Open Access Medical Books



Edited by Mohammad Shamsul Ola .

336 pages . 
Open Access . 

During the past few decades great progress has been made in our understanding of pathophysiology, management and treatment of diabetic retinopathy. However, diabetic retinopathy still remains the leading cause of blindness among working adults worldwide. The goal of the book is to provide an update on latest developments in the understanding of pathophysiology of the disease, diagnosis and recent treatments strategies for physicians, ophthalmologists, researchers and medical students.
This book covers topics ranging from pathophysiology to clinical aspects of DR and emerging treatments and concepts in diabetic retinopathy. The first section serves as a description of current understanding of the cellular and molecular mechanism of pathophysiology of diabetic retinopathy, in order to develop possible therapeutic strategies. The second section describes general pathogenic concepts of inflammation and angiogenesis. The third section describes clinical aspects and modern diagnostic features. The fourth part discusses recent concepts and emerging treatment strategies relating to the management of diabetic retinopathy. The originality and style of the text by authors have been kept intact, although some aspects overlap in more than one chapter which is justified by their unique approach and interpretation.
I am very grateful to all the contributors who have worked very hard to make this book a reality. I would also like to thank staff at INTECH, especially Mr. Igor Babic, Publishing Manager and the technical team who did a great job working together on this book. I hope this book will provide a resource for advancing understanding, as well as improving diagnosis and treatment strategies in the effort to help numerous patients who suffer from DR and are threatened by visual loss.

Mohammad Shamsul Ola
Department of Ophthalmology, College of Medicine, King Saud University, Riyadh,
Kingdom of Saudi Arabia



Part 1 Pathophysiology/Basic Research .

 1 Cellular and Molecular Mechanism of Diabetic Retinopathy 3 Mohammad Shamsul Ola and Mohd Imtiaz Nawaz

 2 Gluco-Oxidation of Proteins in Etiology of Diabetic Retinopathy 31 Mohd Wajid Ali Khan, Kamalpreet Banga and Wahid Ali Khan

 3 Diabetic Retinopathy 53 Carlos César Lopes De Jesus

 4 The Molecular Pathogenesis of Diabetic Retinopathy - A Spectrum of Pathology Caused by the Disruption of Inner Blood-Retinal Barrier 67 Byung Joo Lee, and Jeong Hun Kim

 5 Inner Blood-Retinal Barrier Transporters: Relevance to Diabetic Retinopathy 91 Yoshiyuki Kubo and Ken-ichi Hosoya

 6 Fibrovascular Membranes Associated with PDR: Development of Molecular Targets by Global Gene Expression Profiling 109 Shigeo Yoshida, Keijiro Ishikawa, Mitsuru Arima, Ryo Asato, Yukio Sassa and Tatsuro Ishibashi

Part 2 Inflammation and Angiogenesis .

7 Inflammation and Diabetic Retinopathy 125 Hongbin Lü

 8 Immunological Risk Factors for the Development and Progression of Diabetic Retinopathy 137 Katarzyna Zorena, Dorota Raczyńska, and Krystyna Raczyńska

 9 Inflammation and Angiogenesis in Diabetic Retinopathy 163 Ying Yang, Ying Zhang and Yiping Li

Part 3 Clinical Aspects of Diabetic Retinopathy and Retinal Functions .

 10 Diabetic Macular Edema 193 Christina Antonopoulos and Manju Subramanian

 11 The Effect of Diabetes Mellitus on Retinal Function 207 Zvia Burgansky-Eliash

 12 Optical Coherence Tomography Findings in Diabetic Macular Edema 225 Desislava Koleva-Georgieva

 13 Preventing Diabetic Retinopathy: Red Lesions Detection in Early Stages 249 C. Mariño, J. Novo, N. Barreira and M.G. Penedo

Part 4 Emerging Treatments and Concepts in Diabetic Retinopathy .

 14 Treatment of Diabetic Macular Edema – Latest Therapeutic Developments 273 Yeon Sung Moon and Na Rae Kim

 15 Prophylactic Medical Treatment of Diabetic Retinopathy 291 Akihiro Kakehashi, Ayumi Ota, Fumihiko Toyoda, Nozomi Kinoshita, Hiroko Yamagami, Hiroto Obata, Takafumi Matsumoto, Junichi Tsuji, Yoh Dobashi, Wilfred Y. Fujimoto, Masanobu Kawakami and Yasunori Kanazawa

 16 Calcium Dobesilate in Prevention and Treatment of Diabetic Retinopathy 305 Oldřich Farsa

 17 The Role of Sex Hormones in Diabetic Retinopathy 331 Jeffery G. Grigsby, Donald M. Allen, Richard B. Culbert, Gerardo Escobedo, Kalpana Parvathaneni, Brandi S. Betts and Andrew T.C. Tsin

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Published by: Unknown - Monday, April 29, 2013


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    - The Diabetic Retinopathy