Open Access Medical Books



Edited by Andrew B. Lemmey .

314 pages .
Open Access .

Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory arthritis, which features destruction of synovial joints, systemic inflammation, functional disability, reduced quality of life, and increased morbidity and mortality. It is relatively common, having a world-wide prevalence of between 0.5-2%, and is associated with huge social and economic costs. Consequently, it is the most important of the inflammatory arthritides.
The aim of Rheumatoid Arthritis – Etiology, Consequences and Co-Morbidities is not to provide a comprehensive commentary on RA (several of these are already in publication), but rather to provide interesting, thought-provoking, and up-to-date perspectives on a variety of aspects of current research into this condition. In taking this approach, Rheumatoid Arthritis – Etiology, Consequences and Co-Morbidities includes topics not usually covered by conventional publications. As such, it is an ideal reference and source of inspiration and direction for investigators, whatever their level, in the challenging and exciting field of rheumatology research.
This book is broadly divided into: “Etiology” (chapters 1-10), and “Consequences and Co-Morbidities” (chapters 11-16).
The editor would like to thank the chapter authors for their excellent contributions, and extend to them the wish that their current and future research endeavors are fruitful. Special thanks are also given to Anja Filipovic and other InTech staff for their expert editorial assistance in publishing this book.
RA is an exciting condition to investigate. Hopefully, this book will help to advance research into the mechanisms and treatment of the disease.

Dr. Andrew B. Lemmey
School of Sport, Health & Exercise Sciences,
College of Health & Behavioral Sciences,
Bangor University,


Part 1 of the Textbook : Rheumatoid Arthritis - Etiology .

 1 Cytokine Profile of T Cells in the Joints of Rheumatoid Arthritis and Its Murine Models 3 Takashi Usui

 2 Invariant Natural Killer T Cells in Rheumatoid Arthritis and Other Inflammatory Arthritides 19 Evin Sowden and Wan-Fai Ng

 3 IL-12 Family Cytokines in Inflammation and Bone Erosion of Rheumatoid Arthritis 41 Ran Wei, Alastair J. Sloan and Xiao-Qing Wei

 4 The Role of Neutrophils in Rheumatoid Arthritis – Experiments In Vitro: A Change of Conception? 59 Michal Gajewski, Przemyslaw Rzodkiewicz and Slawomir Maslinski

 5 Molecular Mechanisms of Rheumatoid Arthritis Revealed by Categorizing Subtypes of Fibroblast-Like Synoviocytes 73 Katsuhiko Ishihara and Hideya Igarashi

 6 Lysosomal Glycosidases in Degradation of Human Articular Cartilage 97 Janusz Popko, Tomasz Guszczyn, Sławomir Olszewski, Krzysztof Zwierz

 7 Innate Mechanisms of Synovitis – Fibrin Deposits Contribute to Invasion 111 Olga Sánchez-Pernaute, Antonio Gabucio, Astrid Jüngel, Michel Neidhart, María Comazzi, Gabriel Herrero-Beaumont, Renate E. Gay and Steffen Gay

 8 Glycoproteomics of Lubricin-Implication of Important Biological Glyco- and Peptide-Epitopes in Synovial Fluid 131 Liaqat Ali, Chunsheng Jin and Niclas G. Karlsson

 9 Profiling Inflammatory Genes and Signaling Pathways in Rheumatoid Synoviocytes for RA Light Therapy 153 Yasuko Shibata and Yoshimitsu Abiko

 10 The Role of miRNA in Rheumatoid Arthritis 171 Seiji Kawano and Yuji Nakamachi

Part 2 of the Textbook : Consequences and Co-Morbidities .

 11 Rheumatoid Arthritis: A Historical and Biopsychosocial Perspective 189 Yulia Zyrianova

 12 Sexual Health and Intimate Relationships in Rheumatoid Arthritis 215 Kristina Areskoug Josefsson and Ulrika Öberg

 13 Association of Cardiovascular Disease with the Metabolic Syndrome in a Predominantly Male Cohort with Rheumatoid Arthritis 235 G.S. Kerr, I. Sabahi, J.S. Richards, T.R. Mikuls, B.V. Rangan, A. Reimold, G.W. Cannon, D. Johnson and L. Caplan

 14 Nontuberculous Mycobacterium Infections in Rheumatoid Arthritis Patients 245 Maiko Watanabe and Shogo Banno

 15 Increased Mortality Rate in Rheumatoid Arthritis Patients with Neurological Symptoms or Signs Secondary to Cervical Spine Subluxations – Reduced Mortality if Postoperative Ankylosis is Achieved 265 Albert C. Paus, Harald Steen, Petter Mowinckel, Jo Røislien and Jens Teigland

 16 Surgical Considerations of Rheumatoid Disease Involving the Craniocervical Junction and Atlantoaxial Vertebrae 275 T.M. Murphy, L. McEvoy and C. Bolger

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Published by: Unknown - Wednesday, June 12, 2013


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