Open Access Medical Books


Edited by Jamie Davies .
520 pages .
Open Access .

Tissue engineering is the application of knowledge gained in the study of basic developmental cell biology to the construction and repair of human bodies.
The surgically-focused side of the field has a long history, resting mainly on experience with wound healing and ad-hoc attempts to improve it. A well-known and long-standing example is modulation of bone healing by the application of physical force that gives rise to the image of a patient in traction, so common on humorous 'get well soon' cards.
The more cell biological side of the field is younger because its development had to await the gaining of significant amounts of basic knowledge in molecular cell biology, a field that is only a few decades old. The coming together of cell biology and experimental surgery to drive forward the development of tissue engineering is therefore a relatively recent phenomenon and only in this century has tissue engineering really taken off as a major area of research .
Unlike many other young sciences, tissue engineering is growing very much as a global enterprise, perhaps because of the ubiquity of surgery and therefore the visibility of obvious need. It is noticeable, for example, that the contribution of China to research into tissue engineering is currently approximately equal to that of the European Union (judged by numbers of publications on a simple search ).
This global spread of research effort stands in marked contrast to the pattern seen in other new fields such as synthetic biology, which has grown more-or-less in parallel to that of tissue engineering and which is again very much of the twenty-first century. A comparison of pie charts of the national origins of papers in the two young sciences shows the difference immediately, about a third of research in tissue engineering coming from outside the USA and the European Union while only around fifteen percent does so in synthetic biology. The
active engagement of so many countries and cultures in problems and applications of tissue regeneration ought to be a great strength for the field, encouraging the development of techniques suited to a wide range of problems and also to a wide range of health care economies.
Wherever it is done, research into tissue regeneration can be divided into three complementary sub-fields, and this book is organized around them. First, there is research that aims to understand and manipulate the endogenous healing processes in human tissues. This is the oldest part of the field. Second, there is the application of stem cell science to the regeneration of tissues (or to their de novo generation). Third, there is the construction of engineered scaffolds to guide normal healing processes and the behaviour of stem cells either in culture or in vivo. These different aspects of tissue regeneration link and overlap but, for convenience of organization, they will be considered in different sections of this book ..... 


Part 1 :  Understanding and Manipulating Endogeneous Healing of Tissues .

 1 The Role of Physical Factors in Cell Differentiation, Tissue Repair and Regeneration 13 Monica Monici and Francesca Cialdai

 2 Effect of Low-Intensity Pulsed Ultrasound on Nerve Repair 35 Jiamou Li, Hua Zhang and Cong Ren

 3 Disinfection of Human Tissues in Orthopedic Surgical Oncology by High Hydrostatic Pressure 55 Peter Diehl, Johannes Schauwecker, Hans Gollwitzer and Wolfram Mittelmeier

 4 Heparan Sulfate Proteoglycan Mimetics Promote Tissue Regeneration: An Overview 69 Johan van Neck, Bastiaan Tuk, Denis Barritault and Miao Tong

 5 Angiogenesis in Wound Healing 93 Ricardo José de Mendonça

 6 Platelet and Liver Regeneration 109 Nobuhiro Ohkohchi, Soichiro Murata and Kazuhiro Takahashi

 7 Shared Triggering Mechanisms of Retinal Regeneration in Lower Vertebrates and Retinal Rescue in Higher Ones 145 Eleonora Grigoryan

Part 2 : Application of Stem Cells .

 8 The Therapeutic Potential of Stimulating Endogenous Stem Cell Mobilization 167 Christian Drapeau, George Eufemio, Paola Mazzoni, Gerhard D. Roth and Susan Strandberg

 9 Spermatogonial Stem Cells: An Alternate Source of Pluripotent Stem Cells for Regenerative Medicine 203 Liz Simon, Marie-Claude Hofmann and Paul S. Cooke

 10 Therapeutic Application of Allogeneic Fetal Membrane-Derived Mesenchymal Stem Cell Transplantation in Regenerative Medicine 221 Shin Ishikane, Hiroshi Hosoda and Tomoaki Ikeda

 11 Mesenchymal Stem Cells in CNS Regeneration 237 Arshak R. Alexanian

 12 Therapeutic Potential of MSCs in Musculoskeletal Diseases (Osteoarthritis) 261 José Ramón Lamas, Pilar Tornero-Esteban and Benjamín Fernández-Gutiérrez

 13 Stem Cell-Mediated Intervertebral Disc Regeneration 283 Namath S. Hussain, Vickram Tejwani and Mick Perez-Cruet

 14 Towards Clinical Application of Mesenchymal Stromal Cells: Perspectives and Requirements
for Orthopaedic Applications 305 Marianna Karagianni, Torsten J. Schulze and Karen Bieback

 15 Oral Tissues as Source for Bone Regeneration in Dental Implantology 325 Dilaware Khan, Claudia Kleinfeld, Martin Winter and Edda Tobiasch

 16 Technologies Applied to Stimulate Bone Regeneration 339 Arnaldo Rodrigues Santos Jr., Christiane Bertachini Lombello and Selma Candelária Genari

Part 3 : Use of Scaffolds .

 17 Preparation of Deproteinized Human Bone and Its Mixtures with Bio-Glass and Tricalcium Phosphate – Innovative Bioactive Materials for Skeletal Tissue Regeneration 369 Magdalena Cieslik, Jacek Nocoń, Jan Rauch, Tadeusz Cieslik, Anna Ślósarczyk, Maria Borczuch-Łączka and Aleksander Owczarek

 18 Endochondral Bone Formation as Blueprint for Regenerative Medicine 399 Peter J. Emans, Marjolein M.J. Caron, Lodewijk W. van Rhijn and Tim J.M. Welting

 19 Tissue Engineering in Low Urinary Tract Reconstruction 425 Chao Feng and Yue-min Xu

 20 Novel Promises of Nanotechnology for Tissue Regeneration 453 Abir El-Sadik

Part 4 : Modeling and Assessment of Regeneration . 

21 Non-Invasive Evaluation Method for Cartilage Tissue Regeneration Using Quantitative-MRI 473 Shogo Miyata

 22 A Mathematical Model for Wound Contraction and Angiogenesis 489 Fred Vermolen and Olmer van Rijn

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Published by: Unknown - Friday, May 31, 2013


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