Open Access Medical Books



Edited by Raimondo De Cristofaro .

92 pages .
Open Access .

Microangiopathies are pathological processes causing degenerative disorders of small vessels and involved in a wealth of different diseases. The circulatory problems stemming from microangiopathic disorders may be responsible for failure of individual or multiple organs. Microangiopathies are indeed one of the most common disorders characterized by high morbility and mortality in the affected patients. The knowledge of the mechanisms involved in the genesis of microangiopathies has been strongly expanded in the past few years. Many studies have revealed very complicated processes both at cellular and molecular level. However, much work remains to define the diversity of different pathogenetic mechanisms leading to microangiopathic disorders to provide appropriate prevention and treatment strategies.
This volume contains four informative chapters contributed by experts in their field and provides illustrative examples of relevant mechanisms responsible for different forms of microangiopathies and how this body of evidences can be harnessed to define new strategies of therapeutic intervention.
In Chapter 1, Lancellotti et al. analyze the canonical forms of thrombotic microangiopathies arising from perturbation of the proteolytic processing of von Willebrand factor due to deficiency of ADAMTS13 activity. The main mechanisms of these disorders in the canonical and atypical forms were analyzed and discussed together with old and novel therapeutic strategies used to contrast both the cause and the effects of these diseases.
In Chapter 2 Narimatsu reviews from a pathological and clinical standpoint a particular form of thrombotic microangiopathy that frequently occurs in the intestinal vessels in hematopoietic stem-cell transplantation recipients. In the same chapter Fatih Erbey reviews the transplant-associated thrombotic microangiopathy with emphasis on the clinical and therapeutic aspects concerning pediatric patients.
In chapter 3 Kuang-Yu Jen and Zoltan G. Laszik analyzes the pathologic manifestations and molecular pathologenesis of preeclampsia with a special emphasis on the renal effects of this disease.

Finally, in chapter 4 Vojtková et al. review the ethiopathogenesis of the main microangiopathic complications of diabetes mellitus, that are responsible for retinopathy, nephropathy and neuropathy, which heavily affect the morbility and mortality of this increasingly diffuse disease.
I thank all the authors for their excellent contributions and their efforts to submit updated and outstanding chapters. Expert editorial assistance from Romana Vukelic is gratefully acknowledged, especially because she made possible the timely conclusion of the project and was always a valuable source of valuable suggestions.

Prof. Raimondo De Cristofaro
Department of Internal Medicine and Medical Specialties,
Haemostasis Research Center, Catholic University School of Medicine



Part 1 Stem Cells Transplantation-Associated Microangiopathies .

 1 Intestinal Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplantation
Hiroto Narimatsu

 2 Transplant-Associated Thrombotic Microangiopathy in Childhood 9 Fatih Erbey

Part 2 Eclampsia-Associated Microangiopathy .

 3 Renal Effects of Preeclampsia 25 Kuang-Yu Jen and Zoltan G. Laszik

Part 3 Diabetic Microangiopathy .

 4 Diabetic Microangiopathy – Etiopathogenesis, New Possibilities in Diagnostics and Management 37 Jarmila Vojtková, Miriam Čiljaková and Peter Bánovčin

Part 4 Thrombotic Microangiopathies: Perturbation of the VWF-ADAMTS13 Pathway .

 5 Von Willebrand Factor-Mediated Thrombotic Microangiopathies 69 Leonardo Di Gennaro, Stefano Lancellotti and Raimondo De Cristofaro

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Published by: Unknown - Monday, May 6, 2013


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