Open Access Medical Books

Textbook : VIRAL REPLICATION

VIRAL REPLICATION

Edited by German Rosas-Acosta .

124 pages .
Open Access .

This book is the result of the combined effort of an international panel of experts on different areas of virological research. Therefore, rather than presenting an exhaustive review of a very focused virological area, it provides a collection of in-depth reviews broadly related to the mechanisms of viral replication as applied to various viruses of critical relevance for human or animal disease.
Specifically, this book contains six different chapters. Chapter one, “Influenza A Virus Multiplication and the Cellular SUMOylation System,” summarizes our current knowledge of the mechanisms governing Influenza A transcription and replication, and provides an in depth review of our current knowledge of the interactions established between the cellular SUMOylation system and influenza virus during infection, indicating how knowledge related to this topic may lead to innovative new therapeutic approaches against influenza.
Chapter two, “West Nile Virus: Basic Principles, Replication Mechanism, Immune Response and Important Genetic Determinants of Virulence,” provides a thorough review of our current knowledge of the molecular biology of West Nile Virus, with emphasis on its structure, genome, replication cycle, epidemiology, pathogenesis, and the genetic determinants of viral virulence.
Chapter three, “Hepatitis B Virus Genetic Diversity: Disease Pathogenesis,” gives a general overview of the molecular biology of Hepatitis B virus, with particular emphasis on its mechanisms of replication, the role played by the different proteins encoded by the virus during its life cycle, viral genotypes and sub-genotypes, and their link with pathogenesis in the outcome of viral infection.
Chapter four, “An Overview of the Immune Evasion Strategies Adopted by Different Viruses With Special Reference to Classical Swine Fever Virus,” presents a brief review of the general mechanisms used by viruses to evade the immune responses of their host, with special emphasis on the mechanisms used by Classical Swine Fever Virus.
Chapter five, “Viral Replication Strategies: Manipulation of ER Stress Response Pathways and Promotion of IRES-Dependent Translation,” presents an in-depth review of our current knowledge of ER Stress Response Pathway and how viral infection utilizes this pathway to stimulate cap-independent (IRES-dependent) translation. Furthermore, it provides an overview of the different Internal Ribosomal Entry Sites encoded by viruses, their classification, mechanism of action, and how viruses manipulate the cellular environment to enhance their activity.
And chapter six, “Antiviral Replication Agents,” gives a general overview of antiviral chemotherapeutic agents currently licensed for clinical used and their mechanisms of action, with emphasis on the viral processes and components targeted by them.
This book is aimed at students, scholars, professors, and investigators who are peripherally related to, or somehow intrigued by, the different areas of virology covered in this book, as well as at those individuals with greater expertise and knowledge in the topics herein presented who may want up-to-date in depth reviews related to such topics.
We expect that, in addition to providing excellent reviews in various exciting areas of virological research, this book will also stimulate the type of scientific discussions and ideas that will result in sustained research efforts not only in the specific areas of research covered in this book, but also in other related areas of biomedical research.


German Rosas-Acosta, PhD.
Border Biomedical Research Center (BBRC), 
The University of Texas at El Paso (UTEP),
Department of Biological Sciences, 
The University of Texas at El Paso (UTEP),
USA
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CONTENTS OF THE TEXTBOOK :


1 Influenza A Virus Multiplication 
and the Cellular SUMOylation System 1 Andrés Santos, Jason Chacón and Germán Rosas-Acosta

2 West Nile Virus: Basic Principles, Replication Mechanism, 
Immune Response and Important Genetic Determinants of Virulence 43 George Valiakos, Labrini V. Athanasiou, Antonia Touloudi, Vassilis Papatsiros, Vassiliki Spyrou, Liljana Petrovska and Charalambos Billinis

3 Hepatitis B Virus Genetic Diversity: Disease Pathogenesis 69 MariaKuttikan Jayalakshmi, Narayanan Kalyanaraman and Ramasamy Pitchappan

4 An Overview of the Immune Evasion Strategies 
Adopted by Different Viruses with Special Reference to Classical Swine Fever Virus 83 S. Chakraborty, B.M. Veeregowda, R. Deb, and B.M. Chandra Naik

5 Viral Replication Strategies: 
Manipulation of ER Stress Response Pathways and Promotion of IRES-Dependent Translation 103 Paul J. Hanson, Huifang M. Zhang, Maged Gomaa Hemida, Xin Ye, Ye Qiu and Decheng Yang

6 Antiviral Replication Agents 127 
Zeinab N. Said and Kouka S. Abdelwahab .


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