Open Access Medical Books



Edited by Stevo Najman .

574 pages .
Open Access .
ISBN 978-953-51-0544-2 .

A numerous internationally renowned authors in the pages of this book present the views of the fields of cell biology and their own research results or review of current knowledge. As a multidisciplinary field, cell biology is difficult to describe by limiting it to some discipline or field. As a rule, the fields are overlapping, and the content of this book is split into sections only according to the estimation of the editor what is the primary focus of the chapter. Sections are dedicated to cell structures and functions, genetic material, regulatory mechanisms, cellular biomedicine and new methods in cell biology. Multidisciplinary and often quite versatile approach by many authors have imposed restrictions of this classification, so it is certain that many chapters could belong to the other sections of this book. Most of the chapters deal with fundamental as well as applicative aspects of discussed topics. The current frontiers, on the manner in which they described in the book, can be a good inspiration to many readers for further improving, and perspectives which are highlighted can be seen in many areas of fundamental biology, biomedicine, biotechnology and other applications of knowledge of cell biology. The book will be very useful for beginners to gain insight into their new area, as well as experts to find new facts and expanding horizons.
The book begins with the chapter "Tight Junctions" by Lorenza González-Mariscal, Miguel Quirós, Mónica Díaz-Coránguez and Pablo Bautista. It can be found the symbolism of it, because it talks about the key structures in the epithelial tissue, which boundaries the external and internal spaces. This chapter is an excellent review of biological functions of this type of cell-cell adhesion mechanisms, as well as their complex molecular organization. With abundance of illustrations which are clear, beautifully colored and well fit within the text, chapter is a very good source of information on the topic entitled. Pathobiological aspect will also be very attractive for clinically oriented experts.
From the chapter 2nd the reader goes down under the surface of the cell and there can be firstly encounter with the intracellular structures that are newly described and therefore probably still not enough known to the general scientific community.
Chapter 2nd "Tubulohelical Membrane Arrays, annulate Lamellae and Nuclear Pores: Tripartite Membrane Architecture with the Participation of Nucleoporins" by authors Siegfried and Elena Kiseleva Reipert gives an overview of structure and function of intracellular structures with nucleoporins: nuclear pore complex (NPC), annulate lamellae pore complex (ALPC) and tubulohelical membrane array (TUHMA). Most of the chapter is devoted to TUHMA which is a novel organelle-like membrane specialization that was observed for the first time in the kidney epithelial cell line PtK2 by Reipert et al. (2009). This review and original results also raises many fundamental questions related to the interactions of proteins and membranes, self assembly of complex structures, the spatial organization of membranes and proteins, and cell architecture in general. Perfectly prepared, technically very clear and apparent original images from EM and fluorescence make this chapter even more remarkable.
In the third chapter, in the interior of the cell we have encountered with the most abundant protein of the eukaryotic cell, actin. Although its first described function is in muscle contraction, it is certain that its ubiquitous nature and abundance is associated with its participation in many extremely important cellular processes such as cell motility, cytokinesis, movement of organelles and vesicles, establishment of cell shape and cell junctions. Authors of chapter 3rd Olga I. Povarova, Anna I. Sulatskaya, Irina M. Kuznetsova and Konstantin K. Turov focused their chapter called "Actin Folding, Structure and Function: Is It a Globular or an Intrinsically disordered protein?" primarily "on the processes of actin folding and unfolding and on the validation of the hypothesis that G-actin belongs to the so-called "intrinsically disordered" (ID) proteins."
The other component of the cytoskeleton, microtubules, have been reviewed in chapter 4th. Although microtubules are widespread structures in eukaryotic type of the cell, in animals, plants and fungi, there are specificities in chemical structure of protein tubulin and ways of organizing microtubules in plants. In the chapter called „Microtubules During the Cell Cycle of Higher Plant Cells“ author Elena Smirnova gived „an overview of basic and mainly structural aspects of plant microtubule cytoskeleton“ and „draw attention to unsolved problems“. This chapter is a very broad story about the molecular interactions, dynamics, microtubule nucleation, microtubule associated proteins (MAPs) and plant motors. Complex organization of microtubule cytoskeleton in plant cell has been described during interphase and cell division. Thus, the particular parts of the text devoted to the radial and cortical microtubule system in interphase and preprophase band of microtubules (PPB), mitotic spindle and phragmoplast in the cell division. „Among the intriguing questions that remain are: the relationship between cortical microtubules and cellulose microfibrils orientation, the role of the radial microtubules and PPB in morphogenesis of the mitotic spindle, the molecular mechanisms of MTOC-independent plant spindle assembly as compared to other organisms, and even more, if one is enough curios and inquisitive to look inside the plant cell.“
In the section "Genetic Material: Structure and Expression" four chapters are classified. Section begins with "digging" by the hereditary material. In the chapter 5th „Centromere Evolution: Digging into Mammalian Primary Constriction“ by Giuliana Giannuzzi,
Claudia Rita Catacchio and Mario Ventura a detailed overview of centromere evolution in mammals is presented. Characteristics of centromeric function, centromeric DNA  organization and specialized chromatin structure have been studied trough mammal taxon. Comparison of different mammal groups, primates and non-primates, points to the laws of the evolutionary process. An abundance of data in this analysis of chromosomal similarities and differences among species gives the opportunity to understand the general mechanisms of genome evolution.....

