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TEXTBOOK : TRENDS IN CELL SIGNALING PATHWAYS IN NEURONAL FATE DECISION


TRENDS IN CELL SIGNALING PATHWAYS IN NEURONAL FATE DECISION

Edited by Sabine Wislet-Gendebien .

336 pages . 
Open Access .


During the last decades, numerous studies about stem cells and regenerative medicine highlighted new therapeutic approaches to treat several neurological disorders. It is noteworthy that the current optimism over potential stem cell therapies is driven by new understandings of stem cell biolology leading to specific cell fate decision.
The main objective of this book is to offer a general understanding of signaling pathways underlying the capacity of differentiation of several types of stem cells into neurons, during the development. Indeed, in this book, we deeply described TGF-beta signaling, Wnt Signaling, neurotrophin and NF-κ-B signaling and their implication in neuronal fate decision.
The second objective of this book is to understand how those pathways are altered in pathological conditions. We consequently analyzed those pathways in several pathological conditions.
Finally the third objective of this book is to describe advances in cellular therapy that could be use to restore central nervous system dysfunction in pathological conditions, based on new molecular biology findings. Several sources of stem cells and their potential benefits were described in the last part of this book.
Finally, I would like to conclude this preface by expressing my deepest gratitude to all authors who contributed to the elaboration of this book.

Sabine Wislet-Gendebien, PhD
GIGA Neurosciences
University of Liège, 
Belgium


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CONTENTS : 



Section 1 TGF-Beta Signaling and Neuronal Fate Decision .


 1 Role of TGF-β Signaling in Neurogenic Regions After Brain Injury 3 Sonia Villapol, Trevor T. Logan and Aviva J. Symes

 2 Insulin/IGF-Signalling in Embryonic and Adult Neural Proliferation and Differentiation in the Mammalian Central Nervous System 37 Tanja Vogel

 3 The Role of Smad Proteins for Development, Differentiation and Dedifferentiation of Neurons 75 Uwe Ueberham and Thomas Arendt

Section 2 Wnt Signaling and Neuronal Fate Decision .


 4 Wnt Signaling Roles on the Structure and Function of the Central Synapses: Involvement in Alzheimer’s Disease 115 Nibaldo C. Inestrosa and Lorena Varela-Nallar

5 Roles of Wnt/β-Catenin Signaling in Controlling the Dopaminergic Neuronal Cell Commitment of Midbrain and Therapeutic Application for Parkinson’s Disease 141 Liang-Wei Chen

 6 Regulation of Cell Fate in the Brain by GSK3 153 Adam R. Cole

Section 3 Neurotrophin and Neuronal Fate Decision .


 7 Neurotrophin Signaling and Alzheimer’s Disease Neurodegeneration − Focus on BDNF/TrkB Signaling 181 Jenny Wong

Section 4 NF-K-b and Neuronal Fate Decision .


8 NFκB Signaling Directs Neuronal Fate Decision 197 Yonggang Zhang and Wenhui Hu

Section 5 Stem Cells and Signaling Pathways .


 9 Telencephalic Neurogenesis Versus Telencephalic Differentiation of Pluripotent Stem Cells 217 Roxana Nat, Galina Apostolova and Georg Dechant

10 Regulation of Basal and Injury-Induced Fate Decisions of Adult Neural Precursor Cells: Focus on SOCS2 and Related Signalling Pathways 241 Harleen S. Basrai, Kimberly J. Christie and Ann M. Turnley

 11 Neural Stem/Progenitor Cells for Spinal Cord Regeneration 271 Ryan Salewski, Hamideh Emrani and Michael G. Fehlings

 12 Epigenetic Regulation of Neural Differentiation from Embryonic Stem Cells 305 Atsushi Shimomura and Eri Hashino

 13 Neural Fate of Mesenchymal Stem Cells and Neural Crest Stem Cells: Which Ways to Get Neurons for Cell Therapy Purpose? 327 Virginie Neirinckx, Cécile Coste, Bernard Rogister and Sabine Wislet- Gendebien .




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