Open Access Medical Books



Edited by Hiroyuki Shimada .

Open Access .
310 pages . 

Cancers of neuroblastoma type are heterogenous and their molecular/genomic properties are closely associated with the prognosis of patients: certain children enjoy an excellent clinical course after biopsy/surgery alone, and others suffer from a lethal result even after an intensive treatment. Current development has also began disclosing critical significance of crosstalking between neuroblastoma cells and their microenvironment in predicting clinical attitudes of individual situations. In this ebook, the world distinguished investigators report clinical and biological properties of this disease. It now becomes very clear that we should identify specific “targets” and include them in our future strategy development for efficiently managing the patients with neuroblastoma. We believe that these “targets” can only be identified by understanding more of the biology of this complex disease. We need to keep up our continuous effort in precise medicine, so that we will be able to reach our goal, i.e., cure for this disease, in a near future.

Hiroyuki Shimada, MD, PhD
Department of Pathology & 
Laboratory Medicine Children's Hospital
Los Angeles, 


Section 1 of the Textbook : Neuroblastoma, Clinical .

 1 Clinical Presentation of Neuroblastoma 3 Josef Malis

 2 A Novel Diagnostic Tool for Therapy Stratification of Neuroblastoma: Preoperative Analysis of Tumor Biology Using Circulating Tumor-Released DNA in Serum 13 Shigeki Yagyu, Tomoko Iehara and Hajime Hosoi

Section 2 of the Textbook : Neuroblastoma, Biology I .

 3 Close Neighbours on Chromosome 2 the ALK and MYCN Genes. Implications for Targeted Therapeutics in Neuroblastoma 25 Fergal C. Kelleher

 4 Neurotrophin and Neurotrophin Receptor Involvement in Human Neuroblastoma 47 Pierdomenico Ruggeri, Antonietta R. Farina, Lucia Cappabianca, Natalia Di Ianni, Marzia Ragone, Stefania Merolle, Alberto Gulino and Andrew R. Mackay

 5 Connexin36 is a Negative Regulator of Differentiation in Human Neuroblastoma 109 Mandeep Sidhu and Daniel J. Belliveau

 6 Pathways of Intrinsic Apoptosis in Neuroblastoma: Targets for Therapeutics and New Drug Development 131 Fieke Lamers and Aru Narendran

 7 Analysis of Apoptotic and Autophagic Pathways in Neuroblastoma by Treatment with Copper Compounds 145 Enrique Hernández-Lemus, Anllely Grizett Gutiérrez, Adriana Vázquez-Aguirre, M. Lourdes Palma-Tirado, Lena Ruiz-Azuara and Carmen Mejía

Section 3 of the Textbook : Neuroblastoma, Biology II .

 8 Bone Marrow Infiltration in Neuroblastoma: Characteristics of Infiltrating Cells and Role of the Microenvironment 165 Fabio Morandi, Paola Scaruffi, Sara Stigliani, Barbara Carlini and Maria Valeria Corrias

 9 Neuroblastoma Integrins 189 Shanique A. Young, Ryon Graf and Dwayne G. Stupack

Section 4 of the Textbook : Neuroblastoma, Biology III .

 10 Novel Therapeutic Approaches for Neuroblastoma 219 Shweta Joshi, Alok R. Singh, Lisa L.R. Hartman, Muamera Zulcic, Hyunah Ahn and Donald L. Durden

 11 miRNAs as Essential Mediators of the Actions of Retinoic Acid in Neuroblastoma Cells 247 Salvador Meseguer, Juan-Manuel Escamilla and Domingo Barettino

 12 Copper as a Target for Treatment of Neuroblastoma: Molecular and Cellular Mechanisms 265 Emanuela Urso and Michele Maffia

 13 Clinical Implications of Neuroblastoma Stem Cells 291 Xao X. Tang and Hiroyuki Shimada

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Published by: Unknown - Wednesday, May 29, 2013


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