Open Access Medical Books

TEXTBOOK : AFTER THE KIDNEY TRANSPLANT – THE PATIENTS AND THEIR ALLOGRAFT

KIDNEY TRANSPLANT

Edited by Jorge Ortiz and Jason André .

Open Access .
398 pages .


There are many obstacles in kidney transplantation. For the transplant team, there is the balance between immunosuppression to aid in the recipient’s tolerance of the allograft and the infection risk of a suppressed immune system. These potential long term complications of kidney transplantation are relatively well known, but there are several more complications that patients and families do not consider when preparing themselves for a kidney transplant.
A few of the more common opportunistic infections are investigated in this book to discuss the workup and treatment for these pathogens. These include viral infections like CMV and fungal infections like Cryptococcus. Special attention is also paid to the phenomenon of Posttransplant Lymphoproliferative Disorder (PTLD) and the incidence after kidney transplantation. This is a devastating disease that has serious
implications on the transplant recipient. A great deal of research has been devoted to PTLD and its treatment. This book helps the reader to understand the importance of PTLD and its causes, implications, and possible future direction of research.
Unfortunately, some of the original problems that patient’s have that required a kidney transplant are not cured by the transplantation. As a result, these very same causes of kidney dysfunction in the native kidneys affect the new allograft. A prime example of this is focal segmental glomerulonephritis (FSGS). This is a topic of great interest because recurrent FSGS can lead to allograft failure and the need for a new kidney after transplantation. From this book, the reader will understand why FSGS in particular is such an important disease, and what recurrent FSGS means for the patient and the transplant team.
To have a successful kidney transplantation, the patient’s body must be fooled into believing the allograft is not foreign tissue. This requires powerful immunosuppression therapy which can greatly affect the overall homeostasis of the recipient. New onset diabetes, depression, sexual dysfunction, seizures, anemia and bone disease are a few of the examples that are investigated in this book. From reading this, the reader will begin to understand the sacrifices that must be made by the patient in transplantation.

The final hurdle for the transplant patient is dealing with chronic issues with his or her allograft. The kidney that the patient received over time will start to fail due to several factors that contribute to allograft dysfunction. This book delineates the work up as well as the causes for chronic allograft dysfunction. Finally, there is some time spent on pediatric allograft function as well as delayed graft function to give the reader the full spectrum of potential allograft complications for the recipient. After reading this book, the reader will understand some of the sacrifices that the transplant recipient makes in order to receive his or her kidney and the long term dedication that is needed for success. Although the benefits of attempting a kidney transplant far outweigh downfalls of the long term sequelae, kidney transplantation is not a benign procedure. It is the hope of these authors that the reader will leave with a sense of understanding towards the kidney recipients.

Dr. Jorge Ortiz
Albert Einstein Medical Center
Philadelphia, PA
USA

Dr. Jason André
Albert Einstein Medical Center
Philadelphia, PA
USA


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CONTENTS : 



Part 1 Infections and Kidney Transplantation .


 1 Infectious Complications in Kidney Transplantation 3 Amr El-Husseini and Rashad Hassan

 2 Handling of Fungal Infections in Patients with Chronic Immunosuppression Post Renal Transplant 47 Ewa Swoboda-Kopec, Irina Netsvyetayeva, Magdalena Sikora, Mariusz Jasik and Piotr Fiedor

 3 CMV Infection in CMV-Seropositive Kidney Transplant Recipients 67 Jong Man Kim and Sung Joo Kim

 4 Posttransplant Lymphoproliferative Disorders Following Kidney Transplantation 79 Daan Dierickx

 5 Post-Trasplant Lymphoproliferative Disorders (PTLD) in Adult Kidney Trasplantated Patients 109 Savina Aversa, Silvia Stragliotto, Fabio Canova, Boso Caterina and Marino Dario

Part 2 Glomerulonephritis .


 6 Focal Segmental Glomerulosclerosis (FSGS) Recurrence in Kidney Allograft Recipients 127 Oktawia Mazanowska and Dorota Kamińska

 7 Therapeutic Approach to Focal and Segmental Glomerulosclerosis (FSGS) Recurrence in Kidney Transplant Recipients 141 Guillaume Canaud, Frank Martinez and Christophe Legendre

 8 Post-Transplant Glomerulonephritis in Live-Donor Renal Transplant Recipients: Clinical Course and Risk Factors 151 Ahmed Akl, Hany Adel and Ehab Wafa

Part 3 Kidney Transplant Associated Disease .


 9 Psychological Aspects of Kidney Transplantation 171 Magdalena Trzcinska and Zbigniew Włodarczyk

 10 Characteristics of Anaemia Management in Patients with Chronic Kidney Disease 181 Zvonimir Puretic

 11 Post Transplant Anaemia 195 Bhadran Bose and David Mudge

 12 New Onset Diabetes After Solid Organ Transplantation 205 Phuong-Thu T. Pham, Phuong-Mai T. Pham, Parikh S, Son V. Pham, Phuong-Anh T. Pham and Phuong-Chi T. Pham

 13 Sexual and Reproductive Function in Chronic Kidney Disease and Effect of Kidney Transplantation 229 Mahboob Lessan-Pezeshki and Shirin Ghazizadeh

 14 Management of Bone Disease in Kidney Transplant Recipients 253 Rubin Zhang and Brent Alper

 15 Hypertension in the Kidney Transplant Recipient 267 Heather H. Jones and Daniel J. Salzberg

 16 Diagnosis and Treatment of Status Epilepticus in a Pediatric Renal Recipient 279 Gao Hong-jun, Luo xiangdong, Liang Taisheng, Liang Fangfang et al.

Part 4 Graft Function .


 17 Chronic Allograft Nephropathy 297 Harzallah Kais

 18 Antibody-Mediated Kidney Allograft Rejection 323 Xu Haiyan and He Xiaozhou

 19 Pathogenesis and Preventive Strategies of Chronic Dysfunction of Renal Allograft 335 Wenqian Huo, Keqin Zhang, Chengguo Ge, Gang Wu, Fengshuo Jin, Gang Yuan and Qiansheng Li

 20 Delayed Graft Function 357 Qiansheng Li, Wenqian Huo, Keqin Zhang, Gang Wu, Fengshuo Jin, Xi Lin, Xiaojiang Jiang and Dong Gao

 21 Factors Related to Graft Outcome in Pediatric Renal Transplantation: a Single Center Study 367 Jean Herman and Rita Van Damme-Lombaerts





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