Open Access Medical Books

TEXTBOOK : ROLE OF THE ADIPOCYTE IN DEVELOPMENT OF TYPE 2 DIABETES

Edited by Colleen Croniger .

382 pages . 
Open Access . 


Adipocytes are important in the body for maintaining proper energy balance by storing excess energy as triglycerides. However, efforts of the last decade have identified several molecules that are secreted from adipocytes, such as leptin, which are involved in signaling between tissues and organs. These adipokines are important in overall regulation of energy metabolism and can regulate body composition as well as glucose homeostasis. Excess lipid storage in tissues other than adipose can result in development of diabetes and nonalcoholic fatty liver disease (NAFLD). In this book we review the role of adipocytes in development of insulin resistance, type 2 diabetes and NAFLD. Because type 2 diabetes has been suggested to be a disease of inflammation we included several chapters on the mechanism of inflammation modulating organ injury. Finally, we conclude with a review on exercise and nutrient regulation for the treatment of type 2 diabetes and its co-morbidities.

Colleen Croniger
Department of Nutrition
Case Western Reserve University
School of Medicine
Cleveland,Ohio
USA

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CONTENTS :



Part 1 Adipocyte Function .


 1 The Sick Adipocyte Theory: The Forces of Clustering at Glance 3 Valmore Bermúdez, Joselyn Rojas, Miguel Aguirre, Clímaco Cano, Nailet Arraiz, Carlos Silva Paredes,Marcos Lima, Raquel Cano, Eneida Fonseca and Manuel Velasco

 2 Lipid Droplets and Very Low Density Lipoproteins; Their Relation to Insulin Resistance 29 Sven-Olof Olofsson, Linda Andersson, Jeanna Perman, Mikael Rutberg, Lilliana Håversen, Li Lu, Emma Lu, Reza Mobini, Marcus Ståhlman, Susanna Myhre, Christina Olsson, Rosie Perkins,Thomas Larsson, Jan Borén and Martin Adiels

 3 Role of Triglyceride/Fatty Acid Cycle in Development of Type 2 Diabetes 53 Chang-Wen Hsieh, David DeSantis and Colleen M Croniger

 4 Obesity and Systemic Inflammation: Insights into Epigenetic Mechanisms 65 Perla Kaliman and Marcelina Párrizas

 5 Inflammatory Markers Associated with Chronic Hyperglycemia and Insulin Resistance 89 Denisa Margina

Part 2 Oxidative Stress .


 6 The Regulation of Energy Metabolism Pathways Through L-Carnitine Homeostasis 107 Edgars Liepinsh, Ivars Kalvinsh and Maija Dambrova

 7 Oxidative Stress in Type II Diabetes Mellitus and the Role of the Endogenous Antioxidant Glutathione 129 Stephney Whillier, Philip William Kuchel and Julia Elizabeth Raftos

 8 The Role of Oxidative Stress in Pathogenesis of Diabetic Neuropathy: Erythrocyte Superoxide Dismutase, Catalase and Glutathione Peroxidase Level in Relation to Peripheral Nerve Conduction in Diabetic Neuropathy Patients 153 Gordana M. Djordjević, Stojanka S.Djurić, Vidosava B. Djordjević, Slobodan Apostolski and Miroslava Živković

 9 Interactions Between Total Plasma Homocysteine, Oxidized LDL Levels, Thiolactonase Activities and Dietary Habits in Tunisian Diabetic Patients 179 Nadia Koubaa, Maha Smaoui, Sounira Mehri, Amel Nakbi, Sonia Hammami, Raja Chaaba, Khaldoun Ben Hamda, Fethi Betbout, Mohamed Ameur Frih and Mohamed Hammami

Part 3 Consequences of Obesity .


 10 Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance 197 Po-Shiuan Hsieh

11 Assessment of Abdominal Adiposity and Organ Fat with Magnetic Resonance Imaging 215 Houchun H. Hu, Michael I. Goran and Krishna S. Nayak

 12 Non-Alcoholic Fatty Liver Disease (NAFLD), Adipocytokines and Diabetes Mellitus 241 Dhastagir Sultan Sheriff

 13 Disturbed Chylomicron Metabolism in Type 2 Diabetes - A Preventable Cause of Atherosclerosis? 253 Gerald H. Tomkin and Daphne Owens

 14 The Role of Adipose Tissue in Diabetic Kidney Disease 273 Young Sun Kang, Jin Joo Cha, Young Youl Hyun, Ji Eun Lee, Hyun Wook Kim and Dae Ryong Cha

 15 The Role of the Endocannabinoid System in the Pathogeny of Type 2 Diabetes 289 Robert Dinu, Simona Popa and Maria Mota

Part 4 Treatments .


16 Beyond Dietary Fatty Acids as Energy Source: A Point of View for the Prevention and Management of Type 2 Diabetes 311 Lourdes M. Varela, Almudena Ortega, Sergio Lopez, Beatriz Bermudez, Rocio Abia and Francisco J.G. Muriana

 17 Minimizing Postprandial Oxidative Stress in Type 2 Diabetes: The Role of Exercise and Selected Nutrients 321 Richard J. Bloomer, Cameron G. McCarthy and Tyler M. Farney




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