Open Access Medical Books


Edited by Roman Hajek .

Open Access .
334 pages .

Multiple myeloma is the second most common haematological malignancy. This book does not provide a comprehensive overview of the disease but offers a collection of chapters with in-depth information on distinct hot topics in the diagnostic, research and therapeutic fields.
On the biological side, the authors show plasticity of myeloma cells and describe the innovative models to assess multiple myeloma biology. On the clinical side, the authors analyse current therapeutic development. Pharmacotherapy of multiple myeloma is an example of the fast introduction of scientific discoveries into clinics. The dynamics of testing new drugs for multiple myeloma treatment in clinical trials is breathtaking. Scientific discoveries have uncovered complicated pathogenesis of multiple myeloma; complicated reactions to treatment lead to creation of super cocktails. This strategy is most beneficial for the patient, but it is not yet personalized medicine. The curability of multiple myeloma is a question that is being discussed by the entire professional myeloma world. Regardless of your position in this debate, some professionals are missing the vital point in this debate - the incredible improvement in treatment options. Consequently, improvement of prognosis is a fact which is most important from a patient’s perspective.
This book will be of interest to medical professionals specializing in hematooncology, researchers, as well as many others.

Prof. Roman Hajek
Department of Pathological Physiology,
Faculty of Medicine, Masaryk University,
Czech Republic



 1 Strategies for the Treatment of Multiple Myeloma in 2013: Moving Toward the Cure 1 Roman Hajek

 2 Monoclonal Immunoglobulin 13 Marie-Christine Kyrtsonis, Efstathios Koulieris, Vassiliki Bartzis, Ilias Pessah, Eftychia Nikolaou, Vassiliki Karalis, Dimitrios Maltezas, Panayiotis Panayiotidis and Stephen J. Harding

 3 Innovative Models to Assess Multiple Myeloma Biology and the Impact of Drugs 39 Marina Ferrarini, Giovanna Mazzoleni, Nathalie Steimberg, Daniela Belloni and Elisabetta Ferrero

 4 Heterogeneity and Plasticity of Multiple Myeloma 61 Hana Šváchová, Sabina Sevcikova and Roman Hájek

 5 Immunophenotyping in Multiple Myeloma and Others Monoclonal Gammopathies 93 Lucie Rihova, Karthick Raja Muthu Raja, Luiz Arthur Calheiros Leite, Pavla Vsianska and Roman Hajek

 6 Monoclonal Gammopathy of Undetermined Significance 111 Magdalena Patricia Cortés, Rocío Alvarez, Jessica Maldonado, Raúl Vinet and Katherine Barría

 7 Induction Therapy in Multiple Myeloma 133 Sule Mine Bakanay and Meral Beksac

 8 Allogeneic Hematopoetic Cell Transplantation in Multiple Myeloma 165 Pervin Topcuoglu, Sinem Civriz Bozdag and Taner Demirer

 9 Cellular Immunotherapy Using Dendritic Cells in Multiple Myeloma: New Concept to Enhance Efficacy 179 Je-Jung Lee, Youn-Kyung Lee, Hyun Ju Lee, Sung-Hoon Jung and Thanh-Nhan Nguyen-Pham

 10 Novel Prognostic Modalities in Multiple Myeloma 199 Mariam Boota, Joshua Bornhorst, Zeba Singh and Saad Z. Usmani

 11 Bone Disease in Multiple Myeloma 217 Maja Hinge, Thomas Lund, Jean-Marie Delaisse and Torben Plesner

 12 Rare Manifestations of Multiple Myeloma 241 Artur Jurczyszyn

 13 Pain and Multiple Myeloma 259 Emine Ozyuvaci, Onat Akyol and Tolga Sitilci

 14 Quality of Life Issues of Patients with Multiple Myeloma 275 Klára Gadó and Gyula Domján

 15 Multiple Myeloma in Horses, Dogs and Cats: A Comparative Review Focused on Clinical Signs and Pathogenesis 289 A. Muñoz, C. Riber, K. Satué, P. Trigo, M. Gómez-Díez and F.M.

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Published by: Unknown - Tuesday, April 23, 2013


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