Open Access Medical Books



Edited by Helen Reeves, Derek M. Manas and Rajiv Lochan .

184 pages .
Open Access .

Tumours of the liver are frequently benign incidental findings. If malignant, however, the prognosis for those affected is often poor. Malignancies include those which have metastasized to the liver from elsewhere, reflecting advanced stage cancers where cure is rarely possible.
Similarly, primary liver cancer frequently complicates chronic liver disease, which further limits therapeutic options even for disease presenting at a relatively early stage. In fact, primary liver cancer remains one of the few types of cancer where annual mortality figures and incidence are both similar and increasing, reflecting a relative lack of progress in either prevention of the disease or its treatment. Despite these dismal data, there are signs that change is imminent. Surgery remains the goal for treatment of metastatic or primary liver tumours, and advances in surgical techniques as well as tumour ‘downstaging’ offer potential cure to small but ever increasing numbers of individuals. Successful treatment of viral hepatitis has been rewarded in some parts of the globe with falling incidence of primary cancers, while novel means of prevention are also emerging. Imaging modalities have also advanced over the last two to three decades, facilitating surveillance programmes and earlier stage detection of tumours. Medical therapies have markedly improved survival of patients with liver metastases and while the impact of medical therapies for primary liver cancers remains relatively disappointing, small but highly significant advances have been made. In this book, an overview of different liver tumours is presented, focusing particularly on recent developments. As well as an update on epidemiology and risk factors for primary liver cancer, the role of contrast enhanced ultrasound is reviewed, as are the very important roles of anti-viral therapy and the exciting potential of immunotherapy. Management of both primary and metastatic cancers from a surgical perspective is comprehensively covered, including guidance for post therapeutic follow-up. This book serves as an accurate up to date guide for a common and increasing clinical problem. The book will be relevant for all researchers and practitioners involved in the care of patients with liver tumours.

Helen Reeves
Newcastle University, UK

Derek M. Manas
Institute of Transplantation, Newcastle upon Tyne, NHS Hospital Trust, UK
Rajiv Lochan
Freeman Hospital, Newcastle upon Tyne, UK



 1 Epidemiology and Risk Factors 1 Nora Schweitzer and Arndt Vogel

 2 Contrast-Enhanced Ultrasonography (CEUS) of Liver Masses — Principles, Clinical Applications, Drawbacks 13 R. Badea and Simona Ioaniţescu

 3 Role of Anti-Viral Therapy on Hepatitis B Virus (HBV)-Related Hepatocellular Carcinoma (HCC) 39 Charing Ching Ning Chong, Grace Lai Hung Wong, Vincent Wai Sun Wong, Kit Fai Lee, Paul Bo San Lai and Henry Lik Yuen Chan

 4 Immunotherapy for Hepatocellular Carcinoma: Current Status and Future Perspectives 59 Yu Sawada, Kazuya Ofuji, Mayuko Sakai and Tetsuya Nakatsura

 5 Primary Liver Tumours – Presentation, Diagnosis and Surgical Treatment 91 H. Bektas, H. Schrem, M. Kleine, A. Tamac, F.W.R. Vondran, S. Uzunyayla and J. Klempnauer

 6 Post-Therapeutic Follow-Up and Early Detection of Recurrence in Hepatocellular Carcinoma 117 Simona Ioaniţescu, L. Micu, Mariana Mihăilă and R. Badea

 7 Liver Metastases — Surgical Treatment 137 Alejandro Serrablo, Luis Tejedor and Jose-Manuel Ramia

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Published by: Unknown - Monday, April 22, 2013


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