Open Access Medical Books



Edited by Masanori Hirota .

264 pages .
Open Access .

At the moment, aortic stenosis (AS) is the most prevalent valvular disease in the developed countries. Pathological and molecular mechanisms of AS have been investigated in many aspects, and new therapeutic devices, such as trans-catheter aortic valve implantation, have been developed as a less invasive treatment for highrisk patients. Due to advanced prevalent age of AS, further research results and technology are required to treat elderly patients for longer life expectancy.
This book is an effort to present an up-to-date account of existing knowledge, involving recent development in this field. There are 15 chapters written by several expert researchers and clinicians, including cardiologists, cardiac surgeons, pediatricians, physiologists, pathologists and immunologists. These opinion leaders described details of established knowledge, as well as newly recognized advances associated with diagnosis, treatment and mechanism in their speciality. This book will enable close intercommunication to another field and collaboration technology for new devices. We hope that it will be an important source, not only to clinicians, but also to general practitioners, contributing to development of better therapeutic adjuncts in the

Masanori Hirota, MD, PhD
Department of Cardiovascular Surgery,
Hayama Heart Center, Kanagawa,



Part 1 Introduction .

 1 Aortic Stenosis - New Insights in Stenosis Progression and in Prevention 3 Parolari Alessandro, Trezzi Matteo, Merati Elisa, Filippini Sara and Alamanni Francesco

Part 2 Etiology and Pathophysiology .

 2 Aortic Stenosis: Geriatric Considerations 25 Petar Risteski, Andreas Zierer, Nestoras Papadopoulos, Sven Martens, Anton Moritz and Mirko Doss

 3 Pathophysiologic Mechanisms of Age – Related Aortic Valve Calcification 33 Alexandros Alexopoulos, Nikolaos Michelakakis and Helen Papadaki

Part 3 Diagnosis and Prognosis .

 4 Asymptomatic Aortic Stenosis - Prognosis, Risk Stratification and Follow-Up 51 Paoli Ursula and Dichtl Wolfgang

 5 Stress Testing in Patients with Asymptomatic Severe Aortic Stenosis 67 Asim M. Rafique, Kirsten Tolstrup and Robert J. Siegel

 6 Analog Simulation of Aortic Stenosis 75 M. Sever, S. Ribarič, F. Runovc and M. Kordaš

Part 4 Surgical and Interventional Treatments .

 7 Minimally Invasive Aortic Valve Surgery - New Solutions to Old Problems 91 Juan Bustamante, Sergio Cánovas and Ángel L Fernández

 8 Technical Modifications for Patients with Aortic Stenosis and Calcified Ascending Aorta During Aortic Valve Replacement 115 Masanori Hirota, Joji Hoshino, Yasuhisa Fukada, Shintaro Katahira, Taichi Kondo, Kenichi Muramatsu and Tadashi Isomura

 9 Transcatheter Aortic Valve Implantation: New Hope for Inoperable and High-Risk Patients 131 Kentaro Hayashida and Thierry Lefèvre

 10 Management of Congenital Aortic Stenosis by Catheter Techniques 153 Mehnaz Atiq

Part 5 Molecular Considerations in Aortic Stenosis .

 11 Proteomics - A Powerful Tool to Deepen the Molecular Mechanisms of Aortic Stenosis Disease 167 Felix Gil-Dones, Fernando de la Cuesta, Gloria Alvarez-Llamas, Luis R. Padial, Luis F. López-Almodovar, Tatiana Martín-Rojas, Fernando Vivanco and Maria G. Barderas

 12 The Inflammatory Infiltrate in Calcific Aortic Stenosis is Characterized by Clonal Expansions of T Cells and is Associated with Elevated Proportions of Circulating Activated and Effector Memory CD8 T Cells 187 Robert Winchester and Susheel Kodali

 13 Natriuretic Peptides in Severe Aortic Stenosis - Role in Predicting Outcomes and Assessment for Early Aortic Valve Replacement 203 Aaron Lin and Ralph Stewart

 14 Cellular and Neuronal Aspects in Aortic Stenosis 221 J. Ker and WFP Van Heerden

Part 6 Associated Disorders with Aortic Stenosis .

 15 Severe Calcific Aortic Valve Stenosis and Bleeding: Heyde's Syndrome 231 Giampaolo Zoffoli, Domenico Mangino, Andrea Venturini, Angiolino Asta, Alberto Terrini, Chiara Zanchettin, Francesco Battaglia and Elvio Polesel

 16 Hybrid Procedure in Neonatal Critical Aortic Stenosis and Borderline Left Heart: Buying Time for Left Heart Growth 239 Ward Y. Vanagt, Stephen C. Brown and Marc Gewillig

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Published by: Unknown - Tuesday, May 7, 2013


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