Open Access Medical Books



Edited by Mark B. Zimering .

352 pages . 
Open Access .

Type 2 diabetes is estimated to affect 120 million people worldwide- and according to projections from the World Health Organization this number is expected to double over the next two decades. Novel, cost effective strategies are needed to reverse the global epidemic of obesity which is driving the increased occurrence of type 2 diabetes and to less the burden of diabetic vascular complications. In the current volume, Topics in the Prevention, Treatment and Complications of Type 2 Diabetes experts in biology and medicine from four different continents contribute important information and cutting-edge scientific knowledge on a variety of topics relevant to the management and prevention of diabetes and related illnesses.
In the opening section, Economic burden and Relation to Alzheimer's Disease, Atanasijevic- Kunc & Drinovec use mathematical modeling and simulation to forecast the economic burden from type 2 diabetes in the coming decades. Alzheimer’s disease has been referred to as ‘type 3 diabetes’ because of its increased prevalence in populations having obesity, insulin resistance and dyslipidemia. In two excellent chapters- DiCarlo et al present evidence suggesting that type 2 diabetes has manifestations of a protein misfolding disease akin to several well-known neurodegenerative diseases and then Sung Min Son and colleagues argue in favor of mechanistic links underlying an association between insulin resistance and Alzheimer’s disease.
The section on Treatment starts with a concise review of GLP-1 receptor analogues by Perusicova & Owen. Next, Somsak and colleagues summarize experimental and clinical data supporting the efficacy of new glycomimetic compounds for the treatment of type 2 diabetes in animal models. Ishizuka et al review data showing that the adrenal androgen DHEA can improve glucose sensitivity and protect against the development of diabetes in obese rats. Finally, Cheow Peng Ooi et al summarize the results of clinical trials using various botanical compounds for the treatment of type 2 diabetes.
In a brief section Prevention, McLellan et al present the results of their study of lifestyle interventions in preventing type 2 diabetes. Maki and Rains review existing data on how the consumption of dietary fiber can lower the risk for development of type 2 diabetes.

Finally, the closing section on Complications offers an in-depth, expert treatment on such diverse topics as vitamin B12 deficiency, the microcirculation, hypertriglyceridemic-waist as a predictor of cardiovascular disease, and psychological aspects of type 2 diabetes, all by notable contributors in each field.

Mark B. Zimering, MD, PhD
Chief, Endocrinology
Veterans Affairs New Jersey Healthcare System
East Orange, New Jersey,
Associate Professor of Medicine
University of Medicine and Dentistry of New Jersey,
Robert Wood Johnson Medical School, New Brunswick, New Jersey,



Part 1 Economic Burden & Relation to Alzheimer's Disease .

 1 Burden of Diabetes Type 2 Through Modelling and Simulation 3 Maja Atanasijević-Kunc and Jože Drinovec

 2 Alzheimer’s Disease and Type 2 Diabetes: Different Pathologies and Same Features 29 Marta Di Carlo, Pasquale Picone, Rita Carrotta, Daniela Giacomazza and P.L. San Biagio

 3 Insulin Resistance and Alzheimer’s Disease 53 Sung Min Son, Hong Joon Shin and Inhee Mook-Jung

Part 2 Novel Treatments .

 4 Incretin-Based Treatment Strategy - GLP-1 Receptor Agonists (GLP-1R) or So-Called Incretin Mimetics 77 Jindra Perusicova and Klara Owen

 5 Carbohydrate Derivatives and Glycomimetic Compounds in Established and Investigational Therapies of Type 2 Diabetes Mellitus 103 László Somsák, Éva Bokor, Katalin Czifrák, László Juhász and Marietta Tóth

 6 Effect of Dehydroepiandrosterone on Insulin Sensitivity and Adipocyte Growth in Otsuka Long-Evans Tokushima-Fatty Rats 127 Tatsuo Ishizuka, Kazuo Kajita, Kei Fujioka, Takayuki Hanamoto, Takahide Ikeda, Ichiro Mori, Masahiro Yamauchi, Hideyuki Okada, Taro Usui, Noriko Takahashi, Hiroyuki Morita, Yoshihiro Uno and Atsushi Miura

 7 A Review of Clinical Trials in Emerging Botanical Interventions for Type 2 Diabetes Mellitus 145 Cheow Peng Ooi, Seng Cheong Loke and Tengku-Aizan Hamid

Part 3 Prevention .

 8 Prevention of Diabetes: Effects of a Lifestyle Intervention 163 Kátia Cristina Portero McLellan, Antonio Carlos Lerário and Roberto Carlos Burini

 9 Fiber and Insulin Sensitivity 177 Kevin C. Maki and Tia M. Rains

Part 4 Complications .

 10 Characteristics of Vitamin B12 Deficiency in Adult Chinese Patients with Type 2 Diabetes and the Implication of Metformin 193 Chan Chee Wun Joyce, Chan Hoi Yan Florence, Wong Ho Nam Howard and Yeung Chun Yip

 11 Assessment of Microcirculation and the Prediction of Healing in Diabetic Foot Ulcers 215 Jarrod Shapiro and Aksone Nouvong

12 Association Between the Hypertriglyceridemic-Waist Phenotype in Mothers and in Their Offspring 227 Valeria Hirschler

13 The Bidirectional Relationship Between Psychiatry and Type 2 Diabetes Mellitus 237 Menan Rabie

 14 Type 2 Diabetes Mellitus in Family Practice: Prevention and Screening 269 Philip Evans, Christine Wright, Denis Pereira Gray and Peter Langley

15 Community Participation Model for Prevention and Control of Diabetes Mellitus 293 Víctor Manuel Mendoza-Núñez, María de la Luz Martínez-Maldonado and Elsa Correa-Muñoz

 16 A Novel Approach to Adolescent Obesity in Rural Appalachia of West Virginia: Educating Adolescents as Family Health Coaches and Research Investigators 309 Robert A. Branch, Ann Chester, Cathy Morton-McSwain, Soleh Udin Al Ayubi, Kavitha Bhat Schelbert, Philip Brimson, Shama Buch, Yvonne Cannon, Steve Groark, Sara Hanks, Tomoko Nukui, Petr Pancoska, Bambang Parmanto, Stephanie Paulsen and Elaine Wahl

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Published by: Unknown - Tuesday, April 30, 2013


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