Open Access Medical Books



Edited by David Wagner .

Open Access .
670 pages .

This book is a compilation that includes mechanisms of type 1 diabetes pathogenesis, genetics, beta cell replacement therapy and immunotherapies. Authors have reviewed current literature on each of these topics to provide an excellent compendium on current understanding of how type 1 diabetes evolves and progresses and on the current status of treatment strategies.
The etiology of diabetes remains a mystery. There are suggestions that viral or other environmental agents are causal. The autoimmune nature of the disease including CD4+ and CD8+ T cells have been extensively explored; yet why these cells become pathogenic and the underlying causes of pathogenesis are not fully understood. The section includes description of recently defined biomarkers for pathogenic T cells.
There are many ventures in to immunotherapy, attempting to control auto-aggressive T and B cells and some of these approaches and rationales are discussed. The section on genetics covers what is known from genome – wide associated studies (GWAS) and other studies. A section on imaging includes the current status of examining beta cells during diabetogenesis and a section on beta cell replacement describes the current status of that treatment option. This book is an excellent review of the most current understanding on development of disease, imaging of disease pathogenesis and treatment opportunities.

David Wagner,
Webb-Waring Center and Department of Medicine,
University of Colorado,



Part 1 Pathogenesis .

1 Autoimmunity and Immunotherapy of Type 1 Diabetes 3 Mourad Aribi

 2 Use of Congenic Mouse Strains for Gene Identification in Type 1 Diabetes 47 Ute Christine Rogner

 3 Relationship of Type 1 Diabetes with Human Leukocyte Antigen (HLA) Class II Antigens Except for DR3 and DR4 . Masahito Katahira

 4 The Role of T Cells in Type 1 Diabetes 83 David Wagner

 5 Beta-Cell Function and Failure in Type 1 Diabetes 93 Maria-Luisa Lazo de la Vega-Monroy and Cristina Fernandez-Mejia

 6 Steady-State Cell Apoptosis and Immune Tolerance - Induction of Tolerance Using Apoptotic Cells in Type 1 Diabetes and Other Immune-Mediated Disorders 117 Chang-Qing Xia, Kim Campbell, Benjamin Keselowsky and Michael Clare-Salzler

7 Innate Immunity in the Recognition of β-Cell Antigens in Type 1 Diabetes 137 Jixin Zhong, Jun-Fa Xu, Ping Yang, Yi Liang and Cong-Yi Wang

 8 The Role of Reg Proteins, a Family of Secreted C-Type Lectins, in Islet Regeneration and as Autoantigens in Type 1 Diabetes 161 Werner Gurr

 9 Type I Diabetes and the Role of Inflammatory-Related Cellular Signaling 183 Lloyd Jesse, Kelleher Andrew, Choi Myung and Keslacy Stefan

Part 2 Pathogenesis – Virus .

 10 Echovirus Epidemics, Autoimmunity, and Type 1 Diabetes 211 Oscar Diaz-Horta, Luis Sarmiento, Andreina Baj, Eduardo Cabrera-Rode and Antonio Toniolo

Part 3 Pathogenesis – Environment .

 11 Environmental Triggers of Type 1 Diabetes Mellitus – Mycobacterium Avium Subspecies Paratuberculosis 233 Coad Thomas Dow and Leonardo A. Sechi

Part 4 Imaging .

 12 In Vivo Monitoring of Inflammation and Regulation in Type 1 Diabetes 253 Mi-Heon Lee, Sonya Liu, Wen-Hui Lee and Chih-Pin Liu

13 Imaging the Pancreatic Beta Cell 269 Ulf Ahlgren and Elena Kostromina

Part 5 Therapy .

14 Present Accomplishments and Future Prospects of Cell-Based Therapies for Type 1 Diabetes Mellitus 295 Preeti Chhabra, Clark D. Kensinger, Daniel J. Moore and Kenneth L. Brayman

Part 6 Immunotherapy .

 15 Peptides and Proteins for the Treatment and Suppression of Type-1 Diabetes 339 Ahmed H. Badawi, Barlas Büyüktimkin, Paul Kiptoo and Teruna J. Siahaan

 16 Immunotherapy for Type 1 Diabetes – Preclinical and Clinical Trials 355 Alice Li and Alan Escher

 17 Type 1 Diabetes Immunotherapy - Successes, Failures and Promises 393 Brett E. Phillips and Nick Giannoukakis

 18 Immunotherapy for Type 1 Diabetes - Necessity, Challenges and Unconventional Opportunities 409 Rachel Gutfreund and Abdel Rahim A. Hamad

 19 Autoantigen-Specific Immunotherapy 425 Shuhong Han, William Donelan, Westley Reeves and Li-Jun Yang

 20 Multi-Component Vaccines for Suppression of Type 1 Diabetes 453 William H.R. Langridge and Oludare J. Odumosu

Part 7 Beta Cell Replacement .

 21 Porcine Islet Xenotransplantation for the Treatment of Type 1 Diabetes 479 Dana Mihalicz, Ray V. Rajotte and Gina R. Rayat

 22 Beta Cell Replacement Therapy 503 Jeffrey A. SoRelle and Bashoo Naziruddin

Part 8 Genetics .

 23 Genetics of Type 1 Diabetes 529 Tatijana Zemunik and Vesna Boraska

 24 The Genetics of Type 1 Diabetes 549 Kathleen M. Gillespie

 25 Comparative Genetic Analysis of Type 1 Diabetes and Inflammatory Bowel Disease 573 Marina Bakay, Rahul Pandey and Hakon Hakonarson

 26 Genetics of Type 1 Diabetes 611 Marie Cerna

 27 Genetic Markers, Serological Auto Antibodies and Prediction of Type 1 Diabetes 631 Raouia Fakhfakh

 28 Genetic Determinants of Type 1 Diabetes 647 Mohamed M. Jahromi

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Published by: Unknown - Saturday, May 4, 2013


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