Open Access Medical Books



Edited by Colleen Croniger .

Open Access .
422 pages .

Obesity and type 2 diabetes are increasing worldwide problems. In this book we reviewed insulin secretion in both healthy individuals and in patients with type 2 diabetes. Because of the risk associated with progression from insulin resistance to diabetes and cardiovascular complications increases along a continuum, we included several chapters on the damage of endothelial cells in type 2 diabetes and genetic influences on endothelial cell dysfunction. Cardiovascular complications occur at a much lower glucose levels, thus a review on the oral glucose tolerance test compared to other methods was included. The medical conditions associated with type 2 diabetes such as pancreatic cancer, sarcopenia and sleep disordered breathing with diabetes were also discussed. The book concludes with several chapters on the treatments for this disease offering us hope in prevention and successful alleviation of the co-morbidities associated with obesity and type 2 diabetes.

Colleen Croniger
Department of Nutrition, Case Western Reserve University,
School of Medicine, Cleveland,Ohio



Part 1 Insulin Resistance .

 1 Insulin Secretion and Actions 3 Sarawut Jitrapakdee and Briony E. Forbes

 2 The Oral Glucose Tolerance Test: An Old but Irreplaceable Test to Evaluate Glucose Metabolism and Cardiovascular Risk 27 Gian Paolo Fra, Ettore Bartoli and Gian Piero Carnevale Schianca

 3 The Role of Parathyroid Hormone-Related Protein (PTHRP) in the Pathophysiology of Diabetes Mellitus 39 Ioannis Legakis

 4 Impaired Vascular BK Channel Function in Type 2 Diabetes Mellitus 53 Tong Lu and Hon-Chi Lee

Part 2 Endothelial Cells and Type 2 Diabetes .

 5 Endothelial Progenitor Cell Dysfunction in Diabetes Mellitus Type-2: Focus on Nitric Oxide System 73 Saher Hamed

 6 Glycaemic Control and Protection of the Vasculature from Glucose Toxicity 87 Hong Ding and Chris R. Triggle

 7 Endothelial Dysfunction and Therapeutic Intervention in Type 2 Diabetes 111 Fernando Grover Páez

Part 3 Genetics of Type 2 Diabetes .

 8 Using Gene Expression Signatures to Dissect Insulin Resistance Subtypes 145 Brad Hayward, Nicky Konstantopoulos and Ken R. Walder

 9 The Role of Single Nucleotide Polymorphisms of Untranslated Regions (Utrs) in Insulin Resistance Pathogenesis in Patients with Type 2 Diabetes 165 Małgorzata Małodobra

 10 Genetics of Endothelial Damage Associated to Diabetes Mellitus Type 2 189 Lorena García, Carlos Wolff, Verónica Araya, Gloria López, Sergio Lobos, Pilar Durruty and Daniela Seelenfreund

 11 Functional Context Network of T2DM 213 Anja Thormann and Axel Rasche

Part 4 Complications of Type 2 Diabetes .

 12 Sarcopenia, Sarcopenic Obesity and Insulin Resistance 233 John A. Batsis and Silvio Buscemi

 13 Type 2 Diabetes and Pancreatic Cancer – A Possible Reason 257 Parviz M Pour

14 Pathophysiology in Type 2 Diabetes – Type 2 Diabetes and Sleep-Disordered Breathing/Sleep Apnea – Role of Adipocytokines 267 Ken Kishida

Part 5 Treatments and Therapy .

 15 Can Bariatric or Metabolic Surgery Cure Type 2 Diabetes? 279 Gustavo P. S. Miguel, Perseu Carvalho, João Luiz Azevedo, Murilo Hosken Júnior, Évelyn Zambrana, Otávio Azevedo and Isaac Abreu

 16 Nuclear Imaging of Glucose Transport/Metabolism – An Interesting Tool to Screen Insulin Resistance, Refine Diagnosis of Type 2 Diabetes, Understand Disease Mechanisms, and/or Evaluate New Therapies 291 P. Perret, M. Henri, L. Slimani, D.Fagret and C. Ghezzi

 17 Targeting PKA Signaling to Prevent Metabolic Syndrome and Delay Aging 303 Linda C Enns and Warren C Ladiges

 18 Targeting AMPK for Therapeutic Intervention in Type 2 Diabetes 321 Mohamed Kodiha and Ursula Stochaj

 19 Design and Evaluation of a Complex Phytoceutical Formulation for Circulatory Diseases 349 J. Olalde, A. Antoshechkin, O. del Castillo, R. Guzmán and F. Améndola

 20 Effectiveness of Fenugreek for Lowering Hemoglobin (HbA1c) in Patients with Self-Management of Type 2 Diabetes: A Randomized Controlled Trial 393 Rashid Ansari and Saiqaa Ansari

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Published by: Unknown - Thursday, May 2, 2013


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