Open Access Medical Books



Edited by Elvis Malcolm Irusen .

702 pages .
Open Access .

The developments in molecular medicine are leading to important insights with regard to lung diseases. Leading clinicians and scientists in the world have brought their considerable knowledge and experience, and focused research in their contributions to this book. Clinicians and researchers will learn about the most recent advances in a variety of lung diseases that will enable them to better understand respiratory disorders. The book presents state-of-the-art essays on airways disease, neoplastic diseases, and pediatric respiratory conditions. Additionally, aspects of immune regulation, respiratory infections, acute lung injury/ ARDS, pulmonary oedema, functional evaluation in respiratory disorders, and a variety of other conditions are also expounded upon. The compilation and availability of the book online has also ensured that information is as current as possible, which is an advantage over the printed editions.
The book will be invaluable for clinicians who appreciate the pathogenetic basis and current concepts in lung diseases and improve their diagnostic and therapeutic skills.
Scientists will also gain something from the detailed applied molecular techniques and descriptions that could potentially open a plethora of new research avenues for exploration.

Professor E.M. Irusen
Department of Medicine,
Faculty of Health Sciences,
University of Stellenbosch,
Western Cape Province,
South Africa


Part 1 Airways Disease .

 1 Airway Smooth Muscle in Asthma Symptoms: Culprit but Maybe Innocent 3 Ynuk Bossé, Peter D. Paré and Yohan Boss

 2 Polymerization and Oxidation of Alpha-1-Antitrypsin in Pathogenesis of Emphysema 55 Aleksandra Topic and Dragica Radojkovic

 3 Recent Advances in the Research and Development of Alpha-1 Proteinase Inhibitor for Therapeutic Use 83 Elena Karnaukhova

 4 Mechanisms Promoting Chronic Lung Diseases: Will Targeting Stromal Cells Cure COPD and IPF? 105 Lynne A. Murray and Cory M. Hogaboam

Part 2 Neoplasia .

 5 Cancer Stem Cells (CSCs) in Lung Cancer 129 Hiroyuki Sakashita, Yuki Sumi and Naohiko Inase

 6 Oncogenes and Tumor Suppressor Genes in Small Cell Lung Carcinoma 147 Pankaj Taneja, Robert D. Kendig, Sinan Zhu, Dejan Maglic, Elizabeth A. Fry and Kazushi Inoue

 7 Centrosome Abnormality and Human Lung Cancer 171 Kazuya Shinmura and Haruhiko Sugimura

 8 Defective Expression and DNA Variants of TGFBR2 in Chinese Small Cell Lung Carcinoma 189 ZhenHong Zhao, Jibin Xu, Jun Xie, Yang Bao, Xiaotian Wang, Lei Wang, Junjie Wu, Li Jin, Zhiyun Xu and Jiucun Wang

 9 Neuroendocrine Tumours of the Lung 203 Guadalupe Aparicio Gallego, Vanessa Medina Villaamil, Ana Capdevila Puerta, Enrique Grande Pulido and L.M. Antón Aparicio

 10 Chemotherapy for Large Cell Neuroendocrine Carcinoma of the Lung: Should It Be Treated with the Same Strategy as Small Cell Lung Carcinoma? 231 Katsuhiko Naoki, Kenzo Soejima, Takashi Sato, Shinnosuke Ikemura, Hideki Terai, Ryosuke Satomi, Sohei Nakayama, Satoshi Yoda and Koichiro Asano

 11 Radiation Therapy in Management of Small-Cell Lung Cancer 239 Erkan Topkan and Cem Parlak

 12 Lung Parenchyma Sparing Resection for Pulmonary Malignancies 257 Arpad Pereszlenyi

 13 Surgery in Small-Cell Lung Cancer: Past, Present and Future 275 Cristian Rapicetta, Sara Tenconi, Tommaso Ricchetti, Sally Maramotti and Massimiliano Paci

Part 3 Immunity and Infection .

 14 Interleukin-17 and T Helper 17 Cells in Mucosal Immunity of the Lung 299 M.S. Paats, P.Th.W. van Hal, C.C. Baan, H.C. Hoogsteden, M.M. van der Eerden and R.W. Hendriks

 15 Current Status of the Mollicute (Mycoplasma) Lung Disease: Pathogenesis, Diagnostics, Treatment and Prevention 331 Silvia Giono-Cerezo, Guadalupe Estrada-Gutiérrez, José Antonio Rivera-Tapia, Jorge Antonio Yáñez-Santos and Francisco Javier Díaz-García

 16 Pulmonary Paracoccidioidomycosis: Clinical, Immunological and Histopathological Aspects 359 Luz E. Cano, Ángel González, Damaris Lopera, Tonny W. Naranjo and Ángela Restrepo

 17 Nocardia Infection in Lung Transplantation 393 Pilar Morales, Ana Gil-Brusola and María Santos

 18 In Vivo Models of Lung Disease 407 Tracey L. Bonfield

 19 Inhibition of Adhesion and Invasion of Pseudomonas aeruginosa to Lung Epithelial Cells: A Model of Cystic Fibrosis Infection 429 Ayman M. Noreddin, Ghada Sawy, Walid Elkhatib, Ehab Noreddin and Atef Shibl

Part 4 Paediatrics .

 20 Bronchitis in Children 443 Christian Peiser

 21 Bronchopulmonary Dysplasia 463 Shou-Yien Wu, Sachin Gupta, Chung-Ming Chen and Tsu-Fuh Yeh

 22 Bronchopulmonary Dysplasia: The Role of Oxidative Stress 485 Jean-Claude Lavoie and Ibrahim Mohamed

 23 Partial Liquid Ventilation in the Extremely Preterm Infant: Potential Benefits and Harms 505 Mark William Davies

Part 5 Pulmonary Oedema: Cardiogenic and Non-Cardiogenic .

 24 Non-Cardiogenic Pulmonary Edema 525 J. Gonzales and A. Verin

 25 High Altitude Pulmonary Edema 539 Zhou Qiquan and Luo Yongjun

 26 Mechanical Forces Impair Alveolar Ion Transport Processes – A Putative Mechanism Contributing to the Formation of Pulmonary Edema 561 Martin Fronius

Part 6 Miscellaneous .

 27 Functional Evaluation in Respiratory Disorders 581 Cirelene Grobler, David M. Maree and Elvis M. Irusen

 28 Novel Methods for Diagnosis of Pulmonary Microangiopathy in Diabetes Mellitus 603 Kalicka Renata and Kuziemski Krzysztof

 29 The Pneumoconioses 625 Nlandu Roger Ngatu, Ntumba Jean-Marie Kayembe, Benjamin Longo-Mbenza and Narufumi Suganuma

 30 Lung Transplantation: Advances and Roadblocks in Treatment 647 Matthew T. Hardison and J. Edwin Blalock

 31 Bronchial Atresia 671 Lirios Sacristán Bou and Francisco Peña Blas

 32 A Case of Adult Congenital Cystic Adenomatoid Malformation of the Lung with Atypical Adenomatous Hyperplasia 685 Ho Sung Lee, Jae Sung Choi, Ki Hyun Seo, Ju Ock Na, Yong Hoon Kim, Mi Hye Oh and Sung Shick Jou

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Published by: Unknown - Sunday, May 26, 2013


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