Open Access Medical Books



Edited by Elizabeth Sapey .

270 pages .
Open Access .

Asthma is a common, chronic and potentially debilitating disease. It is diagnosed currently on clinical grounds with a combination of symptoms (intermittent breathlessness, wheeze and cough) associated with variable airflow obstruction, which is classically reversible (by bronchodilation).
The heterogeneity of asthma clinically is likely to be due to differences in the cause and the inflammatory signal present in individual groups of patients. Predisposing environmental factors (where known) vary between individuals and across countries, depending on antigenic load. However, not all patients with asthma demonstrate atopy or allergy, and other immune responses are thought important in some patient groups.
It is becoming more recognised that there are specific patient phenotypes in asthma that are associated with differing patterns of disease progression, varying responses to treatment and these are likely to be driven by different genetic susceptibility factors leading to specific inflammatory outputs. Our current understanding of such factors is limited.
This book focuses on emerging theories of the immunological drivers of asthma, how these relate to different patient phenotypes, and how these can be utilised to diagnose asthma more accurately and treat asthma more effectively.
The editors would like to thank the authors for their contributions and we very much hope this book increases the interest in asthma research.

Dr Elizabeth Sapey
Centre for Translational Inflammation Research
University of Birmingham
United Kingdom


Part 1 of the Textbook : Asthma – Diagnosis, Prevalence and Progression .

 1 The Natural History of Asthma 3 Elizabeth Sapey and Duncan Wilson

 2 Bronchial Challenge Testing 19 Lutz Beckert and Kate Jones

 3 Determination of Biomarkers in Exhaled Breath Condensate: A Perspective Way in Bronchial Asthma Diagnostics 37 Kamila Syslová, Petr Kačer, Marek Kuzma, Petr Novotný and Daniela Pelclová

Part 2 of the Textbook : Immunological Mechanisms in the Development and Progression of Asthma .

 4 Immune Mechanisms of Childhood Asthma 77 T. Negoro, Y. Yamamoto, S. Shimizu, A. H. Banham, G. Roncador, H. Wakabayashi, T. Osabe, T. Yanai, H. Akiyama, K. Itabashi and Y. Nakano

 5 Allergic Asthma and Aging 89 Gabriele Di Lorenzo, Danilo Di Bona, Simona La Piana, Vito Ditta and Maria Stefania Leto-Barone

 6 Airway Smooth Muscle: Is There a Phenotype Associated with Asthma? 117 Gautam Damera and Reynold A. Panettieri, Jr.

 7 Fluoride and Bronchial Smooth Muscle 139 Fedoua Gandia, Sonia Rouatbi, Badreddine Sriha and Zouhair Tabka

Part 3 of the Textbook : The Management of Asthma – Emerging Treatment Strategies .

 8 Management of Asthma in Children 149 Abdulrahman Al Frayh

 9 Mechanisms of Reduced Glucocorticoid Sensitivity in Bronchial Asthma 193 Yasuhiro Matsumura

 10 Antioxidant Strategies in the Treatment of Bronchial Asthma 217 Martin Joyce-Brady, William W. Cruikshank and Susan R. Doctrow

 11 Rehabilitation and Its Concern 231 Ganesan Kathiresan .

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Published by: Unknown - Monday, May 27, 2013


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