Open Access Medical Books



Edited by Uday Kishore .

638 pages .
Open Access .

It is my pleasure to present to you this book that I edited with great interest and anticipation. My own research interests include examining the role of complement proteins in neuroinflammation and neurodegeneration using the models of Alzheimer’s disease as well as British and Danish familial dementia. However, through my own studies and during the course of editing this book, it became evident that one needs to have a holistic view about the pathophysiology of various neurodegenerative diseases. These are multi-factorial and complex disease processes that require a range of multi-disciplinary approaches from various angles and directions in order to achieve diagnostic and therapeutic outcomes. This book is a small but significant step in highlighting the complexities of issues relevant for basic and translational research in the area of neuroinflammation and neurodegeneration.
The book has three major sections addressing disease mechanisms and therapeutic interventions in Alzheimer’s disease, followed by generic mechanisms in other forms of the neurodegenerative diseases. The book ends with its last miscellaneous section that is a small conglomeration of chapters on Spinal Muscular Atrophy, Acute Ischemic Stroke, and Cognitive dysfunction syndrome. I sincerely hope that this book is an exciting point of reference for many clinical and non-clinical neuroscientists.
I am ever so indebted to all the authors who have contributed various chapters for this book. I am also grateful to Daria Nahtigal and Iva Simcic of the InTech Europe for inviting me to edit this book. I would like to thank Dr Annapurna Nayak, Dr Patrick Waters, Dr Marco Bonifati, Dr Abhishek Shastri and Dr Janez Ferluga for stimulating discussions during the course of editing this book. Many thanks are also due to Prof Bob Sim, Prof Nick Willcox and Prof Angela Vincent for priming me into the field of neuroimmunology.

Dr Uday Kishore
Centre for Infection, Immunity and Disease Mechanisms
Brunel University
London, UK



Section 1 Disease Mechanisms in Alzheimer's Disease .

 1 Alzheimer’s Disease: A Clinical Perspective 3 Weili Xu, Anna Marseglia, Camilla Ferrari and Hui-Xin Wang

 2 Late-Onset Alzheimer's Disease: Risk Factors, Clinical Diagnosis and the Search for Biomarkers 35 Marisol Herrera-Rivero

 3 Role of Protein Aggregation in Neurodegenerative Diseases 55 Yusuf Tutar, Aykut Özgür and Lütfi Tutar

 4 Role of Oxidative Stress in Aβ Animal Model of Alzheimer's Disease: Vicious Circle of Apoptosis, Nitric Oxide and Age 77 Ferihan Cetin

 5 Alterations of Mitochondria and Golgi Apparatus Are Related to Synaptic Pathology in Alzheimer's Disease 101 Stavros J. Baloyannis

 6 Caspases in Alzheimer’s Disease 125 Yan Zhang

 7 Brain Reserve Regulators in Alzheimer’s Disease 151 Ivana Delalle

 8 Cholesterol and Alzheimer's Disease 165 Iuliana Nicola-Antoniu

Section 2 Therapeutic Aspects of Alzheimer .

 9 Emerging Therapeutic Strategies in Alzheimer's Disease 181 Tomohiro Chiba

 10 Dropping the BACE: Beta Secretase (BACE1) as an Alzheimer’s Disease Intervention Target 227 Justin Read and Cenk Suphioglu

 11 QSAR Analysis of Purine-Type and Propafenone-Type Substrates of P-Glycoprotein Targeting β-Amyloid Clearance 257 Jie Yang and Jie Chen

 12 Therapeutic Interventions in Alzheimer Disease 291 Analava Mitra and Baishakhi Dey

Section 3 Pathopysiological Aspects of Other Neurodegenerative Diseases .

 13 Other Dementias 321 Abhishek Shastri, Domenico Marco Bonifati and Uday Kishore

 14 The Role of Epigenetics in Neurodegenerative Diseases 345 Luca Lovrečić, Aleš Maver, Maja Zadel and Borut Peterlin

 15 Plasma Membrane Channels Formed by Connexins or Pannexins in Microglia: Possible Role in the Inflamed Brain 367 Juan A. Orellana

 16 Influence of Obesity on Neurodegenerative Diseases 381 Rana Awada , Avinash Parimisetty and Christian Lefebvre d’Hellencourt

 17 Electro-Physiological Approaches to Monitoring Neuro- Degenerative Diseases 403 Manuel J. Rojas, Camilo Orozco and Francisco Olea

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Published by: Unknown - Thursday, May 16, 2013


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