Open Access Medical Books



Edited by Pinakin Gunvant .

388 pages .
Open Access .

It is difficult to imagine how intellectually gifted individuals, like Leonardo da Vinci, could demonstrate such mastery of so many subjects: art, mathematics and medicine.
Such comprehensive academic proficiency was uncommon in the 15th century, and perhaps is even more rare today. It would be an understatement to say that we live in an era where information is exploding at a rate faster than what can be assimilated.
This means that it is nearly impossible to be specialists in all areas and has, in turn, produced “super specialists” in all fields––including medicine.
This book features a collection of articles authored by various researchers who are super specialists in the pathogenesis, diagnosis and treatment of glaucoma. With such a heterogeneous nature, you may even argue that glaucoma is not one disease, but a group of diseases. A lot is already known about glaucoma, and a lot more has yet to be determined. Likewise, what information we deem to be "fact" today may be questioned and deconstructed by the thought leaders of tomorrow. But, that is the beauty of science and research.
This book summarizes current literature about research and clinical science in glaucoma. By no means is this a comprehensive guide to the subject; rather, it is more of a synopsis and translation of the research conducted by individuals who are known in each of their respective areas.
The book can be divided into two broad sections: basic science and clinical science.
The basic science section examines bench- and animal-modeling research in an attempt to understand the pathogenesis of glaucoma. The clinical science section addresses various diagnostic issues and the medical, laser and surgical techniques used in glaucoma management. We hope that both clinicians and scientists find this work useful and stimulating.
The e-book and open-access model provided by the publishers ensure that the information in this book will be widely circulated and available to everyone who wants to learn. This model echoes the words of Nobel laureate Rabindranath Tagore who wrote the poem given below in his book Gitanjali about 100 years ago:
Where the mind is without fear and the head is held high;
Where knowledge is free; 
Where the world has not been broken up into fragments by narrow domestic walls;

Where words come out from the depth of truth;
Where tireless striving stretches its arms towards perfection;
Where the clear stream of reason has not lost its way into the dreary desert sand of dead habit;
Where the mind is led forward by thee into ever-widening thought and action---
Into that heaven of freedom, my Father, let my country awake.”

My sincere gratitude goes to Subba Gollamudi MD, Eye Specialty Group, Memphis Tennessee; Shelly Gupta MD, faculty The Ohio State University, Columbus, Ohio; and Jasmine Yumori OD, Western University of Health Sciences, Pomona, California. Their expert opinion and assistance in reviewing parts of the book was invaluable.
Additionally, I would like to thank the managing editor, Ms. Petra Zobic and editorial team manager Ms. Anna Nikolic for their assistance throughout the duration of this project. Most importantly, thanks to all the contributing authors whose dedication to research and the art of scientific knowledge dissemination has made this book a reality.

Dr. Pinakin Gunvant
College of Optometry,
Western University of Health Sciences,
Pomona California



Part 1 Basic Science Research in Understanding Pathogenesis in Glaucoma .

 1 Oxidative Stress in Anterior Segment of Primary Open Angle Glaucoma 3 Sergio C. Saccà and Alberto Izzotti

 2 Manipulating Glia to Protect Retinal Ganglion Cells in Glaucoma 25 Denise M. Inman, Caroline B. Lupien and Philip J. Horner

 3 Role of the Matrix Metallo-Proteinases in the Cellular Re-Modeling in a Glaucoma Model System in Rat 51 Claudio De Seta, Nicola Calandrella, Valerio Berardi, Antonio Mazzarelli, Gianfranco Scarsella and Gianfranco Risuleo

 4 Systemic C-Reactive Protein Levels in Normal-Tension Glaucoma and Primary Open-Angle Glaucoma 63 Wei-Wen Su and Shih-Tsung Cheng

 5 Molecular Analysis of Italian Patients with Congenital Glaucoma 71 Italo Giuffre’

Part 2 Review of Evidence in Clinical Management of Glaucoma .

6 Tonometry – Past, Present and Future 85 Elliot M. Kirstein, Ahmed Elsheikh and Pinakin Gunvant

 7 Clustered Trend-Type Analysis to Detect Progression of Visual Field Defects in Patients with Open-Angle Glaucoma 109 Takeo Fukuchi, Takaiko Yoshino, Masaaki Seki, Tetsuya Togano, Hideko Sawada and Haruki Abe

 8 Neovascular Glaucoma 127 Kurt Spiteri Cornish

9 Current Diagnosis and Management of Angle-Closure Glaucoma 145 Rafael Castañeda-Díez, Mariana Mayorquín-Ruiz, Cynthia Esponda-Lamoglia and Oscar Albis-Donado

Part 3 Various Issues Related to Medical Therapy in Glaucoma .

 10 Topical Pressure Lowering Drug: Racial Respond Variation and Pharmacogenetics 171 Ahmad Tajudin Liza-Sharmini

 11 Pharmacogenomics of Open-Angle Glaucoma 187 Stephen G. Schwartz and Tomomi Higashide

 12 Drops, Drops, and More Drops 197 John Walt and Fern Alexander

 13 Pressure Lowering Medications 223 Liza-Sharmini Ahmad Tajudin and Yaakub Azhany

Part 4 Review of Evidence in Using Lasers in Management of Glaucoma .

 14 Selective Laser Trabeculoplasty 257 Silvia Pignatto, Daniele Veritti, Andrea Gabai and Paolo Lanzetta

Part 5 Various Surgical Aspects in Glaucoma .

 15 Combined Approach to Coexisting Glaucoma and Cataract: Choice of Surgical Techniques 275
Brig JKS Parihar, Lt Col Jaya Kaushik, Surg Lt Cdr AS Parihar and Ashwini KS Parihar

 16 A Surgical Technique for Difficult Glaucoma Cases: Combined Cyclectomy/Trabeculectomy 325 Kaya N. Engin and Günay Engin

 17 Glaucoma Surgery with Fugo Blade 337 Daljit Singh and Richard Fugo

 18 Secondary Glaucoma After Vitreoretinal Procedures 361 Lizette Mowatt

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Published by: Unknown - Monday, April 29, 2013


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