Open Access Medical Books



Edited by Supriya Srivastava .

464 pages .
Open Access .
ISBN 978-953-307-987-5 .

Intraepithelial neoplasias (IEN) are preinvasive lesions which are confined to the basement membrane. In developing countries worldwide, where the costs of modern sophisticated healthcare are a problem and issues of cost constraints are becoming widespread, the importance of early and timely diagnosis has become an imperative.
Needless to say, accurate and thorough, macroscopic and histologic examination remains the gold standard, and every other method has to be assessed accordingly. To aid the clinicians and the pathologists, the esteemed and eminent panel of authors are pleased to bring to you a book which is relevant not only to the clinicians to understand and identify preinvasive lesions but also to the researchers and medical students. There is a vast sea of knowledge available in molecular genetic data, concerning a wide variety of IEN, and much of these data, at least where applicable, have been incorporated in this book. The extent to which this information directly influences patients is variable and is dependent on both the type of intraepithelial lesion and the resources available.
Through each chapter, this book discusses in detail the aetiology, pathogenesis, molecular and genetic profile, diagnosis and possible treatments of IEN of an organ. The organs discussed in this book include the oral cavity, the eye and the ocular adnexa, breast, prostate, uterus, cervix and vulva. Each chapter is illustrated with colored images of the preinvasive lesions of that particular organ. Differential diagnosis has been provided wherever required. All of the chapters contain a considerable amount of new information, with latest references and technical advances. This book has been extensively reviewed to take account of the latest developments and the standard WHO system of classification has also been included.
I am deeply obliged to the contributors for their hard work and enthusiasm in supplying such excellent material for the purpose of this book. I would also like to express my gratitude to the publishers for offering me to be a part of this book. I am grateful to Ms Sasa Leporic and the technical staff for their invaluable effort and support provided in the preparation of this book. Lastly, I would like to thank my spouse, Dr Sudeep Saxena and my family, for being a supporting pillar throughout this period.

Supriya Srivastava
Cancer Science Institute, 
National University Of Singapore


Part 1 Intraepithelial Neoplasia of Oral Cavity .

 1 Novel Markers for Diagnosis and Prognosis of Oral Intraepithelial Neoplasia 3 Angela Celetti, Francesco Merolla, Chiara Luise, Maria Siano and Stefania Staibano

Part 2 Intraepithelial Neoplasia of Eye and Ocular Adnexa .

 2 Ocular Surface Squamous Neoplasia 35 Napaporn Tananuvat and Nirush Lertprasertsuke

 3 Excess Fibroblast Growth Factor-7 (FGF-7) Activates β-Catenin and Leads to Ocular Surface Squamous Neoplasia in Mice 63 Chia-Yang Liu and Winston W.-Y. Kao

 4 Conjunctival Intraepithelial Neoplasia – Clinical Presentation, Diagnosis and Treatment Possibilities 79 Valentín Huerva and Francisco J. Ascaso

Part 3 Intraepithelial Neoplasia of Breast .

 5 Intraepithelial Neoplasia of Breast 105 Simonetta Monti and Andres Del Castillo

Part 4 Intraepithelial Neoplasia of Prostate .

 6 Prostate Cancer Precursor Diseases 135 A.G. Papatsoris, C. Kostopoulos, V. Migdalis and M. Chrisofos

 7 Diagnosis of Prostatic Intraepithelial Neoplasia in Luminal Cells Using Raman Spectroscopy 163 Suneetha Devpura, Jagdish Thakur, Seema Sethi, Vaman M. Naik, Fazlul Sarkar, Wael Sakr and Ratna Naik

 8 Chemopreventive Target for Prostate Cancer: Prostatic Intraepithelial Neoplasia 179 J. Arunakaran, S. Banudevi and A. Arunkumar

Part 5 Intraepithelial Neoplasia of Uterus .

 9 Endometrial Intraepithelial Neoplasia 205 Nisreen Abushahin, Shuje Pang, Jie Li, Oluwole Fadare and Wenxin Zheng

Part 6 Intraepithelial Neoplasia of Cervix .

 10 Cervical Intraepithelial Neoplasia – Clinical and Etiological Aspects 243 Raghad Samir and Dan Hellberg

 11 P16INK4A and MIB-1 Expression in Preneoplasia and Neoplasia of Cervix 259 Supriya Srivastava

 12 Cervical Intraepithelial Neoplasia (CIN) (Squamous Dysplasia) 279 Oguntayo Olanrewaju Adekunle

 13 AKNA as Genetic Risk Factor for Cervical Intraepithelial Neoplasia and Cervical Cancer 311 Kirvis Torres-Poveda, Ana I. Burguete-García, Margarita Bahena-Román, Alfredo Lagunas-Martínez and Vicente Madrid-Marina

 14 Cervical Glandular Intraepithelial Neoplasia (CGIN) 337 Narges Izadi-Mood, Soheila Sarmadi and Kambiz Sotoudeh

 15 The Role of the Pap Smear Diagnosis: Atypical Glandular Cells (AGC) 365 Chiung-Ru Lai, Chih-Yi Hsu and Anna Fen-Yau Li

 16 Cytology of Cervical Intraepithelial Glandular Lesions 381 Ana Ovanin-Rakić

Part 7 Intraepithelial Neoplasia of Vulva .

 17 Expression of Vascular Endothelial Growth Factors VEGF- C and D, VEGFR-3, and Comparison of Lymphatic Vessels Density Labeled with D2-40 Antibodies as a Prognostic Factors in Vulvar Intraepithelial Neoplasia (VIN) and Invasive Vulvar Cancer 423 Robert Jach, Grzegorz Dyduch, Małgorzata Radoń-Pokracka, Paulina Przybylska, Marcin Mika, Klaudia Stangel-Wojcikiewicz, Joanna Dulińska-Litewka, Krzysztof Zając, Hubert Huras, Joanna Streb and Olivia Dziadek

 18 Current Insight into Specific Cellular Immunity of Women Presenting with HPV16-Related
Vulvar Intra-Epithelial Neoplasia and Their Partners 443 Isabelle Bourgault-Villada .

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Published by: Unknown - Wednesday, June 26, 2013


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