Open Access Medical Books



Edited by Andrew B. Lemmey .

Open Access ;
376 pages .

Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory arthritis, which features destruction of synovial joints, systemic inflammation, functional disability, reduced quality of life, and increased morbidity and mortality. It is relatively common, having a world-wide prevalence of between 0.5-2%, and is associated with huge social and economic costs. Consequently, it is the most important of the inflammatory arthritides.
The aim of Rheumatoid Arthritis - Treatment is not to provide a comprehensive commentary on RA (several of these are already in publication), but rather to provide interesting, thought-provoking, and up-to-date perspectives on a variety of aspects of current research into this condition. In taking this approach, Rheumatoid Arthritis - Treatment includes topics not usually covered by conventional publications. As such, it is an ideal reference and source of inspiration and direction for investigators, whatever their level, in the challenging and exciting field of rheumatology research.
This book is sectioned into: “DMARDs (Disease Modifying Anti-Rheumatic Drugs) and NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)” (chapters 1-2), “Biologics” (chapters 3-5), “Potential Therapies” (chapters 6-13), and “Exercise and Alternative Therapies” (chapters 14-17).
The editor would like to thank the chapter authors for their excellent contributions, and extend to them the wish that their current and future research endeavors are fruitful. Special thanks are also given to Anja Filipovic and other InTech staff for their expert editorial assistance in publishing this book. RA is an exciting condition to investigate. Hopefully, this book will help to advance research into the mechanisms and treatment of the disease.

Dr. Andrew B. Lemmey
School of Sport, Health & Exercise Sciences
College of Health & Behavioral Sciences
Bangor University


Part 1 of the Textbook : DMARDs (Disease Modifying Anti-Rheumatic Drugs) and NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) .

 1 The Clinical Role of Glucocorticoids in the Management of Rheumatoid Arthritis 3 Hussein Al-Mossawi and John R. Kirwan

 2 Novel Formulation Approaches for Dermal and Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs 25 Alper Okyar, Yıldız Özsoy and Sevgi Güngör

Part 2 of the Textbook : Rheumatoid Arthritis - Biologics .

 3 The Role of Tocilizumab in the Treatment of Rheumatoid Arthritis 51 Yasuhiko Hirabayashi

 4 Mycobacterial Infections Associated with TNF-α Inhibitors 71 Sarah K. Brode and Theodore K. Marras

 5 Expression of Tumor Necrosis Factor-Alpha (TNF-α TNF-α Converting Enzyme and Matrix Metalloproteinase-3 in SAPHO Syndrome Synovium - A Rare Case Accompanied by Acrodermatitis Continua of Hallopeau: A Case Report and Review of Anti-TNF-α Therapy 93 Koichiro Komiya, Nobuki Terada, Yoshikazu Mizoguchi and Harumoto Yamada

Part 3 of the Textbook : Potential Treatments of Rheumatoid Arthritis .

 6 The Development of Targeted Drug Delivery Systems for Rheumatoid Arthritis Treatment 111 Rebecca A. Bader

 7 Proteasome Targeted Therapies in Rheumatoid Arthritis 133 Aisha Siddiqah Ahmed

 8 Enkorten – A Potential Drug for the Treatment of Rheumatoid Arthritis 155 Nedžad Mulabegović, Jasna Kusturica, Maida Todić-Rakanović, Mirjana Mijanović, Fahir Bečić, Asija Začiragić, Selma Škrbo, Lejla Burnazović-Ristić, Aida Kulo and Svjetlana Loga-Zec

 9 Role of Adrenomedullin in Patients with Rheumatoid Arthritis 173 Etsuo Chosa, Hiroaki Hamada and Toshiyuki Ohkura

 10 Targeting the Metabolism and Receptors of Sphingosine-1- Phosphate for the Treatment of Rheumatoid Arthritis 195 Sylvain G. Bourgoin, Chenqi Zhao and Maria J. Fernandes

 11 Targeting DAMP Activation of Toll-Like Receptors: Novel Pathways to Treat Rheumatoid Arthritis? 211 Theresa H. Page and Kim S. Midwood

 12 Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis 233 Katarina Bauerova, Silvester Poništ, Radomir Nosaľ, Maria Stančikova and Jozef Rovensky

 13 Resveratrol: A Candidate Drug for Treating Rheumatoid Arthritis 269 Tomoyuki Nishizaki and Takeshi Kanno

Part 4 of the Textbook : Exercise and Alternative Therapies of Rheumatoid Arthritis .

 14 Resistance Training for Patients with Rheumatoid Arthritis: Effects on Disability, Rheumatoid Cachexia, and Osteoporosis; and Recommendations for Prescription 287 Andrew B. Lemmey

 15 Molecular Effects of Exercise in Rheumatoid Arthritis 311 Daniel J. Leong and Hui B. Sun

 16 Perceptions Relating to Exercise in Rheumatoid Arthritis 331 Rebecca-Jane Law, David Markland, Peter Maddison and Jeanette M. Thom

 17 Complementary and Alternative Medicine in the Treatment of Rheumatoid Arthritis 351 Chenchen Wang

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Published by: Unknown - Sunday, June 9, 2013


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