Open Access Medical Books



Edited by Jianfeng Cai and Rongsheng E. Wang .

474 pages .
Open Access .
ISBN 978-953-51-0244-1.

Protein interactions, including interactions between proteins and proteins, nucleic acids, lipids, carbohydrates, are essential to all aspects of biological processes, such as cell growth, differentiation, and apoptosis. Therefore, investigation and modulation of protein interactions are of significance as it not only reveals the mechanism governing cellular activity, but also leads to potential agents for the treatment of various diseases. In recent years, the development of biochemistry knowledge and instrumentation techniques has greatly facilitated the research in protein interactions. To provide some background information on the protein interactions, and also highlight the examples in the study of protein interactions, this book reviews some latest development in protein interactions, including modulation of protein interactions, applications of analytical techniques, and computer-assisted simulations. It aims to inspire the further development of technologies and methodologies in the understanding and regulation of protein interactions.
Although the chapters included in this book are all addressing protein interactions, we try to separate them into two parts according to their objectives. Chapters in part 1 mainly focus on the investigation of some specific protein-protein or protein-nucleic acid interactions, and try to elucidate the mechanism of specific cellular processes. Part 1 provides some insight of why and how to study protein interactions, and illustrates some approaches to modulate protein interactions. The second part is devoted to the development of various methods for the investigation of protein interactions, including computational modeling. Methods used to study protein interactions often evolve rapidly and many innovative methods or approaches are emerging in this field.
The chapters shown in this part would shed light on the further development and application of analytical techniques and computer simulations.
I would like to thank every author because they have devoted their effort and expertise to prepare the outstanding chapters included in this book. I also thank Dr. Rongsheng E. Wang, the co-Editor of this volume, for his tremendous help on the review and editing of the book. Meanwhile, I want to express my deep appreciation to Ms. Marina Jozipovic for her tireless efforts in distributing, organizing, and processing all of the chapters.

Jianfeng Cai
Assistant Professor, Department of Chemistry,
University of South Florida, Tampa, FL


Part 1 Examples of Protein Interactions .

 1 MOZ-TIF2 Fusion Protein Binds to Histone Chaperon Proteins CAF-1A and ASF1B Through Its MOZ Portion 3 Hong Yin, Jonathan Glass and Kerry L. Blanchard

 2 Autophagy-Mediated Defense Response of Mouse Mesenchymal Stromal Cells (MSCs)
to Challenge with Escherichia coli 23 N.V. Gorbunov, B.R. Garrison, M. Zhai, D.P. McDaniel, G.D. Ledney, T.B. Elliott and J.G. Kiang

 3 The Use of Reductive Methylation of Lysine Residues to Study Protein-Protein Interactions in High Molecular Weight Complexes by Solution NMR 45 Youngshim Lee, Sherwin J. Abraham and Vadim Gaponenko

 4 Regulation of Protein-Protein Interactions by the SUMO and Ubiquitin Pathways 53 Yifat Yanku and Amir Orian

 5 Functional Protein Interactions in Steroid Receptor-Chaperone Complexes 71 Thomas Ratajczak, Rudi K. Allan, Carmel Cluning and Bryan K. Ward

 6 The TPR Motif as a Protein Interaction Module – A Discussion of Structure and Function 103 Natalie Zeytuni and Raz Zarivach

 7 The Two DUF642 At5g11420 and At4g32460-Encoded Proteins Interact In Vitro with the AtPME3 Catalytic Domain 119 Esther Zúñiga-Sánchez and Alicia Gamboa-de Buen

 8 Protein-Protein Interactions and Disease 143 Aditya Rao, Gopalakrishnan Bulusu, Rajgopal Srinivasan and Thomas Joseph

 9 AApeptides as a New Class of Peptidomimetics to Regulate Protein-Protein Interactions 155 Youhong Niu, Yaogang Hu, Rongsheng E. Wang, Xiaolong Li, Haifan Wu, Jiandong Chen and Jianfeng Cai

 10 Protein Interactions in S-RNase-Based Gametophytic Self-Incompatibility 171 Thomas L. Sims

 11 Direct Visualization of Single-Molecule DNA-Binding Proteins Along DNA to Understand DNA–Protein Interactions 195 Hiroaki Yokota

 12 Defining the Cellular Interactome of Disease-Linked Proteins in Neurodegeneration 215 Verena Arndt and Ina Vorberg

 13 Biochemical, Structural and Pathophysiological Aspects of Prorenin and (Pro)renin Receptor 243 A.H.M. Nurun Nabi and Fumiaki Suzuki

 14 Cholesterol-Binding Peptides and Phagocytosis 275 Antonina Dunina-Barkovskaya

Part 2 Studying Protein Interactions .

 15 One-by-One Sample Preparation Method for Protein Network Analysis 293 Shun-Ichiro Iemura and Tohru Natsume

 16 Live In-Cell Visualization of Proteins Using Super Resolution Imaging 311 Catherine H. Kaschula, Dirk Lang and M. Iqbal Parker

 17 Approaches to Analyze Protein-Protein Interactions of Membrane Proteins 327 Sabine Hunke and Volker S. Müller

 18 Relating Protein Structure and Function Through a Bijection and Its Implications on Protein Structure Prediction 349 Marco Ambriz-Rivas, Nina Pastor and Gabriel del Rio

 19 Protein-DNA Interactions Studies with Single Tethered Molecule Techniques 369 Guy Nir, Moshe Lindner and Yuval Garini

 20 Characterization of Protein-Protein Interactions via Static and Dynamic Light Scattering 401 Daniel Some and Sophia Kenrick

 21 Site-Directed Spin Labeling and Electron Paramagnetic Resonance (EPR) Spectroscopy: A Versatile Tool to Study Protein-Protein Interactions 427 Johann P. Klare

 22 Modification, Development, Application and Prospects of Tandem Affinity Purification Method 447 Xiaoli Xu, Xueyong Li, Hua Zhang and Lizhe An .

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Published by: Unknown - Saturday, June 22, 2013


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