Open Access Medical Books



Edited by Pierre Vereecken .

308 pages .
Openn Access .

Since the middle of the 20th century, the incidence of skin cancers such as malignant melanoma is increasing most in the Caucasian population, doubling every 10 years to reach the current rate of 10-15 new cases per year per 100,000 inhabitants. Epidemiological models suggest that prediction is that now a person out of 75 is likely to develop a melanoma in his lifetime. Cutaneous carcinomas are also more frequent.
Along with the increased incidence, increased mortality secondary to melanoma was observed in the second half of the twentieth century, followed by a stabilization probably related to efforts in primary and secondary prevention. Therapeutic advances in this area have been quite limited until recently , despite the enthusiasm generated by clinical trials of immunotherapy, and encourage further efforts to organize prevention and screening compaigns.
Prevention and detection of skin cancer and melanoma in particular are important public health goals in order to decrease the impact of these frequent tumours in young patients.
These objectives require particularly strong solidarity between GPs and dermatologists, both in firstline for the evaluation of the skin of patients and to detect their risk factors.
Despite the fact that new recent progress in skincancer treatment have been described, and that new targeted molecules or new therapeutic procedures help our patients, new insights regarding skin biology are also needed to develop new strategies. Moreover interactions between dermatologists and oncologists are mandatory: many targeted therapies developed to treat systemic malignancies have shown important efficacy for the treatment of both cutaneous malignancies and non-malignant skin disease, such as Hedgehog inhibition for basal cell carcinoma and Rituximab for Pemphigus Vulgaris.
This Highlights in Skincancer written by leading experts in their field synthesize common skincancer topics in clinics and research. It is not a guide intended to be a comprehensive and exhaustive review of all the aspects of dermato-oncology but really a companion that should help the clinicians and researchers to find important and specialized information in this field. It is also an awareness of the close collaboration that must exist between dermatologists and medical oncologists in the management of our patients.

Pierre Vereecken, MD, PhD
Cliderm, European Institute for Dermatology Practice and Research,
Chirec Cancer Institute, Brussels, Belgium



 1 Incidence of Melanoma and Non-Melanoma Skin Cancer in the Inhabitants of the Upper Silesia, Poland 1 Małgorzata Juszko-Piekut, Aleksandra Moździerz, Zofia Kołosza, Magdalena Królikowska-Jerużalska, Paulina Wawro-Bielecka, Grażyna Kowalska-Ziomek, Dorota Olczyk and Jerzy Stojko

 2 Serum Markers in Clinical Management of Malignant Melanoma 27 Pierre Vereecken

 3 An Overview of Important Genetic Aspects in Melanoma 43 Rohinton S. Tarapore

 4 Current Management of Malignant Melanoma: State of the Art 67 Zekayi Kutlubay, Burhan Engin, Server Serdaroğlu and Yalçın Tüzün

 5 About Suncare Products 127 C. Couteau and L. Coiffard

 6 Malignancy in Relation to Autoimmune Blistering Dermatoses: Molecular and Clinical Aspects 159 Paweł Pietkiewicz, Justyna Gornowicz-Porowska, Monika Bowszyc- Dmochowska and Marian Dmochowski

 7 Skin Cancer Prevention Strategies 211 Lisa Passantino, Max Costa and Mary Matsui

 8 Photodynamic Therapy for Non-Melanoma Skin Cancer 233 Cintia Teles de Andrade, Natalia Mayumi Inada, Dora Patricia Ramirez, Vanderlei Salvador Bagnato and Cristina Kurachi

 9 Skin Cancer Screening 249 Carolyn J. Heckman, Susan Darlow, Teja Munshi and Clifford Perlis

 10 The Role of Furin in the Development of Skin Cancer 271 Rethika Ravi and Terrence J Piva 

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Published by: Unknown - Monday, April 22, 2013


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