Prof. dr Stevo Najman
Medical Faculty, Niš


Section 1 Cell Structures and Functions .

 1 Tight Junctions 3 Lorenza González-Mariscal, Miguel Quirós, Mónica Díaz-Coránguez and Pablo Bautista

 2 Tubulohelical Membrane Arrays, Annulate Lamellae and Nuclear Pores: Tripartite Membrane Architecture with the Participation of Nucleoporins 31 Siegfried Reipert and Elena Kiseleva

 3 Actin Folding, Structure and Function: Is It a Globular or an Intrinsically Disordered Protein? 57 Olga I. Povarova, Anna I. Sulatskaya, Irina M. Kuznetsova and Konstantin K. Turoverov

 4 Microtubules During the Cell Cycle of Higher Plant Cells 81 Elena Smirnova

Section 2 Genetic Material: Structure and Expression .

 5 Centromere Evolution: Digging into Mammalian Primary Constriction 105 Giuliana Giannuzzi, Claudia Rita Catacchio and Mario Ventura

 6 mRNA Biogenesis in the Nucleus and Its Export to the Cytoplasm 131 Naoko Fujiwara, Takuya Shiki and Seiji Masuda

 7 Membrane Initiated Effects of 1α,25-Dihydroxyvitamin D3 in Prostate Cancer Cells: Effects on AP1 and CREB Mediated Transcription 153 Dennis Larsson, Adele Jonas, Niklas Bergsten, Fredrik Ståhl and Sandra Karlsson

 8 Genetic Transformation and Analysis of Protein-Protein Interaction of Class B MADS-Box Genes from Dendrobium moniliforme 163 Supatida Abdullakasim and Takashi Handa

Section 3 Molecular and Cellular Regulatory Mechanisms .

 9 Exploring Secrets of Nuclear Actin Involvement in the Regulation of Gene Transcription and Genome Organization 181 Yong Zhong Xu, Cynthia Kanagaratham and Danuta Radzioch

 10 Signaling of Receptor Tyrosine Kinases in the Nucleus 211 Sally-Anne Stephenson, Inga Mertens-Walker and Adrian Herington

 11 G Protein-Coupled Receptors-Induced Activation of Extracellular Signal-Regulated Protein Kinase (ERK) and Sodium-Proton Exchanger Type 1 (NHE1) 235 Maria N. Garnovskaya

 12 The Kinetochore and Mitosis: Focus on the Regulation and Correction Mechanisms of Chromosome-to-Microtubule Attachments 259 Rita M. Reis and Hassan Bousbaa

 13 Molecular and Sub-Cellular Gametogenic Machinery of Stem and Germline Cells Across Metazoa 279 Andrey I. Shukalyuk and Valeria V. Isaeva

 14 Drosophila: A Model System That Allows in vivo Manipulation and Study of Epithelial Cell Polarity 315 Andrea Leibfried and Yohanns Bellaïche

 15 Development and Cell Polarity of the C. elegans Intestine 335 Olaf Bossinger and Michael Hoffmann

 16 Intercellular Communication 361 Nuri Faruk Aykan

Section 4 Cellular Basis of Disease and Therapy .

 17 Adult Stem Cells in Tissue Homeostasis and Disease 379 Elena Lazzeri, Anna Peired, Lara Ballerini and Laura Lasagni

 18 Claudins in Normal and Lung Cancer State 423 V. Morales-Tlalpan, C. Saldaña, P. García-Solís, H. L. Hernández-Montiel and H. Barajas-Medina

 19 Biology of Cilia and Ciliopathies 423 David Alejandro Silva, Elizabeth Richey and Hongmin Qin

 20 The Roles of ESCRT Proteins in Healthy Cells and in Disease 453 Jasmina Ilievska, Naomi E. Bishop, Sarah J. Annesley and Paul R. Fisher

 21 Autologous Grafts of Mesenchymal Stem Cells – Between Dream and Reality 481 Frédéric Torossian, Aurelie Bisson, Laurent Drouot, Olivier Boyer and Marek Lamacz

Section 5 New Methods in Cell Biology .

 22 Salivary Glands: A Powerful Experimental System to Study Cell Biology in Live Animals by
Intravital Microscopy 503 Monika Sramkova, Natalie Porat-Shliom, Andrius Masedunkas, Timothy Wigand, Panomwat Amornphimoltham and Roberto Weigert

 23 Evaluation of Mitochondrial DNA Dynamics Using Fluorescence Correlation Analysis 525 Yasutomo Nomura

 24 Regeneration and Recycling of Supports for Biological Macromolecules Purification 535 Marcello Tagliavia and Aldo Nicosia .

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Published by: Unknown - Sunday, June 23, 2013


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