Open Access Medical Books



Edited by Kamran Alimoghaddam .

194 pages .
Open Access .

Stem cells have a prominent role in biology of normal life and also in pathogenesis of diseases.
Life starts with generation of an embryo (the most primitive form of a stem cell) and goes through all of the embryonic and fetal stages of life. It forms all of the tissue and organs of a living organism and then has a role in maintenance of normal cellular composition of body.
And finally these cells maintain body in a steady state of cell loss and substitution of normal lost/died cells by new normal cells.
Nearly in every organ of body we have these cells, although location characteristic and biological property of them is not completely understood.
Despite of their role in normal life, these cells also have a prominent role in many diseases. Deficiency/depletion of these cells is very important in pathogenesis diseases. For example aplastic anemia (a fatal form of hematopoietic stem cell disease) is stem cell damage in bone marrow, due to environmental or immunologic dysregulation.
Cancer is also a stem cell disease. Genetic/metabolic abnormalities of tissue stem cells (or some times more mature progenitor cells) may disrupt normal proliferation of immature cells in an organ and start process of carcinogenesis.
Although clinical application of the best known stem cells (Hematopoietic stem cells) is possible today and they are useful for treatment of many malignant and non-malignant disorders, clinical knowledge and application of these cells is in infancy. These cells are potentially applicable in regenerative medicine and also cancer treatment.
For safe and effective application of these cells, we need better knowledge of their biology, their interaction with other cells (especially supporting niche cells), growth, maturation and also immigration of stem cells through body in normal and abnormal conditions. Also for clinical application we need to know their characterization, their separation methods and safe manipulation.
This book is written to clarify some aspects of stem cell biology, their characteristics, assessment of damage to cells during ex vivo manipulation and also their role in a model of cancers (chronic myeloid leukemia).

Kamran Alimoghaddam, MD.
Institute for Oncology, Hematology and Stem Cell Transplantation
Tehran University of Medical Sciences, Tehran, Iran



Section 1 Stem Cell Biology .

 1 Regulators of the Proliferation of Hematopoietic Stem and Progenitor Cells During Hematopoietic Regeneration 3 Yasushi Kubota and Shinya Kimura

 2 Hematopoietic Stem Cell Niche: Role in Normal and Malignant Hematopoiesis 17 Sergio P. Bydlowski, Debora Levy, Jorge M.L. Ruiz and Juliana Pereira

 3 Expression Profile of Galectins (Gal-1, Gal-9, Gal-11 and Gal-13) in Human Bone Marrow Derived Mesenchymal Stem Cells in Different Culture Mediums 33 Faouzi Jenhani

 4 Canonical HSC Markers and Recent Achievements 51 Takao Sudo, Takafumi Yokota, Tomohiko Ishibashi, Michiko Ichii, Yukiko Doi, Kenji Oritani and Yuzuru Kanakura

 5 Hematopoietic Stem Cells and Response to Interferon 65 Atsuko Masumi

 6 Stem Cell Predictive Hemotoxicology 79 Holli Harper and Ivan N. Rich

Section 2 Stem Cells in Disease .

 7 Stem Cell-Based (Auto)Grafting: From Innovative Research Toward Clinical Use in Regenerative Medicine 111 Bela Balint, Slobodan Obradovic, Milena Todorovic, Mirjana Pavlovic and Biljana Mihaljevic

 8 Hematopoietic Stem Cells in Chronic Myeloid Leukemia 137 Antonieta Chávez-González, Sócrates Avilés-Vázquez, Dafne Moreno-Lorenzana and Héctor Mayani

 9 Role of Bone Marrow Derived Mesenchymal Stem Cells in Management of Graft Versus Host Disease 165 Aisha Nasef

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Published by: Unknown - Wednesday, May 8, 2013


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