Open Access Medical Books



Edited by Jagat R. Kanwar .

532 pages .
Open Access .
ISBN 978-953-51-0592-3 .

Immunology is a branch of biomedical sciences covering the broad concepts of immune system and its components of all the living beings. It is a study of the immune system physiology both in healthy and diseased states. In general, the immune system safeguards the human body from several infections and also evades the generation of cancerous cells and their attack. However, a hairline margin determines the actual mechanism of body defence termed as immunity and as autoimmunity characterised by the loss of tolerance. An imbalance in the immune cell regulation leads to the generation of several of the autoimmune diseases ranging from organ specific type to the systemic ones which also includes cancer. Though the precise pathogenic mechanisms behind the autoimmunity aren’t yet identified, previous studies identified the genetic inheritance, infections and environmental pollutants as the major risk factors associated with the disease. The principle motto of this book is to serve the students, scholars and research personnel with up to date literature from the basics of immunology to the cutting edge techniques employed to counteract the diseased states. Added to the ease of access, peer review and open access will be one click away from the readers to have a complete understanding of the topic of their interest. I strongly hope that a majority of them will be benefitted from the books and find useful for applications into clinical research.
The first chapter by Dr. Butsch Kovacic Melinda covers the details of immune cell pathology involved in cervical cancer and its diagnostic importance, vaccines for therapy providing insights on the clinical studies conducted and evaluated. This will surely highlight the understanding of the disease and gap that needs to be filled.
Computational studies lead to the development of a mathematical model that unmasked the secrets behind the adaptive immune system functioning and also for determining the optimum immunization. This chapter provided by Dr. De Castro Alexandre is interesting in explaining the simulations that found the dynamic behaviour and the antigen dependency for B‐cell memory. It is followed by the review by Dr. Orozco‐Suarez Sandra who explained the details of immune mediated CNS diseases along with therapeutic approaches for epilepsy. Plasma Exchange has attracted attention as new therapeutic intervention for the autoimmune neuromyelitis optica. The details of its pathology and treatment procedures are explained by Dr Bonnan Mickael. The novel findings of Pattern recognition receptors and their role in the cancer aetiopathogenesis is discussed in chapter by Dr. Kutikhin Anton substantiating the concepts of immunology and its importance for future therapeutics.
Dr. Kuricova Miroslava dealt the aspects of Environmental xenobiotics and immunotoxicity as a separate chapter including the concepts of developing in vitro models for toxicity evaluation. The next chapter by Dr. Garcia‐Munoz Ricardo, is about Chronic Lymphocytic Leukemia, a unique B‐cell malignancy updates our current understanding with inclusions on its pathogenesis and immune dysregulation.
The conceptual literature on neuroimmune regulators in brain disorders is covered by Dr. Neal James and the age related immune responses and alterations by Dr. Goriely Stanislas. Next chapters by Dr. Maier Olaf deal the interesting aspects of oligodendrocyte differentiation, its regulation and remyelination is followed by the explanations of Prof. Hahm Bumsuk on mechanistic viral ploy for escape from host immunity and its understanding for developing immunotherapeutic applications.
Valuable information on early nutrition and its impact on immunity, mother and foetus immunological interactions are summarised as a separate chapter by Prof. Boehm Günther. Prof. Cooper Edwin took efforts and provided exclusive information for comparing the adaptive immunity in prokaryotes and eukaryotes and the interesting outcomes will surely attract the readers in his chapter. Valuable additions are made by Dr. Robinson‐Agramonte Maria on the detailed pathology of glial cells and axons in multiple sclerosis, its treatment and Dr. Sattler Susanne covered valuable information on the immunobiology of regulatory B‐cells and their impact on the autoimmune and allergic disorders in her chapter. Chapter’s by Prof. Mehrzad Jalil & Dr. Owais Mohammad will conclude covering the enthusiastic concepts of neutrophils, their interactions with pathogens along with the addressing of cutting edge techniques and the detailed biology of Toll‐like receptor, its implications in various diseased states and its future therapeutic modulation. In chapter by Prof Kanwar covered the study of TH17 cells in cancer and inflammation. This field has been one of the fast‐moving and exciting subject areas in immunology of immune‐mediated chronic inflammatory diseases and autoimmunity, where the pathogenic role of TH17 cells has been well documented. Based on the evidence provided in this chapter from both human and clinical studies data, TH17 cells and TH17‐associated cytokines/effector molecules have been shown to have both pro‐tumorigenic and anti‐tumorigenic functions. Lastly, chapter by Prof Sehgal and Prof Kanwar covered the immunology of leishmaniasis and its future prospective for the development of vaccines to leishmaniasis. Recent investigations have provided new insight into the role of cells of the innate immunity.
Identification of new antigen candidates with broad species coverage, and a greater understanding of the immunology of protective immunity to leishmaniasis open new strategies in clinical vaccine to leishmaniasis.

