Open Access Medical Books

TEXTBOOK : THE MYSTERY OF GLAUCOMA


Edited by Tomas Kubena and Martina Kofronova .

362 pages .
Open Access .


Since long ago scientists have been trying hard to show up the core of glaucoma. To its understanding we needed to penetrate gradually to its molecular level. The newest pieces of knowledge about the molecular biology of glaucoma are presented in the first section.
The second section deals with the clinical problems of glaucoma. Ophthalmologists and other medical staff may find here more important understandings for doing their work. What would our investigation be for, if not owing to the people’s benefit?
The third section is full of new perspectives on glaucoma. After all, everybody believes and relies – more or less – on bits of hopes of a better future. Just let us engage in the mystery of glaucoma, to learn how to cure it even to prevent suffering from it.
Each information in this book is an item of great importance as a precious stone behind which genuine, through and honest piece of work should be observed.
It is a point of honour to edit such a book.

Tomas Kubena, M.D.
Head of the Glaucoma service, Zlin, Czech Republic

Martina Kofronova, M.D.
Glaucoma service, Zlin, Czech Republic

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CONTENTS :



Part 1 Molecular Biology .


 1 Evidence of Oxidative Stress Damage in Glaucoma 3 Sandra M Ferreira, Claudia G Reides, Fabián S Lerner and Susana F Llesuy

 2 Differential Effects of Elevated Hydrostatic Pressure on Gene Expression and Protein Phosphorylation in Optic Nerve Head Astrocytes 19 Thomas J. Lukas, Pan Du, Haixi Miao and Simon Lin

 3 Homocysteine in the Pathogenesis of Chronic Glaucoma 41 Mustafa R Kadhim and Colin I Clement

 4 Expression of Metabolic Coupling and Adhesion Proteins in the Porcine Optic-Nerve Head: Relevance to a Flow Model of Glaucoma 61 Francisco-Javier Carreras, David Porcel, Francisco Rodriguez-Hurtado, Antonio Zarzuelo, Ignacio Carreras and Milagros Galisteo

 5 Anatomical and Molecular Responses Triggered in the Retina by Axonal Injury 91 Marta Agudo-Barriuso, Francisco M. Nadal-Nicolás, Guillermo Parrilla-Reverter, María Paz Villegas-Pérez and Manuel Vidal-Sanz

 6 Neuroprotective Agents in Glaucoma 115 Eleni Bagli and George Kitsos


Part 2 Optic Nerve Head and Nerve Fiber Layer .


 7 The Optic Nerve in Glaucoma 147 Ivan Marjanovic

 8 The use of Confocal Scanning Laser Tomography in the Evaluation of Progression in Glaucoma 171 Liamet Fernández Argones, Ibraín Piloto Díaz, Marerneda Domínguez Randulfe, Germán A. Álvarez Cisneros and Marcelino Río Torres

 9 Nerve Fiber Layer Defects Imaging in Glaucoma 187 Kubena T., Kofronova M. And Cernosek P.

 10 Optic Neuropathy Mimicking Normal Tension Glaucoma Associated with Internal Carotid Artery Hypoplasia 199 Kyoko Shidara and Masato Wakakura

 11 Optic Nerve Head Blood Flow in Glaucoma 209 Tetsuya Sugiyama, Maho Shibata, Shota Kojima and Tsunehiko Ikeda


Part 3 New Possibilities and Genetics .


 12 Measurement of Anterior Chamber Angle with Optical Coherence Tomography 221 De Orta-Arellano F, Muñoz-Rodriguez P and Salinas-Gallegos JL

 13 Association of TNF-and TNF- Gene Polymorphisms with Primary Open Angle and Primary Angle Closure Glaucoma 229 Najwa Mohammed Al- Dabbagh, Nourah Al-Dohayan, Abdulrahman Al-Asmari, Misbahul Arfin and Mohammad Tariq

 14 Immune Modulation in Glaucoma – Can Manipulation of Microglial Activation Help? 257 Kin Chiu, Kwok-Fai So and Raymond Chuen-Chung Chang

 15 Stem Cell Based Therapies for Glaucoma 269 Hari Jayaram, Silke Becker and G. Astrid Limb

 16 Functional and Structural Evaluation of Retrobulbar Glaucomateus Damage 293 Kaya N Engin

 17 Central Changes in Glaucoma: Neuroscientific Study Using Animal Models 307 Kazuyuki Imamura, Masamitsu Shimazawa, Hirotaka Onoe, Yasuyoshi Watanabe, Kiyoshi Ishii, Chihiro Mayama, Takafumi Akasaki, Satoshi Shimegi, Hiromichi Sato, Kazuhiko Nakadate, Hideaki Hara and Makoto Araie

18 Using Artificial Neural Networks to Identify Glaucoma Stages 331 Gustavo Santos-García and Emiliano Hernández Galilea





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