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TEXTBOOK : CLINICAL EPIDEMIOLOGY OF ACUTE LYMPHOBLASTIC LEUKEMIA - FROM THE MOLECULES TO THE CLINIC

LYMPHOBLASTIC LEUKEMIA

Edited by Juan Manuel Mejia-Arangure .

Open Access .
342 pages .


Clinical Epidemiology of Acute Lymphoblastic Leukemia: From the Molecules to the Clinic, is a book which has the goal of introducing the reader into the principal advances in the molecular biology of acute lymphoblastic leukemia (ALL) with application to the clinic.
There are four sections in the book. The first section is about the hypothesis on the etiology of ALL; two chapters were selected at this point. The model for identifying the etiology of ALL is my personnel viewpoint about the etiology of All, mainly in children. I believe that all cancer in children would have a similar behavior in its etiology, however my principal work as researcher during the last twenty years lies on the etiology of ALL in children, therefore the hypothesis centers specially on this group of disease.
In the second section the pathophysiology of ALL is described in three interesting articles.
Epidemiology of ALL is mentioned in the third section where the review of different topics we want to work with in the future is showed to detail.
Finally where reference is specially made to the participation of molecular rearrangements in the prognostic of ALL, in different countries like Mexico, the molecular diagnostic is not done in all the hospitals that attend children with ALL. It is important that the entire policy marker understands the importance that all patients would be diagnosed with the tools that increased the possibility of a better answer to the treatment. I decided to include malnutrition in this section because in undeveloped countries like Mexico malnutrition would explain the high mortality of ALL, specially in children; however in other parts of the world malnutrition is not an important prognostic factor in the survival of children with ALL.
In the last year the development of the molecular biology has contributed in the advance of the survival of patients with ALL. However, current epidemiological findings have not been able to fully explain the etiology of the ALL. If this is a mystery we need to claim God for an answer, after all “He revealeth the deep and secret things: he knoweth what is in the darkness, and the light dwelleth with him” (Daniel 2:22).
Today the patients with ALL are treated better than in the past however, today we cannot prevent the development of the disease. The cure of ALL increases the family’s and patients´ hope, which is great. However if we can prevent the disease we will reduce the parents´ and patient´s broken heart when children are diagnosed with ALL.
I thank all the contributors, many of whom are long-time friends and co-workers. Others are colleagues with whom I have collaborated, or learned from in the literature. Particular thanks go to Arturo Fajardo who has provide me with invaluable guidance over my years in the IMSS.

I dedicate this book to my wife (Norma Luque) and my son (Yurian Mejia) who are my inspiration and the principal motif of my life.


Dr. Juan Manuel Mejia-Arangure
Pediatric Hospital, Centro Médico Nacional "Siglo XXI",
Mexico


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CONTENTS :


Section 1 Hypothesis on the Etiology of ALL .


 1 Model for Identifying the Etiology of Acute Lymphoblastic Leukemia in Children 3 Juan Manuel Mejía-Aranguré

2 Infectious Etiology of Childhood Acute Lymphoblastic Leukemia, Hypotheses and Evidence 19 Abigail Morales-Sánchez and Ezequiel M. Fuentes-Pananá

Section 2 Pathophysiology of ALL .


 3 Pathophysiology of Acute Lymphoblastic Leukemia 43 M. P. Gallegos-Arreola, C. Borjas-Gutiérrez, G. M. Zúñiga-González, L. E. Figuera, A. M. Puebla-Pérez and J. R. García-González

 4 Multi-Role of Cancer Stem Cell in Children Acute Lymphoblastic Leukemia 75 Dong-qing Wang, Hai-tao Zhu, Yan-fang Liu, Rui-gen Yin, Liang Zhao, Zhi-jian Zhang, Zhao-liang Su, Yan-Zhu, Hui-qun Lu, Juan Hong and Jie Zhang

 5 Adult T-Cell Leukemia/Lymphoma (ATL): Pathogenesis, Treatment and Prognosis 87 Shoko Kobayashi and Shigeki Iwasaki

Section 3 Epidemiology of ALL .

 6 Etiological Research of Childhood Acute Leukemia with Cluster and Clustering Analysis 115 David Aldebarán Duarte-Rodríguez, Richard J.Q. McNally, Juan Carlos Núñez-Enríquez, Arturo Fajardo-Gutiérrez and Juan Manuel Mejía-Aranguré

 7 Sociodemographic and Birth Characteristics in Infant Acute Leukemia: A Review 145 ML Pérez-Saldivar, JM Mejía-Aranguré, A Rangel-López and A Fajardo Gutiérrez

 8 Infection During the First Year of Life and Acute Leukemia: Epidemiological Evidence 171 Janet Flores-Lujano, Juan Carlos Núñez-Enríquez, Angélica Rangel- López, David Aldebarán-Duarte, Arturo Fajardo-Gutiérrez and Juan Manuel Mejía-Aranguré

Section 4 Prognostic of ALL .


 9 Genetic Markers in the Prognosis of Childhood Acute Lymphoblastic Leukemia 193 M.R. Juárez-Velázquez, C. Salas-Labadía, A. Reyes-León, M.P. Navarrete-Meneses, E.M. Fuentes-Pananá and P. Pérez-Vera

10 Survival of Patients with Acute Lymphoblastic Leukemia 237 Jorge Organista-Nava, Yazmín Gómez-Gómez, Berenice Illades- Aguiar and Marco Antonio Leyva-Vázquez

 11 Bone Marrow Transplantation (BMT) in Philadelphia-Positive Acute Lymphoblastic Leukemia (Ph+ ALL) 265 Jorge Milone and Enrico Alicia

 12 Alterations of Nutritional Status in Childhood Acute Leukemia 277 Alejandra Maldonado-Alcázar, Juan Carlos Núñez-Enríquez, Carlos Alberto García-Ruiz, Arturo Fajardo-Gutierrez and Juan Manuel Mejía-Aranguré

 13 Acute Lymphoblastic Leukemia (ALL) Philadelphia Positive (Ph1) (Incidence Classifications, Prognostic Factor in ALL Principles of ALL Therapy) 297 Alicia Enrico and Jorge Milone

 14 Invasive Fungal Infections in ALL Patients 317 Roman Crazzolara, Adrian Kneer, Bernhard Meister and Gabriele Kropshofer





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