Open Access Medical Books


Edited by Deniz Ekinci .
Open Access .
462 pages .
ISBN 978-953-51-0076-8 .

Biochemistry includes the chemical processes in living systems which govern all living organisms and living processes. It deals with the structures and functions of biomolecules. Over the recent years, biochemistry has become responsible for explaining living processes such that many scientists in the life sciences from agronomy to medicine are engaged in biochemical research. The main focus of biochemistry is in understanding how biomolecules give rise to the chemical processes that occur within living cells. Although extensive research has been performed on biochemistry for many years, there is still deep need of understanding the biochemical reactions as well as the structures of biomolecules.
This book titled “Biochemistry” contains a selection of chapters focused on the research area of proteins, enzymes, cellular mechanisms and chemical compounds used in relevant approaches. The book provides an overview on basic issues and some of the recent developments in biochemical science and technology. Particular emphasis is devoted to both theoretical and experimental aspect of modern biochemistry. The primary target audience for the book includes students, researchers, biologists, chemists, chemical engineers and professionals who are interested in biochemistry, molecular biology and associated areas.
The textbook is written by international scientists with expertise in protein biochemistry, enzymology, molecular biology and genetics many of which are active in biochemical and biomedical research. I would like to acknowledge the authors for their contribution to the book. We hope that the textbook will enhance the knowledge of scientists in the complexities of some biochemical approaches; it will stimulate both professionals and students to dedicate part of their future research in understanding relevant mechanisms and applications.

Dr. Deniz Ekinci
Assistant Professor of Biochemistry
Ondokuz Mayıs University


Part 1 Proteins and hormones .

 1 Protein Flexibility and Coiled-Coil Propensity: New Insights Into Type III and Other Bacterial Secretion Systems 3 Spyridoula N. Charova, Anastasia D. Gazi, Marianna Kotzabasaki, Panagiotis F. Sarris, Vassiliki E. Fadouloglou, Nickolas J. Panopoulos and Michael Kokkinidis

 2 Peptides and Peptidomimetics as Tools to Probe Protein-Protein Interactions – Disruption of HIV-1 gp41 Fusion Core and Fusion Inhibitor Design 39 Lifeng Cai, Weiguo Shi and Keliang Liu

 3 Profilin, and Vascular Diseases 65 Mohammad T. Elnakish and Hamdy H. Hassanain

 4 E. coli Alpha Hemolysin and Properties 107 Bakás Laura, Maté Sabina, Vazquez Romina and Herlax Vanesa

 5 Human ERα and ERβ Splice Variants: Understanding Their Domain Structure in Relation to Their Biological Roles in Breast Cancer Cell Proliferation 141 Ana M. Sotoca, Jacques Vervoort, Ivonne M.C.M. Rietjens and Jan-Åke Gustafsson

 6 GPCRs and G Protein Activation 161 Waelbroeck Magali

 7 Application of Quantitative Immunogold Electron Microscopy to Determine the Distribution and Relative Expression of Homo- and Heteromeric Purinergic Adenosine A1 and P2Y Receptors 189 Kazunori Namba

Part 2 Enzymes .

 8 Carbonic Anhydrase and Heavy Metals 205 Maria Giulia Lionetto, Roberto Caricato, Maria Elena Giordano, Elisa Erroi and Trifone Schettino

 9 Enzymology of Bacterial Lysine Biosynthesis 225 Con Dogovski, Sarah. C. Atkinson, Sudhir R. Dommaraju, Matthew Downton, Lilian Hor, Stephen Moore, Jason J. Paxman, Martin G. Peverelli, Theresa W. Qiu, Matthias Reumann, Tanzeela Siddiqui, Nicole L. Taylor, John Wagner, Jacinta M. Wubben and Matthew A. Perugini

 10 Enzyme-Mediated Preparation of Flavonoid Esters and Their Applications 263 Jana Viskupicova, Miroslav Ondrejovic and Tibor Maliar

Part 3 Metabolism and Mechanism .

 11 Glucose Metabolism and Cancer 289 Lei Zheng, Jiangtao Li and Yan Luo

 12 HIV-1 Selectively Integrates Into Host DNA In Vitro 305 Tatsuaki Tsuruyama

 13 Distinct Role for ARNT/HIF-1β in Pancreatic Beta-Cell Function, Insulin Secretion and Type 2 Diabetes 321 Renjitha Pillai and Jamie W. Joseph

 14 Modulation of EAAC1-Mediated Glutamate Uptake by Addicsin 341 Mitsushi J. Ikemoto and Taku Arano

 15 Functional Genomics of Anoxygenic Green Bacteria Chloroflexi Species and Evolution of Photosynthesis 365 Kuo-Hsiang Tang

 16 Mechanism of Cargo Recognition During Selective Autophagy 381 Yasunori Watanabe and Nobuo N. Noda

Part 4 Regulatory Molecules .

 17 Role of Ceramide 1-Phosphate in the Regulation of Cell Survival and Inflammation 399 Alberto Ouro, Lide Arana, Patricia Gangoiti and Antonio Gomez-Muñoz

 18 Cholesterol: Biosynthesis, Functional Diversity, Homeostasis and Regulation by Natural Products 419 J. Thomas, T.P. Shentu and Dev K. Singh

 19 Stobadine – An Indole Type Alternative to the Phenolic Antioxidant Reference Trolox 443 Ivo Juranek, Lucia Rackova and Milan Stefek .

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