Open Access Medical Books



Edited by Illya Chaikovsky and Nataliia N. Sydorova .

Open Access .
344 pages .

This book has "wide geography" both literally and figuratively. First of all, this book brings together contributions from around the world, both from post-industrial countries and developing world.
This is natural, because coronary artery disease is becoming pandemic worldwide. CAD is the single most frequent cause of death in developed countries, causes about 1 in every 5 deaths. Mortality from cardiovascular disease is predicted to reach 23.4 million in 2030.
Moreover, in the developing world, cardiovascular disease tends to affect people at a younger age and thus could negatively affect the workforce and economic productivity. The morbidity, mortality, and socioeconomic importance of CAD make its diagnosis and management fundamental for all practicing physicians.
On another hand, the book widely represents "geography" of CAD itself, i.e. many various aspects of its pathophysiology, epidemiology, diagnosis, treatment are touched in this book.
Pathophysiologic mechanisms of CAD are well studied in general, but there are some details to be clarified. Oxidative stress is considered as one of important pathogenetic components of the atherosclerosis course, studies of its effect onto the atherosclerotic plaque formation and progression are still lasted. Section "Coronary artery disease: pathophysiology and epidemiology" includes the review “Coronary Artery Disease and Oxidative Stress”concerning this problem. 
Another chapter in this Section is an epidemiological research demonstrating capabilities of the modern genetic risk factors in improvement of the ability to predict incident CAD beyond that afforded by traditional non genetic risk factors.
Section "Coronary artery disease: diagnostic features" begins with the chapter "Magnetocardiography in Unshielded Setting: Heart Electrical Image based on 2-D and 3-D Data in Comparison with Perfusion Image Based on PET Results", devoted to the promising technique of investigation of the cardiac electrical generator – magnetocardiography (MCG). Comparison is drawn of the cardiac imaging on the base of current density distribution maps, obtained by MCG and PET images. Two other articles of this Section are devoted to the different issues of the modern advanced resting electrocardiography, demonstrating that capabilities of this oldest technique of instrumental diagnosis in cardiology are far from completed. Exercise stress test is sometimes figuratively called "workhorse" in diagnosis of CAD. Authors of the chapter "Quantitative Functional Assessment of Ischemic Patients by Cardiopulmonary Exercise and Recovery Indices" emphasize important contribution of the cardiopulmonary indices for quantitative functional assessment of patients with CAD. Laboratory diagnostics is represented by the chapters "Oxidized low density lipoprotein, statin therapy and carotid stenosis", continuing the topic of oxidative stress impact onto the course of CAD and “Relationship Between the Serum 7-ketocholesterol Concentrations and Coronary Artery Disease” representing the measuring system for evaluation of the serum 7-ketocholesterol concentrations. Also clinical significance of 7KCHO is discussed.

Treatment of the coronary artery disease is continuously improved and developed. New evidences appear for effectiveness of modern therapeutic and surgical approaches. Section "Treatment for coronary artery disease" begins with the chapter "Evaluation of Anti-ischemic Therapy in Coronary Artery Disease" with detailed description of the modern treatment of patients with this disease. No doubt, that nowadays surgical revascularization – is one of the basic therapeutic interventions in CAD patients. In chapter "Coronary Arterial Drug-Eluting Stent: From Its Structure to Clinic" features and advantages of the drug-eluting stents available for clinical practice are discussed, demonstrating their future prospects. The subject with growing popularity of stem cells is covered in chapter "Pursuing Candidate Stem Cells for Candidate Regeneration in Patients Suffered from Acute Coronary Syndrome".
This book also contains the Section "Coronary artery disease and comorbidities" discussing such comorbidities as thyroid dysfunction ("Impact of Thyroid Dysfunction on Natural Course of Coronary Artery Disease", systemic vasculitis ("Coronary Artery Disease and Systemic Vasculitis: Case Report and Review"), professional stress ("Occupational Stress and Coronary Artery Disease"), migraine (“Endothelial Function in Migraine”) and arterial hypertension (“Specific features of Target Organ Damage in Patients with Arterial Hypertension and Coronary Artery Disease”) et al. This book does not pretend on complete and integral description of the Coronary artery disease. Rather, it contains selected issues of this complex multifactorial disease. 
Nevertheless, we hope that readers will find Coronary Artery Disease useful for clinical practice and further research.

Illya Chaikovsky, 
MD PhD multiple, Senior research fellow, Assoc Prof,
International Research 
and Training Center for Informational Technologies and
Systems of National Academy of Science, Kyiv,
Nataliia Sydorova, MD PhD, Assoc Prof,
Ukrainian Military Medical Academy, Kyiv,



Part 1 Coronary Artery Disease: Pathophysiology and Epidemiology .

1 Coronary Artery Disease and Oxidative Stress 3 Mara S. Benfato, Tássia M. Medeiros and Tiago B. Salomon

 2 Prediction of Coronary Heart Disease Risk in a South European Population: A Case-Control Study 25 Maria Isabel Mendonça, Roberto Palma Reis and António Brehm

Part 2 Coronary Artery Disease: Diagnostic Features .

 3 Magnetocardiography in Unshielded Setting: Heart Electrical Image Based on 2-D and 3-D Data in Comparison with Perfusion Image Based on PET Results – Clinical Cases 43 Illya Chaikovsky, Michael Primin, Igor Nedayvoda and Mykola Budnyk

 4 Quantitative Functional Assessment of Ischemic Patients by Cardiopulmonary Exercise and Recovery Indices 59 Eliezer Klainman, Alex Yarmolovsky and Gershon Fink

 5 LBBB: The ECG Patterns and Cardiac Function in Patients With and Without Coronary Artery Disease 83 Marwan Badri, William Kornberg, James F. Burke, Peter R. Kowey and Li Zhang

 6 Characterization of Repolarization Alternans in the Coronary Artery Disease 91 Laura Burattini and Roberto Burattini

 7 Relatioship Between Serum 7-Ketocholesterol Concentrations and Coronary Artery Disease 111 Takashi Hitsumoto and Kohji Shirai

 8 Oxidized Low Density Lipoprotein, Statin Therapy and Carotid Stenosis 125 Elias Skopelitis, Dimitrios Levisianou, Theodore Gialernios and Sofoklis Kougialis

Part 3 Treatment for Coronary Artery Disease .

 9 Evaluation of Anti-Ischemic Therapy in Coronary Artery Disease: A Review 151 Marwan S.M. Al-Nimer

 10 Coronary Arterial Drug-Eluting Stent: From Structure to Clinical 197 Tim Wu and Stephen McCarthy

 11 Pursuing Candidate Stem Cells for Optimal Cardiac Regeneration in Patients Suffered from Acute Coronary Syndrome 225 Mohaddeseh Behjati

Part 4 Coronary Artery Disease and Comorbidities .

 12 Impact of Thyroid Dysfunction on Natural Course of Coronary Artery Disease 261 Nataliia N. Sydorova

 13 Coronary Artery Disease and Systemic Vasculitis: Case Report and Review 281 Damianos Eleftheriadis and Nikolaos Eleftheriadis

 14 Occupational Stress and Coronary Artery Disease 301 Sheng Wang and Dou Chang

 15 Specific Features of Target Organ Damage in Patients with Arterial Hypertension and Coronary Artery Disease 317 Corina Şerban, Ruxandra Christodorescu, Alexandru Caraba, Germaine Săvoiu, Carmen Cristescu and Simona Drăgan

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Published by: Unknown - Tuesday, May 14, 2013


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