Open Access Medical Books

TEXTBOOK : PROGRESS IN HEMODIALYSIS – FROM EMERGENT BIOTECHNOLOGY TO CLINICAL PRACTICE


HEMODIALYSIS

Edited by Angelo Carpi, Carlo Donadio and Gianfranco Tramonti.

Open Access .
456 pages .


Hemodialysis (HD) represents the first successful long term substitutive therapy with an artificial organ for severe failure of a vital organ. Because HD was started many decades ago, a book on HD may not appear up-to-date.
Indeed, HD covers many basic and clinical aspects and this book reflects the rapid expansion of new and controversial aspects either in the biotechnological or in the clinical field.
The related topics are multiple because HD includes either biotechnology or multiorgan involvement as well as different pathogenetic factors. Many efforts to reduce dialysis complications and their treatment are made. This book revises new technologies and therapeutic options to improve dialysis treatment of uremic patients.
This book consists of three parts:
 modeling, methods and technique
 prognosis
 complications
The first part includes twelve chapters, five on modeling, water and electrolyte preparation or regulation, four face membranes and biocompatibility, the remaining three deal with procedures or controversies.
Besides important progress in biotechnology, a common and principal aim crossing most of these chapters is the attempt to reduce morbidity by the use of more compatible devices. Prediction of morbidity or mortality by progress in the laboratory is a principal general topic or aim of the second group of four chapters. These chapters underline the relevance of the residual renal function and of the main laboratory biomarkers to predict cardiovascular complications.
The third part includes seven chapters on clinical complications. The principal topic crossing two chapters is the importance of metabolic disorders for the origin and the development of the most important clinical complications (cardiovascular and bone).

The remaining five chapters deal with lifestyle aspects (sleep or physical activity) and local (vascular access) or systemic (infections) complications.
Therefore, this book reflects either emergent biotechnological or updated clinical aspects concerning HD. These two topics include suggestions to improve prognosis and therapy of the patients on HD. The book will help not only general physicians, nephrologists, internists, cardiologists, endocrinologists but also basic researchers, including bioengineers, to approach, understand and manage the principal problems related to HD.
Finally, we consider that we were medical students in the same university hospital in the sixties and successively we worked in the same university hospital department. Our original department of internal medicine specialized in nephrology, under the leadership of the late Prof. Gabriele Monasterio, who first proposed and validated the low protein diet and included teachers who were pioneers in projecting and using the artificial kidney.
Thanks to them, the authors of these book chapters and the publisher, we once more have the pleasure to work together in this project including colleagues from multiple continents.

Prof. Angelo Carpi, M.D.,
Department of Reproduction and Aging, University of Pisa,
Italy

Prof. Carlo Donadio, M.D.,
Department of Internal Medicine, University of Pisa,
Italy

Prof. Gianfranco Tramonti, M.D.,
Department of Internal Medicine, University of Pisa,
Italy



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CONTENTS :



Part 1 Modeling, Methods and Technique of Hemodialysis .


 1 Kinetic Modeling and Adequacy of Dialysis 3 Malgorzata Debowska, Bengt Lindholm and Jacek Waniewski

 2 Automated Blood VolumeRegulation During Hemodialysis 27 Isabelle Chapdelaine, Clément Déziel and François Madore

 3 Sodium and Hemodialysis 47 Matthew Gembala and Satish Kumar

 4 Polyethersulfone Hollow Fiber Membranes for Hemodialysis 65 Baihai Su, Shudong Sun and Changsheng Zhao

 5 The Evolution of Biocompatibility: From Microinflammation to Microvesiscles 93 Ciro Tetta, Stefano Maffei, Barbara Cisterna, Valentina Fonsato, Giorgio Triolo, Giuseppe Paolo Segoloni, Giovanni Camussi, Maria Chiara Deregibus and Emanuele Gatti

 6 Pulse Push/Pull Hemodialysis: Convective Renal Replacement Therapy 113 Kyungsoo Lee

 7 Optical Dialysis Adequacy Monitoring: Small Uremic Toxins and Contribution to UV-Absorbance Studied by HPLC 143 Kai Lauri, Jürgen Arund, Jana Holmar, Risto Tanner, Merike Luman and Ivo Fridolin

 8 Influence of Online Hemodiafiltration on Hemoglobin Level, ESA-Dosage and Serum Albumin – A Retrospective, Multicenter Analysis 161 Roland E. Winkler, Peter Ahrenholz and Klaus Freivogel

 9 Leukocyte Function in High-Flux Hemodialysis 175 Jenny Olsson

 10 Dialysis Membrane Manipulation for Endotoxin Removal 197 Michael Henrie, Cheryl Ford, Eric Stroup and Chih-Hu Ho

 11 Citrate Anticoagulation in Hemodialysis 217 Stephan Thijssen

 12 Hemodialysis Principles and Controversies 227 Parin Makadia, Payam Benson, Filberto Kelly and Joshua Kaplan

Part 2 Prognosis for Hemdialysis Patients  .


 13 Residual Renal Function in Hemodialysis Patients 255 Zachary Z. Brener, Stephan Thijssen, Peter Kotanko, James F. Winchester and Michael Bergman

 14 Biomarkers in Chronic Kidney Disease - The Linkage Between Inflammation, Ventricular Dysfunction and Overhydration 265 Olimpia Ortega

 15 Determinants of Cardiovascular Risk in Hemodialysis Patients Without Significant Comorbidities 281 Aysegul Zumrutdal

 16 Malnutrition, Inflammation and Reverse Epidemiology in Hemodialysis Patients 297 Rodney G. Bowden, Neil A. Schwarz and Brian D. Shelmadine

Part 3 Hemdialysis Complications .


 17 Complications and Managements of Hyperphosphatemia in Dialysis 315 Eiji Takeda, Hironori Yamamoto, Hisami Yamanaka-Okumura and Yutaka Taketani

 18 Management of Secondary Hyperparathyroidism in Hemodialysis Patients 331 Emanuel Zitt and Ulrich Neyer

 19 Lipid and Lipoprotein Abnormalities in Chronic Renal Insufficiency: Review 349 Oliver Rácz, Rudolf Gaško and Eleonóra Klímová

 20 Hemodialysis Vascular Access Dysfunction 365 Timmy Lee

 21 Nontraditional Anti - Infectious Agents in Hemodialysis 389 Martin Sedlacek

 22 Sleep in Patients with ESRD Undergoing Hemodialysis 407 Mukadder Mollaoğlu

 23 The Importance of Exercise Programs in Haemodialysis Patients 429 Susanne Heiwe, Andrej Ekholm and Ingela Fehrman-Ekholm





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