Open Access Medical Books



Edited by Evanthia Diamanti-Kandarakis .

478 pages .
Open Access .

Comprehending endocrine disorders requires a combination of basic knowledge on molecular biology and genetics as well as a good grasp of the clinical aspects. Given the recent advances in these fields, an overview of the latest trends and developments affecting endocrinology is provided.
As one of the most up to date publications on this specialist field, this book is the result of a collaboration between a number of leading researchers and practitioners in the field who are recognized for their work over the years in the field of endocrinology. The book provides and indepth analysis across a range of topics focused on hormonal and metabolic disorders.
The book aims to provide a basic as well as advanced recent trends in endocrine disorders in addition to an analytical focus on those topics less well-studied. Readers will find a large spectrum of endocrinopathise from thyroid carcinogenesis and pituitary adenomas to adrenal tumors and metabolic bone disease. Emphasis has also been focused on more specific issues not yet fully elucidated (e.g. the molecular pathways involved in thyrotropin beta gene regulation or monogenic phosphate balance disorders).
We hope that the scope of this book is not only to answer questions but mainly to stimulate new questions.In sharing the knowledge, of the eminent scientists and clinicians in this book with a broad spectrum of readers,it will spark new interest in the expanding spectrum of endocrine disorders.

Prof. Dr. Evanthia Diamanti-Kandarakis
University of Athens Medical School, Sotiria Hospital, Athens,



Part 1 Introduction to Endocrinology .

 1 The Power of an Evolutionary Perspective in Studies of Endocrinology 3 Jing He, David M. Irwin and Ya-Ping Zhang

Part 2 Pituitary Adenomas .

 2 The Genetics of Pituitary Adenomas 25 Monica Fedele, Giovanna Maria Pierantoni and Alfredo Fusco

 3 Acromegaly and Gigantism 51 Fulya Akin and Emrah Yerlikaya

 4 Effects of Growth Hormone (GH) Overexpression in Signaling Cascades Involved in Promotion of Cell Proliferation and Survival 73 Lorena González, Johanna G. Miquet and Ana I. Sotelo

Part 3 The Thyroid Gland .

 5 Negative Regulation of the Thyrotropin  Gene by Thyroid Hormone 101 Shigekazu Sasaki, Akio Matsushita and Hirotoshi Nakamura

 6 Clinical Management of Thyroid Nodules in the Areas of Various Iodine Supply 139 Dorota Słowińska-Klencka, Bożena Popowicz, Stanisław Sporny and Mariusz Klencki

 7 Clinical Workup of Nodular and Mass Lesions of the Endocrine Organs 165 Xiaoqi Lin and Bing Zhu

 8 Molecular Biology of Thyroid Cancer 189 Giuseppe Viglietto and Carmela De Marco

 9 Diagnosis and Differential Diagnosis of Medullary Thyroid Cancer 235 Antongiulio Faggiano, Valeria Ramundo, Gaetano Lombardi and Annamaria Colao

 10 Molecular Diagnostics in Treatment of Medullary Thyroid Carcinoma 251 Brigitte M. Pützer, Alf Spitschak and David Engelmann

 11 Medullary Thyroid Carcinoma Associated with RET Mutations Located in Exon 8 271 Melpomeni Peppa and Sotirios A. Raptis

 12 Status for Congenital Hypothyroidism at Advanced Ages 281 Sevil Ari Yuca

Part 4 Adrenal Glands .

 13 Adrenal Incidentaloma and Adrenocortical Carcinoma: A Clinical Guideline on Treating the Unexpected and a Plea for Specialized Care 291 S.H.A. Brouns, T.M.A. Kerkhofs, I.G.C. Hermsen and H.R. Haak

 14 Adrenal Cortex Tumors and Hyperplasias 311 Duarte Pignatelli

 15 Autoimmunity to Steroid-Producing Cells 355 Alberto Falorni and Stefania Marzotti

16 Excretion of Steroid Hormones in Rodents: An Overview on Species Differences for New Biomedical Animal Research Models 375 Juan Manuel Busso and Rubén Daniel Ruiz

Part 5 Metabolic Bone Disease .

 17 New Trends in Calcium and Phosphorus Metabolism Disorders – Hypoparathyroidism 399 Gonzalo Díaz-Soto and Manuel Puig-Domingo

 18 Monogenic Phosphate Balance Disorders 415 Helge Raeder, Silje Rafaelsen and Robert Bjerknes

 19 Pseudohypoparathyroidism in Children 433 Benjamin U. Nwosu

 20 Retinoids and Bone 443 H. Herschel Conaway and Ulf H. Lerner

 21 Environmental Endocrinology: Endocrine Disruptors and Endocrinopathies 455 Eleni Palioura, Eleni Kandaraki and Evanthia Diamanti-Kandarakis

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Published by: Unknown - Thursday, May 2, 2013


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