Open Access Medical Books



Edited by Rajnikant Mishra .

256 pages . 
Open Access .

Mutagenesis is a powerful method directed towards mutating genes or engineering genome for functional analysis, producing mouse models of human disease, and understanding molecular mechanism of biodiversity at different levels of biological organizations. Several insights have been revealed through studies using experimental models, or in silico, on natural mutations in general and site-specific mutagenesis in particular. However, unified text on recent trends in mutagenesis is poorly available within a single cover. Trust, this book would cater the need of readers who are looking for unified text on mutagenesis and its applications in research and teaching in the area of basic, agricultural or medical sciences.
I express my gratitude to authors for sharing their experience on mutagenesis. I gratefully acknowledge the time and valuable suggestions of reviewers Dr Padmanabh Dwivedi, and Dr Anju Shrivastava. I extend my sincere thanks to my dear students Miss Brij Bharti, Mr Ratnakar Tripathi, Mr Sachin Shukla and Mr Kumar Shubham for their critical help in editing this book.

Rajnikant Mishra, Ph.D
Biochemistry & Molecular Biology Laboratory
Department of Zoology
Banaras Hindu University,Varanasi-221005,


1 Mutagenesis: A Useful Tool for the Genetic Improvement 
of the Cultivated Peanut (Arachis hypogaea L.) 1
Chuan Tang Wang, Yue Yi Tang, Xiu Zhen Wang, Qi Wu, Hua Yuan Gao, Tong Feng, Jun Wei Su, Shu Tao Yu, Xian Lan Fang, Wan Li Ni, Yan Sheng Jiang, Lang Qian and Dong Qing Hu

2 Mono-Ubiquitination 
of Nuclear Annexin A1 and Mutagenesis 13
Fusao Hirata, George B. Corcoran and Aiko Hirata

3 Models for Detection of Genotoxicity 
in vivo: Present and Future 31
Cherie Musgrove and Manel Camps

4 Mitochondrial Mutagenesis in Aging and Disease 51
 Marc Vermulst, Konstantin Khrapko and Jonathan Wanagat

5 Molecular Mechanisms of Action of Antimutagens from 
Sage (Salvia officinalis) and Basil (Ocimum basilicum) 85
Biljana Nikolić, Dragana Mitić-Ćulafić, Branka Vuković-Gačić and Jelena Knežević-Vukčević

6 Chemical Modification of Oligonucleotides: 
A Novel Approach Towards Gene Targeting 113
Hidetaka Torigoe and Takeshi Imanishi

7 The Mutation of Transient Receptor Potential 
Vanilloid 4 (TRPV4) Cation Channel in Human Diseases 141
Sang Sun Kang

8 Bacterial Systems for 
Testing Spontaneous and Induced Mutations 153 
Anna Sikora, Celina Janion and Elżbieta Grzesiuk

9 ENU Mutagenesis in Mice – Genetic Insight 
into Impaired Immunity and Disease 179
Kristin Lampe, Siobhan Cashman, Halil Aksoylar and Kasper Hoebe

10 Mutagenesis in Plant Breeding 
for Disease and Pest Resistance 195
Petra Kozjak and Vladimir Meglič

11 Mutagenesis and 
Temperature-Sensitive Little Machines 221
María Pertusa, Hans Moldenhauer, Sebastián Brauchi, Ramón Latorre, Rodolfo Madrid and Patricio Orio .

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