Open Access Medical Books



Edited by Umashankar Lakshmanadoss .

Open Access .
468 pages .

Ischemic heart disease continues to be the leading cause of morbidity and mortality in both developed and developing countries, and remains one of the most important public health problems. The continuous rise in the prevalence of disorders such as obesity, diabetes, dyslipidemia and hypertension is driving the ever-increasing number of incidences of ischemic heart disease. In recent years we have seen remarkable advances in the understanding of ischemic heart disease in areas such as epidemiology, risk assessment, risk factor reduction, pathophysiology, early detection, biochemical markers, imaging and in treatments. Nevertheless, the importance of prevention and personal responsibility in controlling the disease has also attracted great attention. As we all know, cardiovascular medicine is an ever-growing field; ongoing research has led to new discoveries in management, leading to improvements in the outcomes of the patients with cardiovascular diseases.
The first edition of this book will provide a comprehensive overview of ischemic heart disease, including epidemiology, risk factors, pathogenesis, clinical presentation, diagnostic tests, differential diagnosis, treatment, complications and prognosis. Also discussed are current treatment options, protocols and diagnostic procedures, as well as the latest advances in the field. The book will serve as a cutting-edge point of reference for the basic or clinical researcher, and any clinician involved in the diagnosis and management of ischemic heart disease. This book is essentially designed to fill the vital gap existing between these practices to provide a textbook that is substantial and readable, compact and reasonably comprehensive, and to provide an excellent blend of “basics to bedside and beyond” in the field of ischemic heart disease.
With increasing life expectancy and increasing prevalence of the disease, patients with ischemic heart disease are being taken care of by various health care providers. I sincerely hope that this textbook will meet the needs of nurses, healthcare providers, medical students, clinicians, physician scientists and, of course, patients. With this information easily accessible via the internet, no one is deprived of the pioneering technology and ongoing research. I am thrilled to present the various chapters like epidemiology, diagnosis of ischemic heart disease and its complications, management of ischemic heart disease and its risk factors and complications. Chapters discussing translational research and novel treatment strategies will be really exciting for those interested in basic science research.

I gratefully acknowledge the invaluable organisational skills of the publisher InTech, the timely and invaluable assistance of publishing process manager Ms Maja Bozicevic, designer, technical editors, information technology staff and finally the marketing representatives who are working constantly to promote the book on various platforms. I sincerely applaud all the contributing authors for their excellence, hard work and commitment in respect of their chapters. They have taken time from their personal and professional lives to complete this task and I thank them profusely for it.
I believe that this book will provide valuable information for all healthcare providers who are trying to make a positive difference in our fellow human beings' lives. 
Let's love humanity through love of our profession.

Umashankar Lakshmanadoss MD
Formerly Director, Inpatient Medicine Consult Service,
JHBMC, Johns Hopkins University School of Medicine,
Baltimore, MD,
Division of Cardiology, Guthrie Clinic,
Sayre, PA,



Part 1 Introduction .

 1 Overview of Coronary Artery Disease 3 Umashankar Lakshmanadoss

Part 2 Diagnostics of Ischemic Heart Disease .

 2 Cardiac Biomarkers 17 Sadip Pant, Abhishek Deshmukh, Pritam Neupane, M.P. Kavin Kumar and C.S. Vijayashankar

 3 Inflammatory Biomarkers in Ischemic Heart Disease 43 Mette Bjerre

 4 Measurement of Myocardial Contractility in the Ischemic Heart – A Disease Immanent Uncertainty 63 Jens Broscheit

 5 Electrical Heart Instability Evaluation in Conditions of Diastolic Heart Failure Suffered by Coronary Heart Disease Patients 81 E.P. Tatarchenko, N.V. Pozdnyakova, O.E. Morozova and E.A. Petrushin

Part 3 Pharmacotherapy of Ischemic Heart Disease .

 6 Prehospital Thrombolysis: It’s All About Time 101 Raveen Naidoo and Nicholas Castle

 7 Thrombolysis in Myocardial Infarction 123 Ajay Suri, Sophia Tincey, Syed Ahsan and Pascal Meier

 8 Platelet Activation in Ischemic Heart Disease: Role of Modulators and New Therapies 135 Mahdi Garelnabi, Javier E. Horta and Emir Veledar

 9 Myocardial Ischemia-Reperfusion/Injury 163 Nermine Saleh and Magda Youssef

Part 4 Novel Treatment Strategies .

 10 Connexin 43 Hemichannels and Pharmacotherapy of Myocardial Ischemia Injury 189 Ghayda Hawat and Ghayath Baroudi

 11 Myocardial Ischemia: Alterations in Myocardial Cellular Energy and Diastolic Function, a Potential Role for D-Ribose 219 Linda M. Shecterle and J. A. St. Cyr

 12 Two Novel Approaches Providing Cardiac Protection Against Oxidative Stress 229 Howard Prentice and Herbert Weissbach

 13 Hepatic Lipid Accumulation by High Cholesterol Diet is Inhibited by the Low Dose Fish Oil in Male C57BL/6J Mice 247 Satoshi Hirako, Miki Harada, Hyoun-Ju Kim, Hiroshige Chiba and Akiyo Matsumoto

 14 Cardiac Protection with Targeted Drug Delivery to Ischemic-Reperfused Myocardium 253 Michael Galagudza

 15 Topical Negative Pressure, Applied onto the Myocardium, a Potential Alternative Treatment for Patients with Coronary Artery Disease in the Future 275 Sandra Lindstedt, Malin Malmsj√∂, Joanna Hlebowicz and Richard Ingemansson

 16 Ischemic Heart Disease, Diabetes and Mineralocorticoid Receptors 287 Anastasia Susie Mihailidou

Part 5 Public Health Importance of Ischemic Heart Disease . 

 17 Cardiology Best Practice – Effective Health Education Meets Biomedical Advances: Reducing the Ultimate Knowledge Translation Gap 301 Elizabeth Dean, Zhenyi Li, Wai Pong Wong and Michael E. Bodner

 18 Inpatient Costs Associated with Ischemic Heart Disease Among Adults Aged 18-64 Years in the United States 319 Guijing Wang, Zefeng Zhang, Carma Ayala, Diane Dunet and Jing Fang

 19 Post-Myocardial Infarction Depression 333 Rousseau Guy, Thierno Madjou Bah and Roger Godbout

 20 Cytochrome P450 Epoxygenase CYP2J2 G-50T Polymorphism is an Independent Genetic Prognostic Risk Factor and Interacts with Smoking Cessation After Index Premature Myocardial Infarction 363 Ping-Yen Liu, Yi-Heng Li and Jyh-Hong Chen

Part 6 Miscellaneous .

 21 Coronary Artery Aneurysms: An Update 381 Karina M. Mata, Cleverson R. Fernandes, Elaine M. Floriano, Antonio P. Martins, Marcos A. Rossi and Simone G. Ramos

 22 Cardiac Function and Organ Blood Flow at Early Stage Following Severe Burn 405 Rong Xiao and Yue-Sheng Huang

 23 Aging, Reactive Nitrogen Species and Myocardial Apoptosis Induced by Ischemia/Reperfusion Injury 429 Huirong Liu, Ke Wang, Xiaoliang Wang, Jue Tian, Jianqin Jiao, Kehua Bai, Jie Yang and Haibo Xu

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Published by: Unknown - Friday, May 17, 2013


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