk and Timothy A. Masterson

 2 Management of Nonseminomatous Germ Cell Tumor of the Testis 23 Paul H. Johnston and Stephen D.W. Beck

 3 Diagnostic Imaging of Intracranial Germ Cell Tumors: A Review 47 Takamitsu Fujimaki

 4 Testicular Germ Cell Tumours – A European and UK Perspective 59 Nikhil Vasdev and Andrew C. Thorpe

Part 2 Scientific Perspectives .

 5 Mouse Models of Testicular Germ Cell Tumors 75 Delphine Carouge and Joseph H. Nadeau

 6 Epigenetic Modifications in Testicular Germ Cell Tumors 107 Christopher J. Payne

 7 Claudins and Germ Cell Tumors 135 Ylermi Soini .

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Published by: Unknown - Sunday, March 31, 2013

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