Open Access Medical Books



Edited by Manish Agarwal .

182 pages .
Open Access .

Osteosarcoma, is the most common malignant primary bone tumor. Though high grade and potentially lethal, it is highly curable. Though a rare cancer, it predominantly affects children and young adults and being highly curable, the treatment strategy has permanent impact on the life of the patient. A plateau has been reached in its outcome but a lot of research is now being aimed at molecular level to find potential targets for treatment. The dissemination of knowledge coupled with availability of affordable chemotherapeutic drugs and prosthesis have improved the outcomes even in the developing world. The necessity of providing low cost treatment has resulted in innovation in strategy and surgical approach.
Osteosarcoma is to orthopaedic oncology what tuberculosis is to infection. Both have varied spectrum of presentation and can mimic a host of conditions. This book is not meant to be a treatise on osteosarcoma. As the title suggests, it is a fresh look at this disease with an aim to update the existing knowledge on etiology, pathology and workup and to provide a look at the chemotherapeutic and surgical strategy.
Importance has also been given to the new research which could potentially change the systemic treatment.
What is also different about this book is that it is online, open access and has been done in a short turnaround time keeping the information very current at time of publication. The authors have published in this field before and many have experience of seeing hundreds of osteosarcomas. This book should be useful to clinicians, researchers as well as students with an interest in the field of osteosarcoma.

Manish Agarwal
Hinduja Hospital, Mumbai,



Part 1 Osteosarcoma Workup .

 1 Histopathology and Molecular Pathology of Bone and Extraskeletal Osteosarcomas 3 Helen Trihia and Christos Valavanis

 2 Imaging Osteosarcoma 41 Ali Nawaz Khan, Durr-e-Sabih, Klaus L. Irion, Hamdan AL-Jahdali and Koteyar Shyam Sunder Radha Krishna

Part 2 Osteosarcoma Treatment .

 3 Misdiagnosis and Mistreatment for Osteosarcoma: Analysis of Cause and Its Strategy 85 Yao Yang and Lin Feng

4 Chemotherapy in Osteosarcoma 93 Kapadia Asha, Almel Sachin and Shaikh Muzammil

 5 Limb Salvage for Osteosarcoma: Current Status with a Review of Literature 109 Manish G. Agarwal and Prakash Nayak

Part 3 Osteosarcoma Research .

6 Bone Formation Deregulations Are the Oncogenesis Keys in Osteosarcomas 139 Natacha Entz-WerlĂ©

 7 The Retinoblastoma Protein in Osteosarcomagenesis 159 Elizabeth Kong and Philip W. Hinds

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Published by: Unknown - Sunday, March 31, 2013


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