Open Access Medical Books



Edited by Alena Bulikova .

242 pages .
Open Access .

Immunity seems to be a fascinating system in the human body, whose role has never been understood in detail, despite the great progress in our knowledge about its role, regulation and its disorders. The same goes for autoimmunity diseases as well as antiphospholipid antibodies presence and antiphospholipid syndrome.
Due to humoral nature of these autoantibodies they can impact every tissue and due to their heterogeneity and complex actions they can be connected with wide spectrum of clinical manifestations. This leads to the fact that almost every medical doctor, regardless of his or her specialty, can come across a patient affected by some of these manifestations. This is why it is necessary to share the knowledge possessed by experts in this subject with the aim to help patients with antiphospholipid antibodies presence. Finally, this is why this book is presented to a wide range of readers. Forty seven contributors from nine countries bring together their knowledge and also their own experience from different fields of their professional work with the aim of
providing a valuable resource for improving some of the points of view, decisions and treatment success in the antiphospholipid antibodies positive patients’ management.
May the authors' hopeful expectations fulfil.
May the readers find the answers for their questions.
May the patients with antiphospholipid syndrome meet the doctor who has read this book that had changed his/her knowledge.
Best regards.

Alena Buliková, M.D., Ph.D.
University Hospital Brno
Czech Republic


Section 1  Antiphospholipid Syndrome: Changing Knowledge During the Time – The ”Four P” Pattern .

Section 2 Pathophysiologic Mechanisms Involved in Antiphospholipid Antibodies Action .

 1 2-Glycoprotein I – A Protein in Search of Function 13 Anthony Prakasam and Perumal Thiagarajan

 2 Structural Changes in 2-Glycoprotein I and the Antiphospholipid Syndrome 23 Çetin Ağar, Philip G. De Groot and Joost C.M. Meijers

 3 Genetics of Antiphospholipid Syndrome 35 Jesús Castro-Marrero, Eva Balada, Josep Ordi-Ros and Miquel Vilardell-Tarrés

Section 3 Antiphospholipid Antibodies Detection, Clinical Manifestation and Treatment .

 4 Antiphospholipid Antibodies – Detection and Clinical Importance 69 Jakub Swadzba and Jolanta Kolodziejczyk

 5 Presence of Antibodies Against Mycoplasma penetrans in Patients with Antiphospholipid Syndrome 85 Elizabeth Herrera-Saldivar, Antonio Yáñez, David Bañuelos, Constantino Gil and Lilia Cedillo

 6 Antiphospholipid Antibodies and Their Association with Atherosclerotic Changes in Patients with Systemic Lupus Erythematosus – Review of Literature and Own Experiences 97 Katarzyna Fischer, Jacek Fliciński and Marek Brzosko

 7 The Kidney in Antiphospholipid Syndrome 125 Alexandru Caraba, Viorica Crişan, Andreea Munteanu, Corina Şerban, Diana Nicoară and Ioan Romoşan

 8 The Management of Antiphospholipid Antibodies Affected Pregnancy 139 Kenji Tanimura, Yashuhiko Ebina, Yoko Maesawa, Ryoichi Hazama and Hideto Yamada

 9 Antiphospholipid Autoantibodies in Women with Recurrent Gestational Failures – Controversies in Management 151 Áurea García Segovia, Margarita Rodríguez-Mahou, Pedro Caballero and Silvia Sánchez-Ramón

 10 Antiphospholipid Syndrome in Pregnancy 161 Kjell Haram, Eva-Marie Jacobsen and Per Morten Sandset

 11 Update on Antiphospholipid Antibody Syndrome Management 175 Rocco Manganelli, Salvatore Iannaccone, Serena Manganelli and Mario Iannaccone

Section 4 Conclusion .

 12 Antiphospholipid Syndrome – An Evolving Story of a Multisystemic Disease 199 Silvia S. Pierangeli, Rohan Willis, Brock Harper and E. Nigel Harris

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Published by: Unknown - Saturday, June 8, 2013


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