Dr. Jagat R. Kanwar
Deakin University,


Section 1 of the Textbook : Immunology of Viruses and Cancer .

 1 Cytokines and Markers of Immune Response to HPV Infection 3 Jill Koshiol and Melinda Butsch Kovacic

 2 Viruses Strive to Suppress Host Immune Responses and Prolong Persistence 23 Curtis J. Pritzl, Young-Jin Seo and Bumsuk Hahm

 3 TH17 Cells in Cancer Related Inflammation 43 Rupinder K. Kanwar and Jagat R. Kanwar

 4 Is Chronic Lymphocytic Leukemia a Mistake of Tolerance Mechanisms? 61 Ricardo García-Muñoz, Judit Anton-Remirez, Jesus Feliu, María Pilar Rabasa, Carlos Panizo and Luis Llorente

 5 Pattern Recognition Receptors and Cancer: Is There Any Role of Inherited Variation? 83 Anton G. Kutikhin

Section 2 of the Textbook : Basics of Autoimmunity and Multiple Sclerosis .

 6 Glial and Axonal Pathology in Multiple Sclerosis 103 Maria de los Angeles Robinson-Agramonte, Alina González-Quevedo and Carlos Alberto Goncalves

 7 Adaptive Immune Response in Epilepsy 135 Sandra Orozco-Suárez, Iris Feria-Romero, Dario Rayo, Jaime Diegopérez, Ma.Ines Fraire, Justina Sosa, Lourdes Arriaga, Mario Alonso Vanegas, Luisa Rocha, Pietro Fagiolino and Israel Grijalva

 8 Plasma Exchange in Severe Attacks Associated with Neuromyelitis Optica Spectrum Disorder 159 Bonnan Mickael and Cabre Philippe

 9 Regulatory B Cells - Implications in Autoimmune and Allergic Disorders 177 Susanne Sattler, Luciën E.P.M. van der Vlugt, Leonie Hussaarts, Hermelijn H. Smits and Fang-Ping Huang

 10 The CNS Innate Immune System and the Emerging Roles of the Neuroimmune Regulators (NIRegs) in Response to Infection, Neoplasia and Neurodegeneration 201 J. W. Neal, M. Denizot, J. J. Hoarau and P. Gasque

 11 Regulation of Oligodendrocyte Differentiation: Relevance for Remyelination 241 Olaf Maier

Section 3 of the Textbook : Nutrition and Immunology .

 12 Innate Immune Responses in the Geriatric Population 269 Nathalie Compté and Stanislas Goriely

 13 Development of the Immune System - Early Nutrition and Consequences for Later Life 315 JoAnn Kerperien, Bastiaan Schouten, Günther Boehm, Linette E.M. Willemsen, Johan Garssen, Léon M.J. Knippels and Belinda van’t Land

 14 Immune System and Environmental Xenobiotics - The Effect of Selected Mineral Fibers and Particles on the Immune Response 335 Miroslava Kuricova, Jana Tulinska, Aurelia Liskova, Mira Horvathova, Silvia Ilavska, Zuzana Kovacikova, Elizabeth Tatrai, Marta Hurbankova, Silvia Cerna, Eva Jahnova, Eva Neubauerova, Ladislava Wsolova, Sona Wimmerova, Laurence Fuortes, Soterios A. Kyrtopoulos and Maria Dusinska

Section 4 of the Textbook : Basic of Immunology and Parasite Immunology .

 15 Molecular Aspects of Neutrophils as Pivotal Circulating Cellular Innate Immune Systems to Protect Mammary Gland from Pathogens 383 Jalil Mehrzad

 16 An Ag-Dependent Approach Based on Adaptive Mechanisms for Investigating the Regulation of the Memory B Cell Reservoir 423 Alexandre de Castro

 17 Toll Like Receptors in Dual Role: Good Cop and Bad Cop 445 Saba Tufail, Ravikant Rajpoot and Mohammad Owais

 18 Immunology of Leishmaniasis and Future Prospective of Vaccines 479 Rakesh Sehgal, Kapil Goyal, Rupinder Kanwar, Alka Sehgal and Jagat R. Kanwar

 19 Adaptive Immunity from Prokaryotes to Eukaryotes: Broader Inclusions Due to Less Exclusivity? 495 Edwin L. Cooper .

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Published by: Unknown - Friday, June 14, 2013


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