Open Access Medical Books



Edited by Alexander A. Vitin .

190 pages .
Open Access .

Success of public health programs and advances in modern medicine have substantially increased longevity and survival of sick patients, suffering from various maladies with increased potential of major complications, such as limb and various tissues gangrene.
Gangrene is the term used to describe the necrosis or death of soft tissue due to obstructed circulation, usually followed by decomposition and putrefaction, a serious, potentially fatal complication, that has been well known to generations of physicians for epochs. Despite the immense experience in this field, gained by medicine during its centuries-long history, and impressive recent advances, management of gangrene still presents a significant clinical problem, which is still far from being completely resolved.
With ever-growing body of evidence in favor of various treatment modalities, no consensus has been reached so far in respect to superior efficiency of any of the suggested methods. Indeed, even today, with the enormous contemporary armamentarium of treatment methods and immediate access to information literally at his fingertips, a physician, while treating various conditions leading to gangrene/necrosis development, oftentimes faces more unanswered questions than enjoys luxury of choice from plenty of ready-to-use solutions with well-proved efficacy.
In the presented book, the attempt has been made to explore the most important aspects of such detrimental conditions, as are gangrene and necrosis. These included etiology, predisposing factors, demography, pathologic anatomy and mechanisms of development, molecular biology, immunology, microbiology and more. A variety of management strategies, including pharmacological treatment options, surgical and non-surgical solutions and auxiliary methods, are also extensively discussed in the book's chapters. The main goal of this book is not only to provide an easy access to the up-to-date information on the selected topics, but also to help reader to obtain a clear, objective, bias-free and comprehensive picture of the problem.
The presented book lays no claim of encompassing the whole of the problem in all its complexity. Such endeavor would likely have required a multi-volume manuscript.
Rather, the book offers a collection of carefully selected reports of original studies, case presentations and comprehensive review articles, contributed by physicians, who have conducted an extended research in the selected area, experts, who possess a vast, sometimes exquisite experience in practical management of gangrene and necrosis of different locations. The fact that contributors present a variety of clinical disciplines and work in different countries certainly multiplies values of their shared opinions and unique experience.
The presented book contains no unanimously approved recipes and offers no guidelines for immediate implementation. More importantly, the book provides an arena for expert opinions exchange and experience sharing, the approach we believe to be mostly productive, and which we have been following through, while trying to accomplish a task of this book composing and editing.
First part of the book discusses Fournier's gangrene, by far most lethal condition within a spectrum of all maladies complicated by gangrene-necrosis development.
This part contains five chapters, discussing in details pathogenesis, diagnosis and natural course of FG, and also treatment options, prognosis and outcome.
Second part, that includes three chapters, is dedicated to the management of intestinal ischemia and bowel necrosis, still difficult-to-diagnose and treat conditions with very high mortality.
Third part contains three chapters, discussing different aspects of diabetic foot gangrene, lung necrosis and also human immunodeficiency-related gangrene.
Fourth part includes two chapters, discussing various aspects of gangrene management, such as antibiotic treatment and hyperbaric oxygen therapy.
I would like to extend my special thanks to all contributors for their outstanding work in putting together a group of such compelling articles, and also for responding to entreaties for revisions and updates with admirable patience and promptness. In particular, I would like to express my deepest appreciation and personal gratitude to Ms. Viktorija Zgela, without whose devotion, tireless, incessantly intense work, continuous help, support and valuable advise this book, most certainly, would never make its way to readers.
We hope that this book will help readers in expanding their knowledge and provide some new ideas for further improvement of care of the patients suffering from conditions, involving gangrene and tissue necrosis, which constitute the very purpose of this collective work.

Alexander A. Vitin, MD, Ph.D.
University of Washington


Part 1 of the Textbook : Fournier’s Gangrene: Current Concepts and Treatment Options .

 1 Gangrene: The Prognostic Factors and Validation of Severity Index in Fournier’s Gangrene 3 Ik Yong Kim

 2 Fournier’s Gangrene: Diagnostic and Therapeutic Considerations 19 David Kearney

 3 Perineal Gangrene: Clinical and Therapeutic Features and Pronostic Analysis of 35 Cases 29 Slim Jarboui, Ayoub Zoghlami and Dorsaf Othmani

 4 Fournier’s Gangrene 37 Ndubuisi Eke and John E. Raphael

 5 Fournier’s Gangrene – Medical and Surgical Considerations 49 Oscar Estrada Ferrer

Part 2 of the Textbook : Intestinal Ischemia and Bowel Gangrene .

 6 Intestinal Ischemia and Gangrene 69 Vivek Srivastava, Vaibhav Pandey and Somprakas Basu

 7 Segmental Small-Bowel Gangrene Associated with Yersinia pseudotuberculosis Infection 85 H Seddik, A El Khattabi, A Abouzahir, O El Mansari, H En-Nouali and M Rabhi

 8 Gangrene of Large Bowel Due to Volvulus-Etiopathogenesis, Management and Outcome 91 Norman Oneil Machado

Part 3 of the Textbook : Diabetic Foot, Gangrenous Lung Disease and HIV-Induced Gangrene .

 9 Gangrene Associated with Human Immunodeficiency Virus (HIV) 105 Malladi VSS, Abkari S and Srinivasan VR

 10 Gangrenous Lung Disease 113 Chih-Hao Chen

 11 Diabetic Foot and Gangrene 121 Jude Rodrigues and Nivedita Mitta

Part 4 of the Textbook : Necrosis and Gangrene: Current Management Options .

 12 Effect of Macrolide Antibiotics on Biological Activities Induced by Clostridium perfringens Alpha-Toxin 147 Jun Sakurai and Masataka Oda

 13 Hyperbaric Oxygen Therapy in the Treatment of Necrosis and Gangrene 165 Alexander A. Vitin .

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Published by: Unknown - Friday, June 7, 2013


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