Open Access Medical Books

TEXTBOOK : MOLECULAR VIROLOGY

MOLECULAR VIROLOGY

Edited by Moses P. Adoga .

180 pages . 
Open Access . 

Since the early experiment conducted by Dmitri Ivanovski in 1892 that demonstrated how filtered sap from diseased tobacco plants had infectious particles that subsequently infected healthy ones and the later naming in 1898 of the infectious particles by Martinus Beijerinck as contagium vivum fluidum, from which the name virus derived, the study of viruses and virus-like agents (Virology) has over the years advanced in experimental depths and sophistications. It was this advancement that led to a molecular dimension to virology with much greater significant discoveries being the continual outcome. This book is therefore, intended to serve as a major
contribution to this fast advancing field of study.
Chapter one discusses HIV-1 reservoirs and latency. The authors treated it against the backdrop that reservoirs have been reported to serve as major impediments to a cure and at the same time offer useful clues for eradication. Researchers concerned with HIV- 1 eradication studies will find this part of the book of utmost importance. In chapter two, the authors did justice to the molecular evolution of hepatitis viruses including their genetic diversities, and further exposed the fact that such evolutionary diversities are an impediment to vaccine initiatives. Users will discover in chapter three the metabolic disorders that can result from hepatitis C virus infection. The authors tried to make the readers understand that although the primary target of hepatitis C virus (HCV) is the liver, metabolic complications have also been associated with its infection. This chapter also did justice to the role of chronic HCV infection in proteinuria, type-2 diabetes,
metabolic syndrome and lipid abnormalities among several other aspects.
Chapter four explores the genome of the influenza C virus and discusses the structure and function of its M gene. Coding strategies of influenza C virus M gene, regulation of M1 and CM2 synthesis, and the role of M gene products in virus replication are also discussed inter alia. Viral vectors and their applications in therapeutic research are discussed in chapter five. The authors treated their applications in neurobiology and
gene therapy, among others. In chapter six, various aspects of avian influenza are discussed with emphasis on why it is cost effective to focus more efforts on preventive measures against spending much more on treatment (when prevention should have cost less). Chapter seven discusses how Japanese encephalitis virus infection can be prevented with bella-donna 200. The authors also reported their research experience
with this product.
Virologists with special interest in insects and all those concerned with agricultural pest studies and control will find the last two chapters of great importance. In chapters eight and nine, the authors discussed how the field dynamics of insect populations can be influenced by viruses that are pathogenic to insects. Treated are the role of baculovirus enhancins in pathogenicity, identification and analysis of the enhancins, their function and how polydnaviruses interact with nucleopolyhedroviruses in Lepidoptera larvae inter alia.
The great contributions in this book by highly experienced scientists including renowned professors are a clear indication that from the first to the last chapters, you are up for a thrilling new insight into Molecular Virology. The publisher, editor and the authors hope that researchers, lecturers and students alike will find this masterpiece an invaluable companion.

Moses P. Adoga
PhD Cellular and Molecular Biology
Bangor University, School of Biological Sciences
UK


CONTENTS OF THE TEXTBOOK :


1 HIV-1 Reservoirs and Latency: 
Critical Barriers and Clues for HIV / AIDS Cure 1
Moses P. Adoga and Grace Pennap

2 Molecular Evolution of 
Hepatitis Viruses 11
Flor H. Pujol, Rossana Jaspe and Héctor R. Rangel

3 Metabolic Aspects of Hepatitis C Virus Infection 33
Jee-Fu Huang, Ming-Lung Yu, Chia-Yen Dai, Wan-Long Chuang and Wen-Yu Chang

4 Influenza C Virus: Structure and 
Function of M Gene and Its Products 63
Yasushi Muraki

5 Viral Vectors in Neurobiology: 
Therapeutic and Research Applications 75
Renata Coura

6 Avian and Pandemic Influenza (API): 
A Prevention-Oriented Approach 93
Muhiuddin Haider and Jared Frank

7 The Role of 'Belladonna 200' in 
the Prevention of Japanese Encephalitis (JE) Virus Infection 111
Bhaswati Bandyopadhyay,Satadal Das, Milan Sengupta, Chandan Saha, Chinta Raveendar, Rathin Chakravarty, Chaturbhuja Nayak Anil Khurana and Krishnangshu Ray

8 Interactions Between Nucleopolyhedroviruses 
and Polydnaviruses in Larval Lepidoptera 125
Vincent D’Amico and James Slavicek

9 Baculovirus Enhancins and Their Role in Viral Pathogenicity 147
James M. Slavicek .


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