Open Access Medical Books



Edited by Clark Chen .

672 pages .
Open Access .

DNA repair processes are of fundamental importance to all aspects of cell biology. It is through these processes and their critical interfaces to DNA replication, transcription, cell cycle, telomere maintenance, and other essential cellular processes that genomic stability is maintained. The aims of this edition are three-fold. The first section of the book aims to illustrate novel mechanistic insights into the various forms of DNA repair. The second section of the book describes works that elucidate the interfaces between DNA repair and the various essential processes. The final section of the book outlines strategies for clinical translation of the vast reservoir of knowledge on this topic into therapeutic, prognostic, and predictive platforms.

Clark C. Chen, M.D., Ph.D.
University of California, San Diego



Section 1 Novel Insights into DNA Repair .

 1 Recombination Hot-Spots and Defense Players – Maintenance of Genomic Integrity 3 Radhika Pankaj Kamdar and Basuthkar J. Rao

 2 The Role of Multimerization During Non-Homologous End Joining 41 Michelle Rubin, Jonathan Newsome and Albert Ribes-Zamora

 3 Epimutation in DNA Mismatch Repair (MMR) Genes 67 Kouji Banno, Iori Kisu, Megumi Yanokura, Yuya Nogami, Kiyoko Umene, Kosuke Tsuji, Kenta Masuda, Arisa Ueki, Nobuyuki Susumu and Daisuke Aoki

 4 Evolving DNA Repair Polymerases: From Double—Strand Break Repair to Base Excision Repair and VDJ Recombination 85 Maria Jose Martin and Luis Blanco

 5 Direct Repair in Mammalian Cells 123 Stephanie L. Nay and Timothy R. O‘Connor

 6 Chromatin Remodeling in Nucleotide Excision Repair in Mammalian Cells 163 Wilner Martínez-López, Leticia Méndez-Acuña, Verónica Bervejillo, Jonatan Valencia-Payan and Dayana Moreno-Ortega

 7 Emerging Features of DNA Double-Strand Break Repair in Humans 187 Hyun Suk Kim, Robert Hromas and Suk-Hee Lee

 8 Regulation of DNA Repair Process by the Pro-Inflammatory NF-κB Pathway 213 Simarna Kaur, Thierry Oddos, Samantha Tucker-Samaras and Michael D. Southall

Section 2 Interface with DNA Replication, Transcription, Telomeres, and Cell Cycle Regulation .

 9 Relation of the Types of DNA Damage to Replication Stress and the Induction of Premature Chromosome Condensation 231 Dorota Rybaczek and Magdalena Kowalewicz-Kulbat

 10 p21CDKN1A and DNA Repair Systems: Recent Findings and Future Perspectives 249 Micol Tillhon, Ornella Cazzalini, Ilaria Dutto, Lucia A. Stivala and Ennio Prosperi

 11 The Role of P53 Exonuclease in Accuracy of DNA Synthesis and Sensitivity to Nucleoside Analogs in Various Compartments of Cells 281 Galia Rahav and Mary Bakhanashvili

 12 Biological Systems that Control Transcription of DNA Repair and Telomere Maintenance-Associated Genes 309 Fumiaki Uchiumi, Steven Larsen and Sei-ichi Tanuma

 13 The Endothelin Axis in DNA Damage and Repair: The Cancer Paradigm 327 Panagiotis J. Vlachostergios and Christos N. Papandreou

 14 DNA Repair and Telomeres — An Intriguing Relationship 339 Effrossyni Boutou, Dimitris Vlachodimitropoulos, Vassiliki Pappa, Horst-Werner Stürzbecher and Constantinos E. Vorgias

Section 3 Interface with Clinical Medicine .

 15 Genetic Polymorphisms of DNA Repair Genes and DNA Repair Capacity Related to Aflatoxin B1 (AFB1)-Induced DNA Damages 377 Qiang Xia, Xiao-Ying Huang, Feng Xue, Jian-Jun Zhang, Bo Zhai, De- Chun Kong, Chao Wang, Zhao-Quan Huang and Xi-Dai Long

 16 DNA Damage, DNA Repair and Cancer 413 Carol Bernstein, Anil R. Prasad, Valentine Nfonsam and Harris Bernstein

 17 New Potential Therapeutic Approaches by Targeting Rad51- Dependent Homologous Recombination 467 Axelle Renodon-Cornière, Pierre Weigel, Magali Le Breton and Fabrice Fleury

 18 DNA Repair and Resistance to Cancer Therapy 489 António S. Rodrigues, Bruno Costa Gomes, Célia Martins, Marta Gromicho, Nuno G. Oliveira, Patrícia S. Guerreiro and José Rueff

 19 DNA Base Excision Repair: Evolving Biomarkers for Personalized Therapies in Cancer 529 Vivek Mohan and Srinivasan Madhusudan

 20 Nucleotide Excision Repair Inhibitors: Still a Long Way to Go 559 K. Barakat and J. Tuszynski

 21 The Molecular Epidemiology of DNA Repair Polymorphisms in Carcinogenesis 579 Paul W. Brandt-Rauf, Yongliang Li, Changmin Long and Regina Monaco

 22 Aspects of DNA Damage from Internal Radionuclides 597 Christopher Busby

 23 Radiosensitization Strategies Through Modification of DNA Double-Strand Break Repair 639 Yoshihisa Matsumoto, Shoji Imamichi, Mikoto Fukuchi, Sicheng Liu, Wanotayan Rujira, Shingo Kuniyoshi, Kazuki Yoshida, Yasuhiro Mae and Mukesh Kumar Sharma

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Published by: Unknown - Thursday, May 23, 2013


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