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TEXTBOOK : HUMAN PAPILLOMAVIRUS AND RELATED DISEASES – FROM BENCH TO BEDSIDE A DIAGNOSTIC AND PREVENTIVE PERSPECTIVE

HUMAN PAPILLOMAVIRUS

Edited by Davy Vanden Broeck .

334 pages . 
Open Access .


Cervical cancer is the second most prevalent cancer among women worldwide, mainly affecting young women. Infection with Human Papilloma Virus (HPV) has been identified as the causal agent for this condition. The natural history of cervical cancer is characterized by slow disease progression, generally taking over 10 years from the initial infection with HPV till cancer. In essence, cervical cancer is a preventable disease, and treatable if diagnosed in early stage. Historically, the introduction of the Pap smear has markedly reduced the number of new cases countries with an effective prevention program. The burden of disease is highest in developing countries, with peak incidence in Eastern Africa. Recently, prophylactic vaccines became available, equally contributing to a better disease prevention. Unfortunately, the global burden of disease is still very high In the first section, diagnostic and preventive aspects of HPV related diseases are highlighted.
The first two chapters describe in detail molecular approaches in HPV detection. With the introduction of the vaccine, novel challenges arose, Dr. Rodriguez-Iglesias highlights the need for differential screening strategies in the post-vaccine era. Prognosis towards progression of lesions has for many years been an important challenge, and Dr. Hilfrich describes how the L1 protein can be instrumental in disease prediction. In the following chapter, ancillary techniques in the histopathologic diagnosis of squamous or glandural lesions are discussed.
Dr. Mueller contributed a holistic chapter on HPV prevention.
The second section focusses on updated clinical aspects of HPV infections, including general clinical manifestations of HPV infections, penile cancers, head and neck tumors. Dr. Trottier describes the epidemiology of anogenital HPV infections, and dr. Duerksen-Hughes provided an overview of modern molecular approaches to eradicate HPV induced cervical cancer.
The last chapter provides insights in the analysis of the native virus.
This book will be a useful tool for both researchers and clinicians dealing with cervical cancer, and will provide them with the latest information in this field.

Prof. Dr. Davy Vanden Broeck, MSc, PhD.
Team leader HPV/cervical cancer research
International Centre for Reproductive Health
Ghent University
Belgium

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CONTENTS : 


Section 1 Diagnostic and Preventive Aspects of HPV-Related Diseases .


 1 Molecular Diagnosis of Human Papillomavirus Infections 3 Santiago Melón, Marta Alvarez-Argüelles and María de Oña

 2 Molecular Tools for Detection Human Papillomavirus 27 Angela Adamski da Silva Reis, Daniela de Melo e Silva, Cláudio Carlos da Silva and Aparecido Divino da Cruz

 3 HPV Diagnosis in Vaccination Era 57 Fátima Galán-Sánchez and Manuel Rodríguez-Iglesias

 4 HPV L1 Detection as a Prognostic Marker for Management of HPV High Risk Positive Abnormal Pap Smears 93 Ralf Hilfrich

5 Ancillary Techniques in the Histopathologic Diagnosis of Squamous and Glandular Intraepithelial Lesions of the Uterine Cervix 117 Evanthia Kostopoulou and George Koukoulis

 6 Human Papillomavirus Prophylactic Vaccines and Alternative Strategies for Prevention 149 Lis Ribeiro-Müller, Hanna Seitz and Martin Müller

Section 2 Clinical Aspects of HPV-Infections .


 7 Clinical Manifestations of the Human Papillomavirus 187 Miguel Ángel Arrabal-Polo, María Sierra Girón-Prieto, Jacinto Orgaz-Molina, Sergio Merino-Salas, Fernando Lopez-Carmona Pintado, Miguel Arrabal-Martin and Salvador Arias-Santiago

 8 Human Papillomavirus Infection and Penile Cancer: Past, Present and Future 221 João Paulo Oliveira-Costa, Giórgia Gobbi da Silveira, Danilo Figueiredo Soave, Andrielle de Castilho Fernandes, Lucinei Roberto Oliveira, Alfredo Ribeiro-Silva and Fernando Augusto Soares

 9 The Role of Human Papillomavirus in Pre-Cancerous Lesions and Oral Cancers 241 Danilo Figueiredo Soave, Mara Rubia Nunes Celes, João Paulo Oliveira-Costa, Giorgia Gobbi da Silveira, Bruna Riedo Zanetti, Lucinei Roberto Oliveira and Alfredo Ribeiro-Silva

 10 Epidemiology of Anogenital Human Papillomavirus Infections 269 Claudie Laprise and Helen Trottier

 11 Modern Molecular and Clinical Approaches to Eradicate HPVMediated Cervical Cancer 287
Whitney Evans, Maria Filippova, Ron Swensen and Penelope Duerksen-Hughes




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