Open Access Medical Books

TEXTBOOK : ADVANCES IN THE SCIENTIFIC EVALUATION OF BLADDER CANCER AND MOLECULAR BASIS FOR DIAGNOSIS AND TREATMENT


BLADDER CANCER

Edited by Raj Persad and Weranja Ranasinghe .

138 pages .
Open Access .


Bladder cancer is the sixth most common cancer in the world affecting more than 300,000 men and women worldwide. The diagnosis of bladder cancer not only places a significant personal burden on individuals suffering with the disease (with regular need for surveillance and potential for surgery/radiotherapy) but also has a huge economic and psychosocial and psychosexual impact.
This book is a collection of articles by experts in the field of bladder cancer. It summarises the vast breadth of current knowledge of the molecular processes and the genetic and epigenetic modulation involved in bladder carcinogenesis of the bladder, carcinoma in-situ and the current treatment modalities of bladder cancer.
Tobacco smoking and also a number of occupational carcinogens have been linked to bladder cancer. However the mechanisms involved in the carcinogenesis process are complex and involve multiple steps. Thus, the mechanisms behind DNA damage, regulatory pathways and genetic and epi-genetic modulation leading to bladder carcinogenesis are discussed, highlighting the molecular targets of chemotherapy.
Focus has been placed on carcinoma-in situ of the bladder, an under emphasised but potentially aggressive and fatal form of pre-cancer which is increasing in incidence. Thus an overview of this condition discussing the epidemiology, risk factors, presentation and the management has been included.
Furthermore, this book also discusses the treatment of muscle invasive disease, immunotherapy and advances in molecular signalling pathways with future therapeutic potential. Therefore the roles of adjuvant and neo-adjuvent chemotherapy as well as other agents used in muscle invasive bladder cancer and immune therapy have been included. We believe that this book will provide an excellent overview of the molecular mechanics underlying bladder carcinoma and their role in current and future therapy and would be integral for clinicians and researchers in the field of bladder cancer.

Professor Raj Persad. 
MBBS, ChM, FRCS, FRCS (Urol), FEBU.
Spire Bristol Hospital, UK

Mr. Weranja Ranasinghe 
MBChB, MRCSED.
Cabrini Hospital, Melbourne, Australia


-->

CONTENTS OF THE TEXTBOOK : 





 1 Genetic Instability in Normal-Appearing and Tumor Urothelium Cells and the Role of the TP53 Gene in the Toxicogenomic Effects of Antineoplastic Drugs 1 Daisy Maria Favero Salvadori and Glenda Nicioli da Silva

 2 The Crosstalk of c-MET with Related Receptor Tyrosine Kinases in Urothelial Bladder Cancer 21 Sheng-Hui Lan, Shan-Ying Wu, Giri Raghavaraju, Nan-Haw Chow and Hsiao-Sheng Liu

 3 Loss of Imprinting as an Epigenetic Marker in Bladder Cancer 41 Mariana Bisarro dos Reis and Cláudia Aparecida Rainho

 4 The Changing Incidence of Carcinoma In-Situ of the Bladder Worldwide 69 Weranja Ranasinghe and Raj Persad

 5 Autologous Immunotherapy as a Novel Treatment for Bladder Cancer 85 Martin C. Schumacher and Amir M. Sherif

 6 Metastasis After Primary Treatment — Peri-Operative and Bladder-Preservation Therapy in Muscle Invasive Diseases 107 Yasuyoshi Miyata and Hideki Sakai






You've just read an article category Oncology and Hematology / Radiology and Diagnostics by title TEXTBOOK : ADVANCES IN THE SCIENTIFIC EVALUATION OF BLADDER CANCER AND MOLECULAR BASIS FOR DIAGNOSIS AND TREATMENT. You can bookmark this page URL http://www.openaccessbooks.com/2013/05/TEXTBOOK-ADVANCES-SCIENTIFIC-EVALUATION-BLADDER-CANCER-MOLECULAR-BASIS-DIAGNOSIS-TREATMENT.html. Thank you!
Published by: younes younes - Thursday, May 23, 2013

No comments yet "TEXTBOOK : ADVANCES IN THE SCIENTIFIC EVALUATION OF BLADDER CANCER AND MOLECULAR BASIS FOR DIAGNOSIS AND TREATMENT"

Post a Comment