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CURRENT BASIC AND PATHOLOGICAL APPROACHES TO THE FUNCTION OF MUSCLE CELLS AND TISSUES – FROM MOLECULES TO HUMANS

TEXTBOOK : CURRENT BASIC AND PATHOLOGICAL APPROACHES TO THE FUNCTION OF MUSCLE CELLS AND TISSUES – FROM MOLECULES TO HUMANS

Edited by Haruo Sugi .

Open Access .
400 pages .
ISBN 978-953-51-0679-1 .


This volume consists of 17 short review articles, originally submitted to the Editor under the theme of “Muscle Cell”. Muscles are classified into three types, skeletal, cardiac and smooth muscles, according to their structure and function. In vertebrate animals including humans, skeletal muscle produces body movement, cardiac muscle is responsible for the heart function as a pump, and smooth muscle is distributed among various visceral organs and blood vessels to keep the animals alive. In all kinds of muscle, mechanical activity results from relative sliding of actin and myosin filaments coupled with ATP hydrolysis, though the mechanism of the myofilament sliding still remains to be a matter for debate and speculation. On the other hand, the mechanical activity of muscle is controlled by changes in the intracellular concentration of free Ca2+ ions. In skeletal muscle, contraction is initiated by the release of Ca2+ ions from the intracellular membranous structure, sarcoplasmic reticulum, while in cardiac muscle contraction is mainly coupled with influx of Ca2+ ions from the extracellular space. In smooth muscles, the origin of Ca2+ ions activating contraction, i.e. activator Ca2+, is variable and is not yet fully understood, reflecting the complex structure of smooth muscle tissues. Fifty years ago, smooth muscles were sometimes called “headache muscle” because of extreme technical difficulties in studying their function. As the readers will become aware, considerable progress has now been achieved on the research field of smooth muscle cells and tissues, and smooth muscles are no longer “headache muscle”.
For the sake of convenience for general readers, the book is divided into three parts according to the subjects of articles. Part I includes articles dealing with basic aspects of function of skeletal and smooth muscle cells, and also melanocytes which have many properties common to those of smooth muscles. Part II contains articles dealing with pathological aspects of cardiac and smooth muscle cell functions, while Part III consists of articles concerning factors influencing structure and function of cardiac and smooth muscle cells and tissues.
The Editor believes that these articles are extremely stimulating and informative for the readers who are interested not only in the basic mechanisms of muscle cell function, but also in the pathological and clinical aspects of muscle cells and tissues.

Dr. Haruo Sugi
Emeritus Professor, Teikyo University,
Japan
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CONTENTS : 


Section 1 Contractile and Regulatory Mechanisms of Contraction in Skeletal, Cardiac and Smooth Muscle Cells .


 1 The Gas Environmental Chamber as a Powerful Tool to Study Structural Changes of Living Muscle Thick Filaments Coupled with ATP Hydrolysis 3 Haruo Sugi, Hiroki Minoda, Takuya Miyakawa, Suguru Tanokura, Shigeru Chaen and Takakazu Kobayashi

 2 Calcium Cycling in Synthetic and Contractile Phasic or Tonic Vascular Smooth Muscle Cells 27 Larissa Lipskaia, Isabelle Limon, Regis Bobe and Roger Hajjar

 3 The Role of Sodium-Calcium Exchanger in the Calcium Homeostasis of Airway Smooth Muscle 45 Ricardo Espinosa-Tanguma, Paola Algara-Suárez, Rebeca Mejía-Elizondo and Víctor Saavedra-Alanís

 4 Contraction by Ca2+ Influx via the L-Type Ca2+ Channel Voltage Window in Mouse Aortic Segments is Modulated by Nitric Oxide 69 Paul Fransen, Cor E. Van Hove, Johanna van Langen and Hidde Bult

 5 MAP Kinase-Mediated and MLCK-Independent Phosphorylation of MLC20 in Smooth Muscle Cells 93 Maoxian Deng, Lixia Deng and Yarong Xue

 6 Two Guanylylcyclases Regulate the Muscarinic Activation of Airway Smooth Muscle 113 Marcelo J. Alfonzo, Fabiola Placeres-Uray, Walid Hassan-Soto, Adolfo Borges, Ramona González de Alfonzo and Itala Lippo de Becemberg

 7 Melanophores: Smooth Muscle Cells in Disguise 133 Saima Salim and Sharique A. Ali

Section 2 Pathological Aspects of Cardiac and Smooth Muscle Cells .


 8 Cardiomyocyte and Heart Failure 161 Shintaro Nakano, Toshihiro Muramatsu, Shigeyuki Nishimura and Takaaki Senbonmatsu

 9 Implication of MicroRNAs in the Pathophysiology of Cardiac and Vascular Smooth Muscle Cells 183 Valérie Metzinger-Le Meuth, Eléonore M'Baya-Moutoula, Fatiha Taibi, Ziad Massy and Laurent Metzinger

 10 Cardiovascular Lesions of Kawasaki Disease: From Genetic Study to Clinical Management 207 Ho-Chang Kuo and Wei-Chiao Chang

 11 Vascular Smooth Muscle Cells and the Comparative Pathology of Atherosclerosis 233 Hafidh I. Al-Sadi

 12 Choroidal Vessel Wall: Hypercholesterolaemia-Induced Dysfunction and Potential Role of Statins 255 J.M. Ramírez, J.J. Salazar, R. de Hoz, B. Rojas, B.I. Gallego, A.I. Ramírez and A. Triviño

Section 3 Factors Influencing Structure and Function of Smooth Muscle Cells and Tissues .


 13 Different Modulators of Airways and Distal Lung Parenchyma Contractile Responses in the Physiopathology of Asthma 301 Carla Máximo Prado, Edna Aparecida Leick, Fernanda Degobbi Tenório Quirino dos Santos Lopes, Milton A. Martins and Iolanda de Fátima Lopes Calvo Tibério

 14 Regulation of Differentiated Phenotypes of Vascular Smooth Muscle Cells 331 Sho Shinohara, Satoko Shinohara, Takanori Kihara and Jun Miyake

 15 Structure and Function of Smooth Muscle with Special Reference to Mast Cells 345 Angel Vodenicharov

 16 Role of Prokineticin in Epicardial Progenitor Cell Differentiation to Regenerate Heart 363 Canan G. Nebigil

 17 Hypoxic Pulmonary Vascular Smooth Muscle Cell Proliferation 379 Shiro Mizuno, Hirohisa Toga and Takeshi Ishizaki .



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Published by: younes younes - Friday, June 28, 2013

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