Open Access Medical Books



Edited by David Wagner .

492 pages . 
Open Access .

This book is a compilation that includes reviews on type 1 diabetes onset, complications of cardio, vascular, retinal, oral health and potential treatment options.
Authors have reviewed current literature on each of these topics to provide an excellent compendium on current understanding of how type 1 diabetes evolves and progresses with more emphasis on diabetic complications and on the current status of treatment strategies.
The etiology of diabetes remains a mystery. There is discussion about the genetic predisposition and more detailed complications including neural, nephropathy and co-morbidity in youth. The autoimmune nature of the disease including CD4+ and CD8+ T cells have been extensively explored; yet why these cells become pathogenic and the underlying causes of pathogenesis are not fully understood. This book is an excellent review of the most current understanding on development of disease with focus on diabetes complications.

David Wagner,
Webb-Waring Center and Department of Medicine, University of Colorado,



Part 1 Diabetes Onset .

 1 Genetic Determinants of Microvascular Complications in Type 1 Diabetes 3 Constantina Heltianu, Cristian Guja and Simona-Adriana Manea

 2 Early and Late Onset Type 1 Diabetes: One and the Same or Two Distinct Genetic Entities? 29 Laura Espino-Paisan, Elena Urcelay, Emilio Gómez de la Concha and Jose Luis Santiago

 3 Islet Endothelium: Role in Type 1 Diabetes and in Coxsackievirus Infections 55 Enrica Favaro, Ilaria Miceli, Elisa Camussi and Maria M. Zanone

 4 Type 1 Diabetes Mellitus and Co-Morbidities 85 Adriana Franzese, Enza Mozzillo, Rosa Nugnes, Mariateresa Falco and Valentina Fattorusso

 5 Hypoglycemia as a Pathological Result in Medical Praxis 109 G. Bjelakovic, I. Stojanovic, T. Jevtovic-Stoimenov, Lj.Saranac, B. Bjelakovic, D. Pavlovic, G. Kocic and B.G. Bjelakovic

 6 Autoimmune Associated Diseases in Pediatric Patients with Type 1 Diabetes Mellitus According to HLA-DQ Genetic Polymorphism 143 Miguel Ángel García Cabezas and Bárbara Fernández Valle

Part 2 Cardiovascular Complications .

 7 Etiopathology of Type 1 Diabetes: Focus on the Vascular Endothelium 157 Petru Liuba and Emma Englund

 8 Cardiovascular Autonomic Dysfunction in Diabetes as a Complication: Cellular and Molecular Mechanisms 167 Yu-Long Li

 9 Microvascular and Macrovascular Complications in Children and Adolescents with Type 1 Diabetes 195 Francesco Chiarelli and M. Loredana Marcovecchio

 10 Type 1 Diabetes Mellitus: Redefining the Future of Cardiovascular Complications with Novel Treatments 219 Anwar B. Bikhazi, Nadine S. Zwainy, Sawsan M. Al Lafi, Shushan B. Artinian and Suzan S. Boutary

 11 Diabetic Nephrophaty in Children 245 Snezana Markovic-Jovanovic, Aleksandar N. Jovanovic and Radojica V. Stolic

 12 Understanding Pancreatic Secretion in Type 1 Diabetes 261 Mirella Hansen De Almeida, Alessandra Saldanha De Mattos Matheus and Giovanna A. Balarini Lima

Part 3 Retinopathy .

 13 Review of the Relationship Between Renal and Retinal Microangiopathy in Type 1 Diabetes Mellitus Patients 281 Pedro Romero-Aroca , Juan Fernández-Ballart, Nuria Soler, Marc Baget-Bernaldiz and Isabel Mendez-Marin

 14 Ocular Complications of Type 1 Diabetes 293 Daniel Rappoport, Yoel Greenwald, Ayala Pollack and Guy Kleinmann

Part 4 Treatment .

 15 Perspectives of Cell Therapy in Type 1 Diabetes 323 Maria M. Zanone, Vincenzo Cantaluppi, Enrica Favaro, Elisa Camussi, Maria Chiara Deregibus and Giovanni Camussi

 16 Prevention of Diabetes Complications 353 Nepton Soltani

 17 The Enigma of -Cell Regeneration in the Adult Pancreas: Self-Renewal Versus Neogenesis 367 A. Criscimanna, S. Bertera, F. Esni, M. Trucco and R. Bottino

 18 Cell Replacement Therapy: The Rationale for Encapsulated Porcine Islet Transplantation 391 Stephen J. M. Skinner, Paul L. J. Tan, Olga Garkavenko, Marija Muzina, Livia Escobar and Robert B. Elliott

Part 5 Diabetes and Oral Health .

 19 Dental Conditions and Periodontal Disease in Adolescents with Type 1 Diabetes Mellitus 411 S. Mikó and M. G. Albrecht

 20 Impact of Hyperglycemia on Xerostomia and Salivary Composition and Flow Rate of Adolescents with Type 1 Diabetes Mellitus 427 Ivana Maria Saes Busato, Maria Ângela Naval Machado, João Armando Brancher, Antônio Adilson Soares de Lima, Carlos Cesar Deantoni, Rosângela Réa and Luciana Reis Azevedo-Alanis

 21 The Effect of Type 1 Diabetes Mellitus on the Craniofacial Complex 437 Mona Abbassy, Ippei Watari and Takashi Ono

 22 The Role of Genetic Predisposition in Diagnosis and Therapy of Periodontal Diseases in Type 1 Diabetes Mellitus 463 M.G.K. Albrecht

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Published by: Unknown - Saturday, May 4, 2013


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