Open Access Medical Books



Edited by Yue Cheng .

230 pages .
Open Access .

suggesting that these regions may contain important genes associated with tumor development.
Cell fusion studies provided the first functional evidence for a class of negatively-acting tumor suppressor genes (TSGs) harbored on certain human chromosomes. Based on Knudson’s “two-hit hypothesis", the first TSG, RB was identified. Since 1980s, many TSGs have been discovered by using different approaches. Accumulated knowledge indicates that TSGs not limited to tumor suppression play critical roles in various biological activities in human cells.
In 20132, InTech published a book called “Tumor Suppressor Genes”, which covers the most important fields, from cell cycle control, signaling pathways, epigenetic regulation, and current challenges to therapeutic applications of known TSGs. Some well-studied TSGs, such as p53 and p16, and their regulatory mechanisms in tumor development are addressed in this book. However, TSG research is a fast growing area, and many novel approaches and findings have been discovered recently. Therefore, it is necessary to publish a new open access book that may provide future directions for TSG studies.
This book, “Future Aspects of Tumor Suppressor Genes”, contains some important areas that were not mentioned in the previous book. The majority of known TSGs were identified from hereditary tumor syndromes. However, more than 90% of human tumors are sporadic cases, so it is always a challenge to identify tumor susceptibility loci in sporadic tumors. Using animal models, authors in this book investigated whether strain-specific allele loss was an important clue to identify tumor suppressors involved in tumor susceptibility, which should be interesting to many researchers. Other basic researches contain investigations of several TSG signaling pathways from different laboratories: START-GAP/DLC family proteins and their molecular pathways involved in the control of cell growth, E2F-mediated tumor suppressive mechanism associated with RB, p53, ARF, p27Kip1 and TAp73 transcription factors, and TSGs in the regulation of receptor tyrosine kinase signaling via a negative feedback loop.
Understanding these signaling regulatory mechanisms may lead to findings of molecular targets for cancer therapy. In recent years, it has been well-accepted that microRNAs are an abundant class of endogenous small RNA molecules that can regulate tumor development.
To reflect the trends of these novel researches, authors in this book present an extensive review for current knowledge of microRNAs that play in the control of tumor growth and therapeutic application.
This book also includes some other fascinating fields and emerging subjects in TSG studies.
For example, the application of Drosophila as a special model for tumor suppression studies is addressed, and future directions used for the pharmacological screening and therapy strategies are also proposed. Natural compounds, such as polyphenols, interfere with the initiation and progression of cancer development via multiple TSG pathways. Recent evidence, demonstrating that these compounds are able to modulate various cellular activities, such as cell cycle arrest, anti-angiogenesis, and metastasis suppression, are summarized in the relevant chapter. Finally, the regulatory role of TSGs, such as p16, p53 and RB, in cell reprogramming, stemness transition process, and signaling networks of these genes during these cellular processes are extensively reviewed, which indicates that TSGs are actively involved in many aspects of stem cell biology and regenerative medicine.

I would like take this opportunity to express my gratitude to all authors and InTech staff for their contributions in this publication project, and I hope that this book will be helpful for students, researchers and clinicians.

Yue Cheng, PhD
Department of Clinical Oncology
The University of Hong Kong



 1 Strain-Specific Allele Loss: An Important Clue to Tumor Suppressors Involved in Tumor Susceptibility 1 Nobuko Mori and Yoshiki Okada

 2 To Grow, Stop or Die? – Novel Tumor-Suppressive Mechanism Regulated by the Transcription Factor E2F 17 Eiko Ozono, Shoji Yamaoka and Kiyoshi Ohtani

 3 MicroRNAs and lncRNAs as Tumour Suppressors 45 Emanuela Boštjančič and Damjan Glavač

 4 Roles of Tumor Suppressor Signaling on Reprogramming and Stemness Transition in Somatic Cells 75 Arthur Kwok Leung Cheung, Yee Peng Phoon, Hong Lok Lung, Josephine Mun Yee Ko, Yue Cheng and Maria Li Lung

 5 Modeling Tumorigenesis in Drosophila: Current Advances and Future Perspectives 97 Fani Papagiannouli and Bernard M. Mechler

 6 Polyphenolic Compounds Targeting p53-Family Tumor Suppressors: Current Progress and Challenges 129 Nelly Etienne-Selloum, Israa Dandache, Tanveer Sharif, Cyril Auger and Valérie B. Schini-Kerth

 7 START-GAP/DLC Family Proteins: Molecular Mechanisms for Anti-Tumor Activities 169 Hitoshi Yagisawa

 8 MIG-6 and SPRY2 in the Regulation of Receptor Tyrosine Kinase Signaling: Balancing Act via Negative Feedback Loops 199 Yu-Wen Zhang and George F. Vande Woude

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Published by: Unknown - Friday, April 12, 2013


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