Open Access Medical Books



Edited by Kyuzi Kamoi .

148 pages .
Open Access .

This primary aim of this publication is to show recent scientific findings regarding clinical problems of diabetes insipidus (DI) to all readers.
In a clinical setting, DI is divided into 4 types which are consisted of neurogenic, nephrogenic, dipsogenic (primary polydipsia) and gestational types. In 1794, DI was separated from diabetes mellitus by Dr. Frank JP who first defined DI in the world. After that, the investigation of pathophysiology in DI has proceeded with the development of science.
Secretions of blood vasopressin (AVP) are clarified by the developments of measuring method and more adequate test for AVP secretion. Moreover, the development of MRI imaging on the pituitary gland with the stalk and hypothalamus gives us more evidentiary information. Non‐inflammatory diseases as pathophysiology of DI from idiopathic causes are elucidated and the pathophysiology of nephrogenic DI and gestational DI has been more clarified.
However, there are many unsolved problems in the field. For example, although adipsic DI in neurogenic types is a rare disorder, its management is difficult. The main factor may be caused by disturbance of the osmoreceptor. The osmoreceptor is a theoretical concept and is not yet concretely established by recent scientific developments. Further, it is crucial to measure plasma AVP in DI. However, as it is difficult to measure plasma AVP easily in the world, other methods except plasma AVP have been searched. Among the methods, there is hope in the measurement of plasma copeptin. Regarding clinical problems, differential diagnosis of autoimmune diseases with other causes is not easy. It needs to have a method for detecting the autoantibody for autoimmunity of DI simply and trustworthily. In the gene, although some types have demonstrated relation to gene abnormality, it is not clear to how the gene abnormality causes the DI.
The authors have contributed significant scientific findings and I hope that readers understand the recent pathophysiology of DI.

Prof. Kyuzi Kamoi
Niigata Prefecture University



 1 Management of Langerhans Cell Histiocytosis (LCH)-Induced Central Diabetes Insipidus and Its Associated Endocrinological/Neurological Sequelae 1 Shinsaku Imashuku and Akira Morimoto

 2 Diabetes Insipidus and Traumatic Brain Injury 11 Yi-Chun Chou, Tzu-Yuan Wang and Li-Wei Chou

 3 Management of Neuroendocrine Instability During Maintenance of Potential Organ Donors 23 Luciana Mascia, Ilaria Mastromauro and Silvia Grottoli

 4 Nephrogenic Diabetes Insipidus – The Novelly Potential Therapeutic Drugs 41 Jessica Y.S. Chu and Billy K.C. Chow

 5 Analysis of Membrane Protein Stability in Diabetes Insipidus 53 Florian Heinke, Anne Tuukkanen and Dirk Labudde

 6 New Insights into the Diagnosis and Management of Pregnancy-Related Diabetes Insipidus 79 Carmen Emanuela Georgescu

 7 A Case of Central Diabetes Insipidus in a Female Patient with Bipolar Disorder, Lithium Consumer Over the Last Years 101 Emilio González Pablos, Cristina Gil-Díez Usandizaga, Maite Cañas Cañas, Rosa Sanguino Andrés and Luis A. Flores

 8 Imaging Manifestations and Techniques in Diabetes Insipidus 109 Nirmal Phulwani, Tulika Pandey, Jyoti Khatri, Raghu H. Ramakrishnaiah, Tarun Pandey and Chetan C. Shah

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Published by: Unknown - Saturday, May 4, 2013


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