Open Access Medical Books



Edited by Andrea Luigi Tranquilli .

226 pages .
Open Access . 

Thrombophilia is a condition in which the blood tends to hypercoagulate and form clots. Such tendency is enhanced under special conditions like the prolonged immobility, surgical stress, and pregnancy.
Although it is conceivable that thrombophilia carriers are mostly prone to thrombotic events, those events are rare, and not necessarily a person who carries the risk will ever undergo one of them in the whole lifetime. Thombophilia is not a disease. It is only a condition that creates greater risks in special situations. There are inherited and acquired thrombophilias. The biologic research focused on the first has rapidly expanded in recent years, for the availability of genetic tests and molecular biology.
Those tests allowed to design a new epidemiology of this phenomenon and to establish new connections between thrombotic events and the carrier status.
Pregnancy has become one of the most studied conditions with surprising results. Two situations are of crucial interest in pregnancy. Venous thromboembolism and its correlates is the first. Venous thromboembolism in pregnancy and puerperium is still one of the leading causes of maternal mortality. It increases with maternal age (and maternal age is increasing in industrial countries) and with caesarean section (this is constantly increasing as well). The second situation is the association between thrombophilia and medical and obstetric disorders in pregnancy (hypertension, preeclampsia, placental abruptio, intrauterine growth restriction, intrauterine fetal death, but also miscarriage and recurrent miscarriage), that is the placental involvement with fetal outcomes, besides the maternal thrombotic involvement. Those associations triggered an extraordinary scientific interest and the tendency to follow two clinical shortcuts: the idea of a large, universal, screening, and the pharmacologic prophylactic intervention. Not having yet large randomized clinical studies, today the indications are somehow empirical, and many of the most recent guidelines give controversial and often restrictive statements, mostly money saving-oriented and nonbeneficially proved.
The aim of this book was to go deep in the problem and give to the reader a chance to form his/her own opinion in studying and treating patients at risk or carrier of a thrombophilic state. I hope we were able to accomplish this mission.

This book is dedicated to Prof. Pietro Leoni MD, Professor of Hematology in Ancona, and to my wife Monica.

Andrea Luigi Tranquilli
Department of Obstetrics and Gynecology,
Polytechnic University of Marche, Ancona,



Part 1 Thrombophilia .

 1 Inherited Thrombophilia: Past, Present, and Future Research 3 Jorine S. Koenderman and Pieter H. Reitsma

 2 Association of Haemostasis Activation Markers with Thrombophilia and Venous Thromboembolism 23 Tjaša Vižintin-Cuderman, Mojca Božič-Mijovski, Aleksandra Antović, Polona Peternel, Matija Kozak and Mojca Stegnar

 3 Geographic and Ethnic Differences in the Prevalence of Thrombophilia 39 Lizbeth Salazar-Sanchez

 4 Inherited Thrombophilia and the Risk of Vascular Events 59 Ivana Novaković, Dragana Cvetković and Nela Maksimović

 5 APC Resistance 75 Gerry A.F. Nicolaes

Part 2 Thrombophilia and Pregnancy .

 6 Inherited and Acquired Thrombophilia in Pregnancy 99 Feroza Dawood

 7 The Impact of Inherited Thrombophilia on Placental Haemostasis and Adverse Pregnancy Outcomes 121 Joanne M. Said

 8 Infertility and Inherited Thrombophilia 143 Ricardo Barini, Adriana Goes Soligo, Joyce Annichino-Bizzachi and Egle Couto

 9 Thrombophilia and Recurrent Pregnancy Loss 151 Gokalp Oner

 10 Pathogenic Mechanisms of Thrombosis in Antiphospholipid Syndrome (APS) 161 Marina P. Sikara, Eleftheria P. Grika and Panayiotis G. Vlachoyiannopoulos

 11 Adverse Pregnancy Outcome in Antiphospholipid Antibodies Syndrome: Pathogenic Mechanisms and Clinical Management 187 Nicoletta Di Simone and Chiara Tersigni

 12 Fetal Thrombophilia 203 Stefano Raffaele Giannubilo and Andrea Luigi Tranquilli

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Published by: Unknown - Monday, May 6, 2013


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